All Phenotypes Runx3<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Runx3⁺
wild type
MGI:2438561

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Runx3^{tm1b(KOMP)Wtsi}/Runx3⁺	C57BL/6N-Runx3^{tm1b(KOMP)Wtsi}/J	MGI:6263408
cn2	Runx3^tm1Itan/Runx3⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0	involves: 129P2/OlaHsd * C57BL/6 * CD-1	MGI:7485833
cn3	Runx1^tm1Toku/Runx1^tm1Toku Runx3^tm1Itan/Runx3⁺ Tg(Cd4-cre)1Cwi/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:3776111
cn4	Dynlrb1^{tm1c(EUCOMM)Wtsi}/Dynlrb1^{tm1c(EUCOMM)Wtsi} Runx3^{tm6(EGFP/cre)Yg}/Runx3⁺	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N	MGI:6466702

Allelic Composition	Runx3^{tm1b(KOMP)Wtsi}/Runx3⁺
Genetic Background	C57BL/6N-Runx3^{tm1b(KOMP)Wtsi}/J
Cell Lines	EPD0663_2_B04

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3^{tm1b(KOMP)Wtsi} mutation (1 available); any Runx3 mutation (28 available)

Data Sources

IMPC Data for Runx3

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal locomotor behavior ( J:211773 )

IMPC - JAX

Allelic Composition	Runx3^tm1Itan/Runx3⁺ Trp53^tm1Brn/Trp53^tm1Brn Tg(Sp7-tTA,tetO-EGFP/cre)1Amc/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx3^tm1Itan mutation (1 available); any Runx3 mutation (28 available)
Tg(Sp7-tTA,tetO-EGFP/cre)1Amc mutation (7 available)
Trp53^tm1Brn mutation (20 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

decreased osteosarcoma incidence ( J:319454 )

• decreased incidence compared to mutant mice wild-type for Runx3

mortality/aging

increased tumor-free survival time ( J:319454 )

• increased lifespan compared to mutant mice wild-type for Runx3

skeleton

decreased osteosarcoma incidence ( J:319454 )

• decreased incidence compared to mutant mice wild-type for Runx3

Allelic Composition	Runx1^tm1Toku/Runx1^tm1Toku Runx3^tm1Itan/Runx3⁺ Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1Toku mutation (0 available); any Runx1 mutation (34 available)
Runx3^tm1Itan mutation (1 available); any Runx3 mutation (28 available)
Tg(Cd4-cre)1Cwi mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:131081 )

• significantly lower than in controls

decreased CD8-positive, alpha-beta T cell number ( J:131081 )

• lower than in controls

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:131081 )

• significantly lower than in controls

decreased CD8-positive, alpha-beta T cell number ( J:131081 )

• lower than in controls

Allelic Composition	Dynlrb1^{tm1c(EUCOMM)Wtsi}/Dynlrb1^{tm1c(EUCOMM)Wtsi} Runx3^{tm6(EGFP/cre)Yg}/Runx3⁺
Genetic Background	involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6N
Cell Lines	EPD0373_7_C01

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dynlrb1^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Dynlrb1 mutation (15 available)
Runx3^{tm6(EGFP/cre)Yg} mutation (0 available); any Runx3 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

limb grasping ( J:292124 )

• adult mice show an abnormal clenched hind-limb phenotype when suspended by the tail

abnormal motor coordination/balance ( J:292124 )

• adult mice exhibit impaired proprioception

impaired balance ( J:292124 )

• adult mice are unable to balance themselves on an accelerating rotarod

abnormal gait ( J:292124 )

• adult mice show an uncoordinated walking pattern with abdomen posture close to the ground and display an abnormal walking pattern in the catwalk

decreased locomotor activity ( J:292124 )

• adult mice exhibit reduced speed and less distance traveled than wild type controls in the open field

• however, basal motor activity is normal

nervous system

nervous system phenotype ( J:292124 )

N	• mice show no significant alterations in neuromuscular junction size or numbers and in total (Tuj1 positive) or nociceptive (CGRP positive) skin innervation

abnormal proprioceptive neuron morphology ( J:292124 )

• the number of proprioceptive NFH-positive neurons in DRG ganglia is significantly decreased

• however, the number of CGRP-positive nociceptive neurons is normal

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