Phenotypes associated with this allele

• Allele Symbol: Hdac2⁺
• Allele Name: wild type
• Allele ID: MGI:2436781
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hdac2^em1(IMPC)Kmpc/Hdac2^+	C57BL/6NTac-Hdac2^em1(IMPC)Kmpc/Kmpc	MGI:7629018
ht2	Hdac2^tm1Lex/Hdac2^+	involves: 129S5/SvEvBrd * C57BL/6	MGI:5613708
cn3	Hdac1^tm1.1Mrl/Hdac1^tm1.1Mrl Hdac2^tm1.1Rdp/Hdac2^+ Tg(Mx1-cre)1Cgn/0	involves: 129S4/SvJae * C57BL/6 * CBA	MGI:5494631
cn4	Hdac1^tm1.1Shmc/Hdac1^tm1.1Shmc Hdac2^tm1.1Shmc/Hdac2^+ Tg(Lck-cre)1Cwi/0	involves: 129S7/SvEvBrd	MGI:5485404
cn5	Hdac1^tm1.1Eno/Hdac1^tm1.1Eno Hdac2^tm1.1Eno/Hdac2^+ Tg(KRT14-cre)1Ipc/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:5605729

Genotype
MGI:7629018

ht1

• Allelic Composition: Hdac2^{em1(IMPC)Kmpc}/Hdac2⁺
• Genetic Background: C57BL/6NTac-Hdac2^{em1(IMPC)Kmpc}/Kmpc

Data Sources

IMPC Data for Hdac2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - KMPC

no spontaneous movement ( J:211773 )

IMPC - KMPC

Genotype
MGI:5613708

ht2

• Allelic Composition: Hdac2^tm1Lex/Hdac2⁺
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

vision/eye

decreased susceptilbility to retina ischemic injury ( J:214041 )

• 7 days following ischemic injury, mice exhibit a less significant decrease in ERG waveforms and reduced loss of retinal thickness with only a slight decrease in the inner plexiform layer and inner nuclear layer thickness compared with wild-type mice

abnormal total retina thickness ( J:214041 )

• 7 days following ischemic injury, mice exhibit a reduced loss of retinal thickness compared with wild-type mice

abnormal eye electrophysiology ( J:214041 )

• 7 days following ischemic injury, mice exhibit a less significant decrease in ERG waveforms compared with wild-type mice

• however, baseline readings are normal

homeostasis/metabolism

decreased susceptilbility to retina ischemic injury ( J:214041 )

• 7 days following ischemic injury, mice exhibit a less significant decrease in ERG waveforms and reduced loss of retinal thickness with only a slight decrease in the inner plexiform layer and inner nuclear layer thickness compared with wild-type mice

Genotype
MGI:5494631

cn3

• Allelic Composition: Hdac1^tm1.1Mrl/Hdac1^tm1.1Mrl; Hdac2^tm1.1Rdp/Hdac2⁺; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA

hematopoietic system

anemia ( J:197818 )

• in pIpC-treated mice

decreased bone marrow cell number ( J:197818 )

• in pIpC-treated mice

abnormal megakaryocyte morphology ( J:197818 )

• megakaryocytes from pIpC-treated mice exhibit aberrant nuclear morphology and mitotic figures and are frequently found intra-vascular or extravasating into bone marrow blood vessels and in the liver compared with control cells

decreased megakaryocyte cell number ( J:197818 )

• in the bone marrow of pIpC-treated mice without increased apoptosis

decreased erythrocyte cell number ( J:197818 )

• 2-fold in pIpC-treated mice

thrombocytopenia ( J:197818 )

• 6-fold in pIpC-treated mice

behavior/neurological

lethargy ( J:197818 )

• in pIpC-treated mice

Genotype
MGI:5485404

cn4

• Allelic Composition: Hdac1^tm1.1Shmc/Hdac1^tm1.1Shmc; Hdac2^tm1.1Shmc/Hdac2⁺; Tg(Lck-cre)1Cwi/0
• Genetic Background: involves: 129S7/SvEvBrd

mortality/aging

premature death ( J:194769 )

