Phenotypes associated with this allele

• Allele Symbol: Becn1⁺
• Allele Name: wild type
• Allele ID: MGI:2439450
• Summary: 9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Becn1^tm1b(KOMP)Wtsi/Becn1^+	C57BL/6N-Becn1^tm1b(KOMP)Wtsi/Ieg	MGI:6261972
ht2	Becn1^tm1Htz/Becn1^+	involves: 129P2/OlaHsd * C57BL/6	MGI:2683842
ht3	Becn1^tm1Blev/Becn1^+	involves: 129X1/SvJ * C57BL/6J	MGI:2683698
ht4	Becn1^tm1.1Ebr/Becn1^+	Not Specified	MGI:5308736
cn5	Becn1^tm1Ebr/Becn1^+ Tg(MMTV-cre)1Mam/?	involves: FVB	MGI:5308737
cn6	Becn1^tm1Ebr/Becn1^+ Tg(EIIa-cre)C5379Lmgd/?	involves: FVB/N	MGI:5308738
cx7	Becn1^tm1Blev/Becn1^+ Tg(Alb1HBV)44Bri/0	involves: 129X1/SvJ * C57BL/6J	MGI:2683697
cx8	Becn1^tm1Blev/Becn1^+ Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj	MGI:3837449
cx9	Becn1^tm1Blev/Becn1^+ Tg(CAG-EGFP/Map1lc3b)53Nmz/0	involves: 129X1/SvJ * C57BL/6NCrj	MGI:5313436

Genotype
MGI:6261972

ht1

• Allelic Composition: Becn1^{tm1b(KOMP)Wtsi}/Becn1⁺
• Genetic Background: C57BL/6N-Becn1^{tm1b(KOMP)Wtsi}/Ieg
• Cell Lines: EPD0168_1_H11

Data Sources

IMPC Data for Becn1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - HMGU

behavior/neurological

increased startle reflex ( J:211773 )

♂

IMPC - HMGU

growth/size/body

decreased lean body mass ( J:211773 )

♀

IMPC - HMGU

hematopoietic system

increased leukocyte cell number ( J:211773 )

IMPC - HMGU

homeostasis/metabolism

increased circulating bilirubin level ( J:211773 )

♀

IMPC - HMGU

decreased circulating HDL cholesterol level ( J:211773 )

♂

IMPC - HMGU

immune system

increased leukocyte cell number ( J:211773 )

IMPC - HMGU

Genotype
MGI:2683842

ht2

• Allelic Composition: Becn1^tm1Htz/Becn1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Increased cancer rate in Becn1^tm1Htz/Becn1⁺ mice

neoplasm

increased tumor incidence ( J:86982 )

• 59% of mutants develop tumors compared to 14% of wild-type mice between 18 and 22 months of age; tumors are larger and of different types than in wild-type

• however, do not observe loss of heterozygosity in tumors

increased hepatocellular carcinoma incidence ( J:86982 )

increased B cell derived lymphoma incidence ( J:86982 )

increased lung adenocarcinoma incidence ( J:86982 )

respiratory system

increased lung adenocarcinoma incidence ( J:86982 )

liver/biliary system

increased hepatocellular carcinoma incidence ( J:86982 )

Genotype
MGI:2683698

ht3

• Allelic Composition: Becn1^tm1Blev/Becn1⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

mortality/aging

decreased tumor-free survival time ( J:86953 )

• mutants show some tumor-associated mortality at 6 to 8 months of age

homeostasis/metabolism

impaired autophagy ( J:86953 )

• germinal center B lymphocytes have fewer autophagic vacuoles than wild-type lymphocytes 10 days after immunization with sheep red blood cells, indicating reduced autophagic activity

neoplasm

increased tumor incidence ( J:86953 )

• 15% of mutants at 13-18 months of age exhibit palpable tumors compared to 1% of wild-type mice

increased mammary gland tumor incidence ( J:86953 )

• proliferative lesions (mammary intraepithelial neoplasia, adenomyoepithelioma, and acinar neoplasia) are present in mammary gland of 13 to 18 month old mutants

increased lung adenoma incidence ( J:86953 )

