All Phenotypes Cx3cr1<+> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cx3cr1^tm1Litt/Cx3cr1⁺	B6.129P2-Cx3cr1^tm1Litt	MGI:4833985
cn2	Cx3cr1^{tm1.1(cre)Jung}/Cx3cr1⁺ Sqor^em1Chji/Sqor^em1Chji	B6(Cg)-Sqor^em1Chji Cx3cr1^{tm1.1(cre)Jung}	MGI:6818637
cn3	Gpr35^em2Niess/Gpr35^em2Niess Cx3cr1^{tm2.1(cre/ERT2)Litt}/Cx3cr1⁺	involves: 129P2/OlaHsd * C57BL/6N	MGI:6502846
cx4	Apoe^tm1Unc/Apoe^tm1Unc Cx3cr1^tm1Zm/Cx3cr1⁺	B6.129-Apoe^tm1Unc Cx3cr1^tm1Zm	MGI:3618279
cx5	Cx3cr1^tm1Litt/Cx3cr1⁺ Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSwe,tauP301L)1Lfa/0 Tg(Thy1-YFP)HJrs/0	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA	MGI:4834197
cx6	Cx3cr1^{tm2.1(cre/ERT2)Litt}/Cx3cr1⁺ Vps35^{Gt(RRK261)Byg}/Vps35^{Gt(RRK261)Byg}	involves: 129P2/OlaHsd * C57BL/6	MGI:6450125
cx7	Ccr2^tm2.1Ifc/Ccr2^tm2.1Ifc Cx3cr1^tm1Litt/Cx3cr1⁺	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4868437

Allelic Composition	Cx3cr1^tm1Litt/Cx3cr1⁺
Genetic Background	B6.129P2-Cx3cr1^tm1Litt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1^tm1Litt mutation (6 available); any Cx3cr1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

microgliosis ( J:110266 )

• moderate following LPS exposure

immune system

microgliosis ( J:110266 )

• moderate following LPS exposure

increased susceptibility to experimental autoimmune encephalomyelitis ( J:129712 )

• following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit intermediate EAE severity (including transient flaccid paresis) compared with homozygous and wild-type mice

• mice treated with anti-NK1.1 antibodies exhibit the same severity of EAE as in homozygous mice following induction of experimental autoimmune encephalomyelitis

behavior/neurological

paresis ( J:129712 )

• following induction of experimental autoimmune encephalomyelitis, mice exhibit transient flaccid paresis

hematopoietic system

microgliosis ( J:110266 )

• moderate following LPS exposure

cellular

microgliosis ( J:110266 )

• moderate following LPS exposure

Allelic Composition	Cx3cr1^{tm1.1(cre)Jung}/Cx3cr1⁺ Sqor^em1Chji/Sqor^em1Chji
Genetic Background	B6(Cg)-Sqor^em1Chji Cx3cr1^{tm1.1(cre)Jung}

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1^{tm1.1(cre)Jung} mutation (2 available); any Cx3cr1 mutation (49 available)
Sqor^em1Chji mutation (0 available); any Sqor mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to xenobiotic ( J:314187 )

• in an intracerebral hemorrhage model induced by collagenase injection into the left striatum, mice show no therapeutic effects of ADT-OH [5-(4-hydroxyphenyl)-3H-1, 2-dithiole-3-thione] as is seen in controls

Allelic Composition	Gpr35^em2Niess/Gpr35^em2Niess Cx3cr1^{tm2.1(cre/ERT2)Litt}/Cx3cr1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1^{tm2.1(cre/ERT2)Litt} mutation (2 available); any Cx3cr1 mutation (49 available)
Gpr35^em2Niess mutation (0 available); any Gpr35 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

decreased colon length ( J:300275 )

• in mice treated with tamoxifen and DSS

• however, treatment with TNF attenuates exacerbated DSS-induced colon reduction

increased susceptibility to induced colitis ( J:300275 )

• in mice treated with tamoxifen and DSS with increased body weight loss, disease activity scores, and enteroscopic and histological colitis scores, and reduced colon length that are not responsive to LPA treatment

• increased inflammation is not associated with higher macrophage infiltration into the colonic lamina prioria in mice treated with tamoxifen and DSS

• however, treatment with TNF attenuates exacerbated DSS-induced colitis

growth/size/body

increased susceptibility to weight loss ( J:300275 )

• in mice treated with tamoxifen and DSS

• however, treatment with TNF attenuates exacerbated DSS-induced weight loss

immune system

increased susceptibility to induced colitis ( J:300275 )

• increased inflammation is not associated with higher macrophage infiltration into the colonic lamina prioria in mice treated with tamoxifen and DSS

• however, treatment with TNF attenuates exacerbated DSS-induced colitis

homeostasis/metabolism

abnormal corticosterone level ( J:300275 )

• lower corticosterone concentrations from the supernatants of colonic explants of mice treated with tamoxifen and DSS

• however, treatment with TNF increases corticosterone concentrations from the supernatants of colonic explants of mice treated with tamoxifen and DSS

Allelic Composition	Apoe^tm1Unc/Apoe^tm1Unc Cx3cr1^tm1Zm/Cx3cr1⁺
Genetic Background	B6.129-Apoe^tm1Unc Cx3cr1^tm1Zm

