All Phenotypes Adar<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Adar^{tm1b(EUCOMM)Wtsi}/Adar⁺	B6N(Cg)-Adar^{tm1b(EUCOMM)Wtsi}/J	MGI:5763825
ht2	Adar^tm2Knk/Adar⁺	chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5436439
ht3	Adar^tm1.1Knk/Adar⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5436589
ht4	Adar^em1Dmsc/Adar⁺	involves: C57BL/6J * DBA/2	MGI:8346390
cx5	Adar^em1Dmsc/Adar⁺ Ifih1^tm1.1Cln/Ifih1^tm1.1Cln	involves: 129X1/SvJ * C57BL/6J * DBA/2	MGI:8346412

Allelic Composition	Adar^{tm1b(EUCOMM)Wtsi}/Adar⁺
Genetic Background	B6N(Cg)-Adar^{tm1b(EUCOMM)Wtsi}/J
Cell Lines	EPD0087_1_D11

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Adar mutation (83 available)

Data Sources

IMPC Data for Adar

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

IMPC - JAX

Allelic Composition	Adar^tm2Knk/Adar⁺
Genetic Background	chimera involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^tm2Knk mutation (0 available); any Adar mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:65981 )

• no live embryos after E14.5

• some 90% chimeric embryos survive to E12.5-E13.5

• embryos normal up to E11.5

hematopoietic system

abnormal embryonic erythropoiesis ( J:65981 )

• more than 90% of circulating erythrocytes remain nucleated

• some circulating erythrocytes undergo mitosis

liver/biliary system

abnormal liver development ( J:65981 )

• "lacy" appearance of livers at E12.5-E13.5

• hematopoietic islands are present

embryo

abnormal embryonic erythropoiesis ( J:65981 )

• more than 90% of circulating erythrocytes remain nucleated

• some circulating erythrocytes undergo mitosis

Allelic Composition	Adar^tm1.1Knk/Adar⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^tm1.1Knk mutation (0 available); any Adar mutation (83 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:87714 )

N	• unexpectedly, mice survived normally

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

microgliosis ( J:379589 )

• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis

brain inflammation ( J:379589 )

• mice exhibit increased expression of IFN stimulated gene (ISG) mRNAs in brain of 6-week-old mice indicative of brain inflammation; ISG expression rapidly increases in young mice and is predominantly in deep brain areas indicating neuroinflammation

nervous system

astrocytosis ( J:379589 )

• GFAP staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased astrocytosis

microgliosis ( J:379589 )

• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis

brain inflammation ( J:379589 )

hematopoietic system

microgliosis ( J:379589 )

• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis

cellular

astrocytosis ( J:379589 )

• GFAP staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased astrocytosis

microgliosis ( J:379589 )

• Iba1 staining is more intense in the periventricular areas of the brain of 6-week-old mice, indicating increased microgliosis

mortality/aging

mortality/aging ( J:379589 )

N	• mice exhibit normal survival, development and body size

behavior/neurological

behavior/neurological phenotype ( J:379589 )

N	• mice do not exhibit neurologic phenotypes, with normal startle response and gait, and no muscle spasms, dystonia or seizures

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Aicardi-Goutieres syndrome		DOID:0050629	OMIM:225750 OMIM:610181 OMIM:610329 OMIM:610333 OMIM:612952 OMIM:615010 OMIM:615846 OMIM:PS225750	J:379589

Allelic Composition	Adar^em1Dmsc/Adar⁺ Ifih1^tm1.1Cln/Ifih1^tm1.1Cln
Genetic Background	involves: 129X1/SvJ * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adar^em1Dmsc mutation (0 available); any Adar mutation (83 available)
Ifih1^tm1.1Cln mutation (5 available); any Ifih1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:379589 )

N	• expression of IFN stimulated gene (ISG) mRNAs in brain of 2-week-old mice is comparable to wild-type controls, indicating rescue of the brain inflammation phenotype seen in single Adar^em1Dmsc heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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