Analysis Tools|
Allele Symbol Allele Name Allele ID |
Mapk3+ wild type MGI:2438216 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• adult male and female mice show no significant differences in any of the brain neuroanatomical parameters measured on two coronal sections (at bregma +0.98 mm and bregma -1.34 mm) in five major categories (brain size, commissure, ventricle, cortex, and subcortex) relative wild-type controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• adult male mice show no major behavioral deficits in a broad range of behavioral tests evaluating anxiety, depression, anhedonia, memory, locomotion, coordination, motricity, sociability, schizophrenia, autism, and epilepsy
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more severe than in mice with normal Mapk3
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• more severe than in mice with normal Mapk3
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• more severe than in mice with normal Mapk3
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• more severe than in mice with normal Mapk3
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• in 3 of 3 mice at E16.5 and E17.5
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• in 3 of 3 mice at E16.5 and E17.5
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• single-lobed, fused and misplaced
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• singled-lobed and medially localized
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• more severe than in mice with normal Mapk3
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• single-lobed, fused and misplaced
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• single-lobed, fused and misplaced
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• more severe than in mice with normal Mapk3
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• more severe than in mice with normal Mapk3
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• all mice died by E14.5
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• endocardial cushion volume is increased compared to in wild-type mice but not as severely as in Tg(CAG-cat,-Ptpn11*Q97R)1Rbns Tg(Tek-cre)12Flv mice
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• mice exhibit nuchal edema
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• mice exhibit nuchal edema
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• mice exhibit nuchal edema
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• adult male mice show no major behavioral deficits in motricity, coordination, reward-seeking behaviors, working and short-term memory, associative learning, circadian activity, and no signs of autism and schizophrenic-like behaviors
• adult males show only a non-significant trend of increased latency to immobility in the tail suspension test but no detectable changes in the forced swim test
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• in the pentylenetetrazol (PTZ)-induced seizure paradigm, adult males show a dramatic reduction in the duration of clonic seizures, suggesting resistance to epilepsy
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• adult males spend more time in the open arm of the elevated plus maze than wild-type males
• in the open field paradigm, adult males show increased time spent in the center of the apparatus along with decreased latency to enter the center, suggesting resistance to anxiogenic behavior
• however, no increase in traveled distance is noted in the open field, suggesting normal basic activity
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• adult males show decreased freezing time in contextual and cued fear conditioning
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• in the pentylenetetrazol (PTZ)-induced seizure paradigm, adult males show a dramatic reduction in the duration of clonic seizures, suggesting resistance to epilepsy
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N |
• adult male mice exhibit normal body weight from 11 to 25 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 03/25/2025 MGI 6.24 |
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