Phenotypes associated with this allele

• Allele Symbol: Osr2⁺
• Allele Name: wild type
• Allele ID: MGI:2439260
• Summary: 11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Osr2^tm2(cre)Jian/Osr2^+	involves: 129S1/Sv * C57BL/6	MGI:3768550
ht2	Osr2^tm1Pzg/Osr2^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:4441463
cn3	Gsk3b^tm1.1Ypc/Gsk3b^tm1.1Ypc Osr2^tm2(cre)Jian/Osr2^+	involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:4867293
cn4	Hand2^tm1Cse/Hand2^tm1Cse Osr2^tm2(cre)Jian/Osr2^+	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6	MGI:3848961
cn5	Osr2^tm2(cre)Jian/Osr2^+ Tg(CAG-Nog)1Ych/0	involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6	MGI:3848966
cn6	Ctnnb1^tm2Kem/Ctnnb1^tm2Kem Osr2^tm2(cre)Jian/Osr2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:5003151
cn7	Ctnnb1^tm2Kem/Ctnnb1^+ Osr2^tm2(cre)Jian/Osr2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:4365782
cn8	Mapk1^tm1Gela/Mapk1^tm1Gela Osr2^tm2(cre)Jian/Osr2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5902465
cn9	Osr2^tm2(cre)Jian/Osr2^+ Tg(CAG-Bmp4,-EGFP)1Ypc/0	involves: 129S1/Sv * C57BL/6J * CD-1	MGI:6110830
cn10	Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt Osr2^tm5(cre)Jian/Osr2^+	involves: 129X1/SvJ	MGI:4365781
cn11	Osr2^tm5(cre)Jian/Osr2^+ Tg(CAG-Nog)1Ych/0	Not Specified	MGI:7345566

Genotype
MGI:3768550

ht1

• Allelic Composition: Osr2^tm2(cre)Jian/Osr2⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:128736 )

• mice do not display any obvious defects

Genotype
MGI:4441463

ht2

• Allelic Composition: Osr2^tm1Pzg/Osr2⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:159099 )

• mice heterozygous for this mutation are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities

Genotype
MGI:4867293

cn3

• Allelic Composition: Gsk3b^tm1.1Ypc/Gsk3b^tm1.1Ypc; Osr2^tm2(cre)Jian/Osr2⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6

mortality/aging

mortality/aging ( J:166721 )

N • unlike germline null mice, mice survive postnatally

craniofacial

craniofacial phenotype ( J:166721 )

N • unlike in germline null mice, palate formation is normal

Genotype
MGI:3848961

cn4

• Allelic Composition: Hand2^tm1Cse/Hand2^tm1Cse; Osr2^tm2(cre)Jian/Osr2⁺
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

craniofacial

mandible hypoplasia ( J:149232 )

• mandible is hypoplastic

• cleft palate is not observed

skeleton

mandible hypoplasia ( J:149232 )

• mandible is hypoplastic

• cleft palate is not observed

growth/size/body

mandible hypoplasia ( J:149232 )

• mandible is hypoplastic

• cleft palate is not observed

Genotype
MGI:3848966

cn5

• Allelic Composition: Osr2^tm2(cre)Jian/Osr2⁺; Tg(CAG-Nog)1Ych/0
• Genetic Background: involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6

craniofacial

abnormal mandible morphology ( J:149232 )

cleft palate ( J:149232 )

skeleton

abnormal mandible morphology ( J:149232 )

digestive/alimentary system

cleft palate ( J:149232 )

growth/size/body

abnormal mandible morphology ( J:149232 )

cleft palate ( J:149232 )

Genotype
MGI:5003151

cn6

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1^tm2Kem; Osr2^tm2(cre)Jian/Osr2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

skeleton

abnormal joint morphology ( J:171478 )

• at E13.5, joints are not as clearly organized as in wild-type mice

Genotype
MGI:4365782

cn7

• Allelic Composition: Ctnnb1^tm2Kem/Ctnnb1⁺; Osr2^tm2(cre)Jian/Osr2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

skeleton

abnormal enamel knot morphology ( J:153554 )