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoe^tm1Unc mutation (35 available); any Apoe mutation (164 available)
Cx3cr1^tm1Zm mutation (1 available); any Cx3cr1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

decreased susceptibility to atherosclerosis ( J:103047 )

• lesion area in the thoracic aorta is decreased by about 50% compared to mice homozygous for the Apoe allele only

Allelic Composition	Cx3cr1^tm1Litt/Cx3cr1⁺ Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSwe,tauP301L)1Lfa/0 Tg(Thy1-YFP)HJrs/0
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cx3cr1^tm1Litt mutation (6 available); any Cx3cr1 mutation (49 available)
Psen1^tm1Mpm mutation (4 available); any Psen1 mutation (61 available)
Tg(APPSwe,tauP301L)1Lfa mutation (3 available)
Tg(Thy1-YFP)HJrs mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal microglial cell morphology ( J:159680 )

• microglial density increases over time around lost neurons unlike in Cx3cr1^tm1Litt/Cx3cr1^tm1Litt Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice

abnormal microglial cell physiology ( J:159680 )

• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1^tm1Litt heterozygotes and homozygotes

neuron degeneration ( J:159680 )

• of YFP+ layer III neurons at 4 to 6 months

immune system

abnormal microglial cell morphology ( J:159680 )

• microglial density increases over time around lost neurons unlike in Cx3cr1^tm1Litt/Cx3cr1^tm1Litt Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice

abnormal microglial cell physiology ( J:159680 )

• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1^tm1Litt heterozygotes and homozygotes

hematopoietic system

abnormal microglial cell morphology ( J:159680 )

• microglial density increases over time around lost neurons unlike in Cx3cr1^tm1Litt/Cx3cr1^tm1Litt Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice

abnormal microglial cell physiology ( J:159680 )

• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1^tm1Litt heterozygotes and homozygotes

cellular

abnormal microglial cell morphology ( J:159680 )

• microglial density increases over time around lost neurons unlike in Cx3cr1^tm1Litt/Cx3cr1^tm1Litt Psen1^tm1Mpm/Psen1^tm1Mpm Tg(APPSwe,tauP301L)1Lfa mice

abnormal microglial cell physiology ( J:159680 )

• microglia migration velocity around lost neurons is 2-fold greater than in Cx3cr1^tm1Litt heterozygotes and homozygotes

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

microgliosis ( J:292365 )

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased neuron apoptosis ( J:292365 )

• after induced cortical ischemic stroke following tamoxifen-induced knockout

• decreased severity of motor function deficits after cortical ischemic stroke induced close to sensorimotor cortex following tamoxifen-induced knockout

hematopoietic system

microgliosis ( J:292365 )

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

increased macrophage cell number ( J:292365 )

• increased number of macrophages in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of macrophages in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

homeostasis/metabolism

increased transforming growth factor beta level ( J:292365 )

• increased expression of TGFB in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased cerebral infarct size ( J:292365 )

• after induced cortical ischemic stroke following tamoxifen-induced knockout

immune system

microgliosis ( J:292365 )

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

increased macrophage cell number ( J:292365 )

• increased number of macrophages in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of macrophages in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased interleukin-1 beta secretion ( J:292365 )

• reduced expression of IL1B in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

increased interleukin-10 secretion ( J:292365 )

• increased expression of IL10 in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

increased interleukin-4 secretion ( J:292365 )

• increased expression of IL4 in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased interleukin-6 secretion ( J:292365 )

• reduced expression of IL6 in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased tumor necrosis factor secretion ( J:292365 )

• reduced expression of TNFA in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:292365 )

• decreased cortex infarction size after induced cortical ischemic stroke following tamoxifen-induced knockout

• decreased neuronal cell death after induced cortical ischemic stroke following tamoxifen-induced knockout

• decreased severity of motor function deficits after cortical ischemic stroke induced close to sensorimotor cortex following tamoxifen-induced knockout

• lower increase of astrocyte number (reduced astrocytosis) in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• reduced number of pro-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

nervous system

microgliosis ( J:292365 )

• increased number of anti-inflammatory microglia in periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• increased number of microglia in ipsilateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

• normal number of microglia in contralateral periinfarct area after induced cortical ischemic stroke following tamoxifen-induced knockout

decreased neuron apoptosis ( J:292365 )

• after induced cortical ischemic stroke following tamoxifen-induced knockout

• decreased severity of motor function deficits after cortical ischemic stroke induced close to sensorimotor cortex following tamoxifen-induced knockout

decreased cerebral infarct size ( J:292365 )

• after induced cortical ischemic stroke following tamoxifen-induced knockout

Allelic Composition	Ccr2^tm2.1Ifc/Ccr2^tm2.1Ifc Cx3cr1^tm1Litt/Cx3cr1⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2^tm2.1Ifc mutation (2 available); any Ccr2 mutation (44 available)
Cx3cr1^tm1Litt mutation (6 available); any Cx3cr1 mutation (49 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal leukocyte physiology ( J:166664 )

• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:166664 )

• mice exhibit delayed onset and severity of experimental autoimmune encephalomyelitis with reduced monocyte infiltration into the central nervous system and decreased microglial cell activation compared with similarly treated wild-type mice

hematopoietic system

abnormal leukocyte physiology ( J:166664 )

• in a mouse model of thioglycollate-induced peritonitis, monocyte recruitment is reduced compared to in similarly treated wild-type mice

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