Phenotypes associated with this allele

• Allele Symbol: Dkk1⁺
• Allele Name: wild type
• Allele ID: MGI:2437387
• Summary: 9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dkk1^tm1Lmgd/Dkk1^+	involves: 129S1/Sv * 129X1/SvJ	MGI:4947314
cx2	Dkk1^tm1Lmgd/Dkk1^+ Kremen1^tm1Dgen/Kremen1^tm1Dgen Kremen2^tm1Cni/Kremen2^tm1Cni	either: B6.Cg-Kremen1^tm1Dgen Kremen2^tm1Cni Dkk1^tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1)	MGI:3805007
cx3	Ctnnb1^Bfc/Ctnnb1^+ Dkk1^tm1Lmgd/Dkk1^+ Lrp6^Gw/Lrp6^+	either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6)	MGI:4947311
cx4	Ctnnb1^Bfc/Ctnnb1^+ Dkk1^tm1Lmgd/Dkk1^+	either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)	MGI:4947312
cx5	Ctnnb1^Bfc/Ctnnb1^Bfc Dkk1^tm1Lmgd/Dkk1^+	either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)	MGI:4947313
cx6	Dkk1^tm1Lmgd/Dkk1^+ Lrp6^Gw/Lrp6^+	involves: 101/H * 129 * BALB/c * C3H	MGI:4947305
cx7	Dkk1^tm1Lmgd/Dkk1^+ Lrp6^Gw/Lrp6^Gw	involves: 101/H * 129 * BALB/c * C3H	MGI:4947306
cx8	Dkk1^tm1Lmgd/Dkk1^+ Gsc^tm2Bhr/Gsc^tm2Bhr	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3716766
cx9	Dkk1^tm1Lmgd/Dkk1^+ Gsc^tm2Bhr/Gsc^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3716765

Genotype
MGI:4947314

ht1

• Allelic Composition: Dkk1^tm1Lmgd/Dkk1⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

microcephaly ( J:170646 )

• 9% of mice exhibit reduced head compared with wild-type mice

Genotype
MGI:3805007

cx2

• Allelic Composition: Dkk1^tm1Lmgd/Dkk1⁺; Kremen1^tm1Dgen/Kremen1^tm1Dgen; Kremen2^tm1Cni/Kremen2^tm1Cni
• Genetic Background: either: B6.Cg-Kremen1^tm1Dgen Kremen2^tm1Cni Dkk1^tm1Lmgd or (involves: 129S1/Sv * 129X1/SvJ * CD-1)

skeleton

increased bone volume ( J:137914 )

• limb bone volume is increased compared to in wild-type mice but not compared to in Dkk1^tm1Lmgd heterozygotes

limbs/digits/tail

polydactyly ( J:137914 )

• mice have ectopic postaxial forelimb digits

• the frequency and size of ectopic digits is increase compared to in Kremen1^tm1Dgen Kremen2^tm1Cni homozygotes

• 40% of ectopic digits originate at the carpus like regular digits unlike in Kremen1^tm1Dgen Kremen2^tm1Cni homozygotes where ectopic digits originate from digit V

• however, unlike in Dkk1 null mice webbing of bone elements is not observed

Genotype
MGI:4947311

cx3

• Allelic Composition: Ctnnb1^Bfc/Ctnnb1⁺; Dkk1^tm1Lmgd/Dkk1⁺; Lrp6^Gw/Lrp6⁺
• Genetic Background: either: (involves: 101/H * 129 * BALB/cCrl * C3H) or (involves: 101/H * 129 * BALB/cCrl * C3H * C57BL/6)

embryo

caudal body truncation ( J:170646 )

• 23% of mice exhibit complete head truncation unlike wild-type mice

growth/size/body

abnormal head size ( J:170646 )

• all mice exhibit head reduction defects unlike wild-type mice

Genotype
MGI:4947312

cx4

• Allelic Composition: Ctnnb1^Bfc/Ctnnb1⁺; Dkk1^tm1Lmgd/Dkk1⁺
• Genetic Background: either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)

mortality/aging

preweaning lethality, incomplete penetrance ( J:170646 )

• fewer than expected mice are produced

• viability is less than in Ctnnb1^Bfc heterozygotes

vision/eye

abnormal eye morphology ( J:170646 )

• ocular defects are higher than in Ctnnb1^Bfc heterozygotes

growth/size/body

abnormal head morphology ( J:170646 )

• 92% of mice exhibit head defects compared with wild-type mice

• head defects are higher than in Ctnnb1^Bfc heterozygotes

Genotype
MGI:4947313

cx5

• Allelic Composition: Ctnnb1^Bfc/Ctnnb1^Bfc; Dkk1^tm1Lmgd/Dkk1⁺
• Genetic Background: either: (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl) or (involves: 129/Sv * BALB/cCrl * C3H/HeNCrl * C57BL/6)

growth/size/body

abnormal head size ( J:170646 )

• all mice exhibit head reduction defects unlike wild-type mice

Genotype
MGI:4947305

cx6

• Allelic Composition: Dkk1^tm1Lmgd/Dkk1⁺; Lrp6^Gw/Lrp6⁺
• Genetic Background: involves: 101/H * 129 * BALB/c * C3H

limbs/digits/tail

kinked tail ( J:170646 )

• in all mice

growth/size/body

abnormal head morphology ( J:170646 )

• in 40-43% of mice

Genotype
MGI:4947306

cx7

• Allelic Composition: Dkk1^tm1Lmgd/Dkk1⁺; Lrp6^Gw/Lrp6^Gw
• Genetic Background: involves: 101/H * 129 * BALB/c * C3H

growth/size/body

abnormal head morphology ( J:170646 )

• in 79% of mice

Genotype
MGI:3716766

cx8

• Allelic Composition: Dkk1^tm1Lmgd/Dkk1⁺; Gsc^tm2Bhr/Gsc^tm2Bhr
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

embryo

abnormal embryo development ( J:119933 )

• about 75% of embryos at E7.5 - E9.5 display abnormalities that vary in severity

nervous system

decreased forebrain size ( J:119933 )

• at E8.5 and E9.5 variable truncations of the forebrain are seen ranging from mild reduction in head size (14.3% of embryos) to partial loss of the forebrain and ill-defined brain segments (42.8%) and in severely affected embryos (14.3%) anterior truncations resembling those in Dkk1 single homozygotes

vision/eye

abnormal eye development ( J:119933 )

• poor development of the eye primordium in moderately affected embryos (42.8%)

growth/size/body

microcephaly ( J:119933 )

• at E8.5 - E9.5, head size is reduced by 16% compared to wild-type

Genotype
MGI:3716765

cx9

• Allelic Composition: Dkk1^tm1Lmgd/Dkk1⁺; Gsc^tm2Bhr/Gsc⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

nervous system

decreased forebrain size ( J:119933 )

• about 43% of embryos at E7.5 - E9.5 display a mild reduction in forebrain size