• unlike in wild-type mice, strong Caspase3 activity is detected in the enamel knot cells of the maxillary and mandibular first molar tooth germs at E14.5

• however, no increase in cell death in tooth epithelium and mesenchyme is detected

growth retardation of incisors ( J:153554 )

• incisor development arrests at bud stage

growth retardation of molars ( J:153554 )

• molar development arrests at bud stage

mortality/aging

neonatal lethality ( J:153554 )

craniofacial

abnormal enamel knot morphology ( J:153554 )

• unlike in wild-type mice, strong Caspase3 activity is detected in the enamel knot cells of the maxillary and mandibular first molar tooth germs at E14.5

• however, no increase in cell death in tooth epithelium and mesenchyme is detected

growth retardation of incisors ( J:153554 )

• incisor development arrests at bud stage

growth retardation of molars ( J:153554 )

• molar development arrests at bud stage

cleft secondary palate ( J:153554 )

digestive/alimentary system

cleft secondary palate ( J:153554 )

growth/size/body

abnormal enamel knot morphology ( J:153554 )

• unlike in wild-type mice, strong Caspase3 activity is detected in the enamel knot cells of the maxillary and mandibular first molar tooth germs at E14.5

• however, no increase in cell death in tooth epithelium and mesenchyme is detected

growth retardation of incisors ( J:153554 )

• incisor development arrests at bud stage

growth retardation of molars ( J:153554 )

• molar development arrests at bud stage

cleft secondary palate ( J:153554 )

Genotype
MGI:5902465

cn8

• Allelic Composition: Mapk1^tm1Gela/Mapk1^tm1Gela; Osr2^tm2(cre)Jian/Osr2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

craniofacial

craniofacial phenotype ( J:239772 )

N • newborns do not exhibit cleft palate and tongues and mandibles are unaffected

Genotype
MGI:6110830

cn9

• Allelic Composition: Osr2^tm2(cre)Jian/Osr2⁺; Tg(CAG-Bmp4,-EGFP)1Ypc/0
• Genetic Background: involves: 129S1/Sv * C57BL/6J * CD-1

craniofacial

palatal shelves fail to meet at midline ( J:214763 )

• at the anterior level, the palatal shelves elevate but fail to contact

• however, origin of palatal shelves form the maxillary processes remains unaltered

palatal shelf fusion with tongue or mandible ( J:214763 )

• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible

cleft palate ( J:214763 )

digestive/alimentary system

palatal shelves fail to meet at midline ( J:214763 )

• at the anterior level, the palatal shelves elevate but fail to contact

• however, origin of palatal shelves form the maxillary processes remains unaltered

palatal shelf fusion with tongue or mandible ( J:214763 )

• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible

cleft palate ( J:214763 )

growth/size/body

palatal shelves fail to meet at midline ( J:214763 )

• at the anterior level, the palatal shelves elevate but fail to contact

• however, origin of palatal shelves form the maxillary processes remains unaltered

palatal shelf fusion with tongue or mandible ( J:214763 )

• at the posterior level, the palatal shelves remain at the vertical orientation, showing abnormal fusion with the mandible

cleft palate ( J:214763 )

Genotype
MGI:4365781

cn10

• Allelic Composition: Ctnnb1^tm1Mmt/Ctnnb1^tm1Mmt; Osr2^tm5(cre)Jian/Osr2⁺
• Genetic Background: involves: 129X1/SvJ

mortality/aging

neonatal lethality ( J:153554 )

craniofacial

abnormal tooth development ( J:153554 )

• E13.5 tooth germs transplanted under the kidney capsule of adult mice for 3 weeks deposit little enamel matrix with premature differentiation of dental pulp cells and large amounts of dentin-like matrix unlike similarly treated wild-type tooth germs

• at E16.5, multiple epithelial invaginations are detected in the nasal side of the developing palatal shelves unlike in wild-type mice

• at E17.5 to P0, ectopic epithelial invaginations at the nasal side of the palatal shelves form morphologically distinct epithelial buds unlike in wild-type mice