• mutants have an increased frequency of lung lesions in earlier stages of neoplasia, including hyperplastic alveolar epithelium resembling human atypical adenomatous hyperplasia and bronchioalveolar adenomas composed of monomorphous cells with minimal cytologic atypia

increased lymphoma incidence ( J:86953 )

• develop lymphomas that occur more frequently, at an earlier age, are more likely to present as palpable masses than in wild-type, including diffuse large-cell lymphoma, follicular lymphoma, immunoblastic variant of diffuse large-cell lymphoma, anaplastic plasmacytoma, and histiocytic sarcoma

increased follicular lymphoma incidence ( J:86953 )

increased histiocytic sarcoma incidence ( J:86953 )

increased malignant tumor incidence ( J:86953 )

• mutants have a higher probability of having a malignancy (30%) than wild-type (14%); malignancies do not contain mutations in the wild-type Becn1 allele

increased hepatocellular carcinoma incidence ( J:86953 )

• well-differentiated hepatocellular carcinomas

increased lung carcinoma incidence ( J:86953 )

• greater number of and larger lung carcinomas than in wild-type mice

increased lung adenocarcinoma incidence ( J:86953 )

• lung cancers show features of well-differentiated human papillary adenocarcinomas

increased plasmacytoma incidence ( J:86953 )

• anaplastic plasmacytoma

liver/biliary system

increased hepatocellular carcinoma incidence ( J:86953 )

• well-differentiated hepatocellular carcinomas

respiratory system

increased lung adenoma incidence ( J:86953 )

• mutants have an increased frequency of lung lesions in earlier stages of neoplasia, including hyperplastic alveolar epithelium resembling human atypical adenomatous hyperplasia and bronchioalveolar adenomas composed of monomorphous cells with minimal cytologic atypia

increased lung carcinoma incidence ( J:86953 )

• greater number of and larger lung carcinomas than in wild-type mice

increased lung adenocarcinoma incidence ( J:86953 )

• lung cancers show features of well-differentiated human papillary adenocarcinomas

cellular

impaired autophagy ( J:86953 )

• germinal center B lymphocytes have fewer autophagic vacuoles than wild-type lymphocytes 10 days after immunization with sheep red blood cells, indicating reduced autophagic activity

endocrine/exocrine glands

abnormal mammary gland duct morphology ( J:86953 )

♀ • mammary ducts are frequently abnormal, with multiple layers of epithelial cells and intraluminal collections of epithelial cells

♀ • hyperproliferation of mammary ductal epithelial cells in the terminal end buds

♀ • mammary ducts show increase in DNA synthesis

increased mammary gland tumor incidence ( J:86953 )

• proliferative lesions (mammary intraepithelial neoplasia, adenomyoepithelioma, and acinar neoplasia) are present in mammary gland of 13 to 18 month old mutants

hematopoietic system

increased spleen germinal center number ( J:86953 )

• mutants show an increase in the number of germinal centeres in the spleens following immunization with sheep red blood cells at 2 months of age

increased spleen germinal center size ( J:86953 )

• mutants show an increase in the size of germinal centers in the spleens following immunization with sheep red blood cells at 2 months of age

immune system

abnormal immune system morphology ( J:86953 )

• increase in frequency of extranodal, splenic, and nodal lymphoproliferative disease

increased spleen germinal center number ( J:86953 )

• mutants show an increase in the number of germinal centeres in the spleens following immunization with sheep red blood cells at 2 months of age

increased spleen germinal center size ( J:86953 )

• mutants show an increase in the size of germinal centers in the spleens following immunization with sheep red blood cells at 2 months of age

integument

abnormal mammary gland duct morphology ( J:86953 )

♀ • mammary ducts are frequently abnormal, with multiple layers of epithelial cells and intraluminal collections of epithelial cells

♀ • hyperproliferation of mammary ductal epithelial cells in the terminal end buds

♀ • mammary ducts show increase in DNA synthesis

increased mammary gland tumor incidence ( J:86953 )

