Adar^tm1.1Knk
Targeted Allele Detail

Summary

• Symbol: Adar^tm1.1Knk
• Name: adenosine deaminase, RNA-specific; targeted mutation 1.1, Kazuko Nishikura
• MGI ID: MGI:3032487
• Synonyms: ADAR1^-
• Gene: Adar Location: Chr3:89622329-89660753 bp, + strand Genetic Position: Chr3, 39.19 cM, cytoband F2
• Alliance: Adar^tm1.1Knk page

Widespread apoptosis in Adar^tm1.1Knk/Adar^tm1.1Knk embryos

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:87714
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: A genomic fragment encompassing exons 12 through 15 was deleted in the germline by cre-mediated recombination of flanking loxP sites located in intron 11 and downstream of exon 15. Protein was undetected by immunostaining and Western blot analysis of homozygous mutant embryos. (J:87714)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adar Mutation: 71 strains or lines available

References

• Original: J:87714 Wang Q, et al., Stress-induced apoptosis associated with null mutation of ADAR1 RNA editing deaminase gene. J Biol Chem. 2004 Feb 6;279(6):4952-61
• All: 5 reference(s)