All Phenotypes Foxo1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Foxo1⁺
wild type
MGI:2439691

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Foxo1^{tm1b(EUCOMM)Wtsi}/Foxo1⁺	C57BL/6N-Foxo1^{tm1b(EUCOMM)Wtsi}/J	MGI:6262458
ht2	Foxo1^tm1Whb/Foxo1⁺	Not Specified	MGI:3653867
cn3	Foxo1^tm1.1Rdp/Foxo1⁺ Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0	involves: 129P2/OlaHsd * 129S1/Sv	MGI:4430558
cn4	Foxo1^tm1Whb/Foxo1⁺ Pdpk1^tm1Maka/Pdpk1^tm1Maka Tg(Ins2-cre)23Herr/0	involves: 129S4/SvJae * C57BL/6J * CBA/J	MGI:3629034
cx5	Foxo1^tm1Whb/Foxo1⁺ Irs2^tm1Mfw/Irs2^tm1Mfw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3653870
cx6	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr⁺	involves: 129S4/SvJae * C57BL/6	MGI:3653869
cx7	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr^tm1Dac	involves: 129S4/SvJae * C57BL/6	MGI:3653868

Allelic Composition	Foxo1^{tm1b(EUCOMM)Wtsi}/Foxo1⁺
Genetic Background	C57BL/6N-Foxo1^{tm1b(EUCOMM)Wtsi}/J
Cell Lines	EPD0577_1_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Foxo1 mutation (34 available)

Data Sources

IMPC Data for Foxo1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased aggression ( J:211773 )

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

hematopoietic system

decreased erythrocyte cell number ( J:211773 )

IMPC - JAX

increased mean corpuscular volume ( J:211773 )

IMPC - JAX

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

IMPC - JAX

Allelic Composition	Foxo1^tm1Whb/Foxo1⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Whb mutation (0 available); any Foxo1 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased liver glycogen level ( J:79560 )

• slightly lower hepatic glycogen levels

liver/biliary system

decreased liver glycogen level ( J:79560 )

• slightly lower hepatic glycogen levels

Allelic Composition	Foxo1^tm1.1Rdp/Foxo1⁺ Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1.1Rdp mutation (0 available); any Foxo1 mutation (34 available)
Igh-J^tm1Cgn mutation (3 available); any Igh-J mutation (12 available)
Igh^tm4Cgn mutation (0 available); any Igh mutation (47 available)
Tg(Cr2-cre)3Cgn mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased B cell number ( J:157297 )

• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

hematopoietic system

increased B cell number ( J:157297 )

• mice exhibit a limited rescue of IgM negative B cells compared to in Igh-J^tm1Cgn/Igh^tm4Cgn Tg(Cr2-cre)3Cgn mice

Allelic Composition	Foxo1^tm1Whb/Foxo1⁺ Pdpk1^tm1Maka/Pdpk1^tm1Maka Tg(Ins2-cre)23Herr/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Whb mutation (0 available); any Foxo1 mutation (34 available)
Pdpk1^tm1Maka mutation (0 available); any Pdpk1 mutation (141 available)
Tg(Ins2-cre)23Herr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:109010 )

• double mutants have improved blood glucose levels compared to Pdk1-deficient mice; glucose levels of 200-300 mg/dl are maintained in double mutants at 20-24 weeks

increased circulating insulin level ( J:109010 )

• plasma insulin level is significantly higher in double mutants compared to Pdk1-deficient mice

endocrine/exocrine glands

increased pancreatic beta cell number ( J:109010 )

• Foxo-haploinsufficiency results in a significant increase in beta cell number in double mutants

abnormal pancreas physiology ( J:109010 )

• insulin content of the pancreas in double mutant mice is 6-fold higher than in Pdk1-deficient mice; number of proliferating beta cells is much greater in double mutants compared to Pdk1-null mice

Allelic Composition	Foxo1^tm1Whb/Foxo1⁺ Irs2^tm1Mfw/Irs2^tm1Mfw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Whb mutation (0 available); any Foxo1 mutation (34 available)
Irs2^tm1Mfw mutation (1 available); any Irs2 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:80826 )

N	• near normal pancreatic beta cell area due to improved beta cell proliferation

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:80826 )

N	• no diabetes and normal life span

Allelic Composition	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo1^tm1Whb mutation (0 available); any Foxo1 mutation (34 available)
Insr^tm1Dac mutation (2 available); any Insr mutation (95 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:79560 )

N	• normal insulin and glucose levels at both 2 and 6 months • no diabetes

Allelic Composition	Foxo1^tm1Whb/Foxo1⁺ Insr^tm1Dac/Insr^tm1Dac
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality ( J:79560 )

• due to diabetic ketoacidosis

homeostasis/metabolism

decreased circulating glucose level ( J:79560 )

• 25% reduction in glucose levels relative to Insr^tm1Dac homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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