• proliferative lesions (mammary intraepithelial neoplasia, adenomyoepithelioma, and acinar neoplasia) are present in mammary gland of 13 to 18 month old mutants

Genotype
MGI:5308736

ht4

• Allelic Composition: Becn1^tm1.1Ebr/Becn1⁺
• Genetic Background: Not Specified

reproductive system

abnormal ovary morphology ( J:180916 )

♀ • half as many germ cells in 1 day old ovaries as in ovaries of controls

endocrine/exocrine glands

abnormal ovary morphology ( J:180916 )

♀ • half as many germ cells in 1 day old ovaries as in ovaries of controls

Genotype
MGI:5308737

cn5

• Allelic Composition: Becn1^tm1Ebr/Becn1⁺; Tg(MMTV-cre)1Mam/?
• Genetic Background: involves: FVB

mortality/aging

perinatal lethality ( J:180916 )

• only 2 of 100 neonates survive through day 1

embryonic lethality during organogenesis, incomplete penetrance ( J:180916 )

• high level of death associated with heart and brain defects at embryonic days 11.5 and 12.5

reproductive system

abnormal primordial ovarian follicle morphology ( J:180916 )

♀ • non uniform distribution of primordial follicles

decreased primordial ovarian follicle number ( J:180916 )

♀ • reduced number of primordial follicles

small ovary ( J:180916 )

♀

cardiovascular system

abnormal heart development ( J:180916 )

• high level of death associated with heart defects at embryonic days 11.5 and 12.5

nervous system

abnormal brain development ( J:180916 )

• high level of death associated with brain defects at embryonic days 11.5 and 12.5

endocrine/exocrine glands

abnormal primordial ovarian follicle morphology ( J:180916 )

♀ • non uniform distribution of primordial follicles

decreased primordial ovarian follicle number ( J:180916 )

♀ • reduced number of primordial follicles

small ovary ( J:180916 )

♀

Genotype
MGI:5308738

cn6

• Allelic Composition: Becn1^tm1Ebr/Becn1⁺; Tg(EIIa-cre)C5379Lmgd/?
• Genetic Background: involves: FVB/N

mortality/aging

embryonic lethality during organogenesis, incomplete penetrance ( J:180916 )

• high level of death associated with heart and brain defects at embryonic days 11.5 and 12.5

cardiovascular system

abnormal heart development ( J:180916 )

• high level of death associated with heart defects at embryonic days 11.5 and 12.5

nervous system

abnormal brain development ( J:180916 )

• high level of death associated with brain defects at embryonic days 11.5 and 12.5

Genotype
MGI:2683697

cx7

• Allelic Composition: Becn1^tm1Blev/Becn1⁺; Tg(Alb1HBV)44Bri/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

neoplasm

increased tumor incidence ( J:86953 )

• mutants exhibit accelerated development of HBV-induced premalignant lesions compared to hemizygous Tg(Alb1HBV)44Bri mice

Genotype
MGI:3837449

cx8

• Allelic Composition: Becn1^tm1Blev/Becn1⁺; Tg(CAG-EGFP/Map1lc3b)53Nmz/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6J * C57BL/6NCrj

cellular

impaired autophagy ( J:86953 )

• mutants show decreased autophagy during starvation conditions in muscle and bronchial epithelial cells

homeostasis/metabolism

impaired autophagy ( J:86953 )

• mutants show decreased autophagy during starvation conditions in muscle and bronchial epithelial cells

Genotype
MGI:5313436

cx9

• Allelic Composition: Becn1^tm1Blev/Becn1⁺; Tg(CAG-EGFP/Map1lc3b)53Nmz/0
• Genetic Background: involves: 129X1/SvJ * C57BL/6NCrj

cellular

impaired autophagy ( J:181308 )

• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

homeostasis/metabolism

impaired exercise endurance ( J:181308 )

• mice exhibit decreased maximal treadmill running distance compared with wild-type mice

impaired autophagy ( J:181308 )

• reduced exercised-induced autophagy in skeletal muscles compared to in wild-type muscles

behavior/neurological

impaired exercise endurance ( J:181308 )

• mice exhibit decreased maximal treadmill running distance compared with wild-type mice