• at birth, dental mesenchyme is abnormal

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

cleft palate ( J:153554 )

embryo

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

digestive/alimentary system

cleft palate ( J:153554 )

growth/size/body

abnormal tooth development ( J:153554 )

• E13.5 tooth germs transplanted under the kidney capsule of adult mice for 3 weeks deposit little enamel matrix with premature differentiation of dental pulp cells and large amounts of dentin-like matrix unlike similarly treated wild-type tooth germs

• at E16.5, multiple epithelial invaginations are detected in the nasal side of the developing palatal shelves unlike in wild-type mice

• at E17.5 to P0, ectopic epithelial invaginations at the nasal side of the palatal shelves form morphologically distinct epithelial buds unlike in wild-type mice

• at birth, dental mesenchyme is abnormal

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

cleft palate ( J:153554 )

skeleton

abnormal tooth development ( J:153554 )

• E13.5 tooth germs transplanted under the kidney capsule of adult mice for 3 weeks deposit little enamel matrix with premature differentiation of dental pulp cells and large amounts of dentin-like matrix unlike similarly treated wild-type tooth germs

• at E16.5, multiple epithelial invaginations are detected in the nasal side of the developing palatal shelves unlike in wild-type mice

• at E17.5 to P0, ectopic epithelial invaginations at the nasal side of the palatal shelves form morphologically distinct epithelial buds unlike in wild-type mice

• at birth, dental mesenchyme is abnormal

abnormal dental mesenchyme morphology ( J:153554 )

• at birth, dental mesenchyme is abnormal

Genotype
MGI:7345566

cn11

• Allelic Composition: Osr2^tm5(cre)Jian/Osr2⁺; Tg(CAG-Nog)1Ych/0
• Genetic Background: Not Specified

craniofacial

abnormal secondary palate development ( J:310908 )

• shelves are separated from each other and smaller at E14.5 and E16.5

• extraversive hypophosphatasia

• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5

• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels

• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate

palatal shelf hypoplasia ( J:310908 )

• hypoplastic muscle tissue

abnormal palatine aponeurosis morphology ( J:310908 )

• expression analysis indicates impaired development of the aponeurosis of the soft palate

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

muscle

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

abnormal superior pharyngeal constrictor muscle morphology ( J:310908 )

• at E16.5 the superior pharyngeal constrictor is smaller with fewer myofibers

digestive/alimentary system

abnormal secondary palate development ( J:310908 )

• shelves are separated from each other and smaller at E14.5 and E16.5

• extraversive hypophosphatasia

• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5

• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels

• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate

palatal shelf hypoplasia ( J:310908 )

• hypoplastic muscle tissue

abnormal palatine aponeurosis morphology ( J:310908 )

• expression analysis indicates impaired development of the aponeurosis of the soft palate

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

growth/size/body

abnormal secondary palate development ( J:310908 )

• shelves are separated from each other and smaller at E14.5 and E16.5

• extraversive hypophosphatasia

• significant decrease in both muscle and mesenchymal cell proliferation at the tensor veli palatini and levator veli palatini levels at E13.5 and E14.5

• increase in apoptosis at the the tensor veli palatini, levator veli palatini, and palatopharyngeus levels

• expression analysis indicates impaired development of the aponeurosis and tendons of the soft palate

palatal shelf hypoplasia ( J:310908 )

• hypoplastic muscle tissue

abnormal palatine aponeurosis morphology ( J:310908 )

• expression analysis indicates impaired development of the aponeurosis of the soft palate

small levator veli palatini muscle ( J:310908 )

• only a few sparsely distributed myofibers are present at E14.5

• at E16.5, myofibers become even looser and shorter compared to E14.5

abnormal palatopharyngeus muscle morphology ( J:310908 )

• at E16.5 the palatopharyngeus is smaller with fewer myofibers

small tensor veli palatini muscle ( J:310908 )

• mildly smaller at E14.5 and dramatically smaller at E16.5

respiratory system

abnormal superior pharyngeal constrictor muscle morphology ( J:310908 )

• at E16.5 the superior pharyngeal constrictor is smaller with fewer myofibers