• all mice die at an average of 15 weeks

immune system

enlarged thymus ( J:194769 )

• in diseased mice

thymus hypoplasia ( J:194769 )

• 5-fold reduction in cellularity in neonates

enlarged spleen ( J:194769 )

• in diseased mice

increased double-negative T cell number ( J:194769 )

• in the percentage but not the absolute numbers

decreased double-positive T cell number ( J:194769 )

increased double-positive T cell number ( J:194769 )

• increase in CD4^low/CD8^high cells at 6 to 8 weeks

arrested T cell differentiation ( J:194769 )

• block at the double negative to double positive transition

decreased CD4-positive, alpha-beta T cell number ( J:194769 )

decreased CD8-positive, alpha-beta T cell number ( J:194769 )

increased single-positive T cell number ( J:194769 )

• 4-fold increase in the percent of immature single positive cells at 6 to 8 weeks

neoplasm

increased tumor incidence ( J:194769 )

• in 1 of 8 mice

growth/size/body

enlarged chest ( J:194769 )

• in moribund mice

distended abdomen ( J:194769 )

• in moribund mice

enlarged spleen ( J:194769 )

• in diseased mice

respiratory system

increased pulmonary respiratory rate ( J:194769 )

• in moribund mice

hematopoietic system

enlarged thymus ( J:194769 )

• in diseased mice

thymus hypoplasia ( J:194769 )

• 5-fold reduction in cellularity in neonates

enlarged spleen ( J:194769 )

• in diseased mice

increased double-negative T cell number ( J:194769 )

• in the percentage but not the absolute numbers

decreased double-positive T cell number ( J:194769 )

increased double-positive T cell number ( J:194769 )

• increase in CD4^low/CD8^high cells at 6 to 8 weeks

arrested T cell differentiation ( J:194769 )

• block at the double negative to double positive transition

decreased CD4-positive, alpha-beta T cell number ( J:194769 )

decreased CD8-positive, alpha-beta T cell number ( J:194769 )

increased single-positive T cell number ( J:194769 )

• 4-fold increase in the percent of immature single positive cells at 6 to 8 weeks

endocrine/exocrine glands

enlarged thymus ( J:194769 )

• in diseased mice

thymus hypoplasia ( J:194769 )

• 5-fold reduction in cellularity in neonates

Genotype
MGI:5605729

cn5

• Allelic Composition: Hdac1^tm1.1Eno/Hdac1^tm1.1Eno; Hdac2^tm1.1Eno/Hdac2⁺; Tg(KRT14-cre)1Ipc/0
• Genetic Background: involves: 129S/SvEv * C57BL/6 * SJL

integument

abnormal coat appearance ( J:205733 )

• double mutants show similar but more obvious hair and skin phenotypes than single Hdac1 conditional homozygotes

• characteristic hair types are replaced by abnormally pigmented, shorter, thinner hairs with misshaped and twisted medulla structures

abnormal nail morphology ( J:205733 )

• mice show more severe supernumerary claw phenotypes than single Hdac1 conditional homozygotes

abnormal nail color ( J:205733 )

• mice show more severe pigmentation in the claws than single Hdac1 conditional homozygotes

abnormal vibrissa morphology ( J:205733 )

• vibrissa hair fiber thickness and length are reduced

short vibrissae ( J:205733 )

abnormal epidermal layer morphology ( J:205733 )

• interfollicular epithelium is hyperpigmented

hyperkeratosis ( J:205733 )

• foot skin epithelium is hyperkeratotic

increased foot pad pigmentation ( J:205733 )

• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes

limbs/digits/tail

increased foot pad pigmentation ( J:205733 )

• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes

pigmentation

increased foot pad pigmentation ( J:205733 )

• mice show more severe pigmentation of the footpads and feet than single Hdac1 conditional homozygotes

vision/eye

narrow eye opening ( J:205733 )