Phenotypes associated with this allele

• Allele Symbol: Adar⁺
• Allele Name: wild type
• Allele ID: MGI:2439742
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Adar^tm1b(EUCOMM)Wtsi/Adar^+	B6N(Cg)-Adar^tm1b(EUCOMM)Wtsi/J	MGI:5763825
ht2	Adar^tm2Knk/Adar^+	chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5436439
ht3	Adar^tm1.1Knk/Adar^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5436589

Genotype
MGI:5763825

ht1

• Allelic Composition: Adar^{tm1b(EUCOMM)Wtsi}/Adar⁺
• Genetic Background: B6N(Cg)-Adar^{tm1b(EUCOMM)Wtsi}/J
• Cell Lines: EPD0087_1_D11

Data Sources

IMPC Data for Adar

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX

Genotype
MGI:5436439

ht2

• Allelic Composition: Adar^tm2Knk/Adar⁺
• Genetic Background: chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:65981 )

• no live embryos after E14.5

• some 90% chimeric embryos survive to E12.5-E13.5

• embryos normal up to E11.5

hematopoietic system

abnormal embryonic erythropoiesis ( J:65981 )

• more than 90% of circulating erythrocytes remain nucleated

• some circulating erythrocytes undergo mitosis

liver/biliary system

abnormal liver development ( J:65981 )

• "lacy" appearance of livers at E12.5-E13.5

• hematopoietic islands are present

embryo

abnormal embryonic erythropoiesis ( J:65981 )

• more than 90% of circulating erythrocytes remain nucleated

• some circulating erythrocytes undergo mitosis

Genotype
MGI:5436589

ht3

• Allelic Composition: Adar^tm1.1Knk/Adar⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

mortality/aging ( J:87714 )

N • unexpectedly, mice survived normally