All Phenotypes Dicer1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dicer1⁺
wild type
MGI:2436527

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dicer1^{tm1b(EUCOMM)Wtsi}/Dicer1⁺	C57BL/6N-Dicer1^{tm1b(EUCOMM)Wtsi}/H	MGI:5756992
cn2	Dicer1^tm1Bdh/Dicer1⁺ Yy1^tm2.1Yshi/Yy1⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129 * 129S4/SvJae * C57BL/6	MGI:5902326
cn3	Dicer1^tm1Bdh/Dicer1⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129 * C57BL/6 * CBA/J	MGI:4868201
cn4	Dicer1^tm1Bdh/Dicer1⁺ Tg(Chx10-EGFP/cre,-ALPP)2Clc/0	involves: 129 * C57BL/6 * SJL	MGI:6383085

Allelic Composition	Dicer1^{tm1b(EUCOMM)Wtsi}/Dicer1⁺
Genetic Background	C57BL/6N-Dicer1^{tm1b(EUCOMM)Wtsi}/H
Cell Lines	EPD0597_3_H11

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1^{tm1b(EUCOMM)Wtsi} mutation (1 available); any Dicer1 mutation (96 available)

Data Sources

IMPC Data for Dicer1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - HAR

growth/size/body

decreased lean body mass ( J:211773 )

IMPC - HAR

hematopoietic system

decreased red blood cell distribution width ( J:211773 )

IMPC - HAR

decreased neutrophil cell number ( J:211773 )

IMPC - HAR

decreased spleen weight ( J:211773 )

IMPC - HAR

absent spleen ( J:211773 )

IMPC - HAR

homeostasis/metabolism

increased circulating HDL cholesterol level ( J:211773 )

IMPC - HAR

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - HAR

immune system

decreased neutrophil cell number ( J:211773 )

IMPC - HAR

decreased spleen weight ( J:211773 )

IMPC - HAR

absent spleen ( J:211773 )

IMPC - HAR

vision/eye

abnormal retina morphology ( J:211773 )

IMPC - HAR

Allelic Composition	Dicer1^tm1Bdh/Dicer1⁺ Yy1^tm2.1Yshi/Yy1⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129 * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1^tm1Bdh mutation (6 available); any Dicer1 mutation (96 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (2 available); any Shh mutation (48 available)
Yy1^tm2.1Yshi mutation (0 available); any Yy1 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

respiratory system phenotype ( J:239777 )

N	• embryos do not present lung defects

Allelic Composition	Dicer1^tm1Bdh/Dicer1⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129 * C57BL/6 * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1^tm1Bdh mutation (6 available); any Dicer1 mutation (96 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal thymus development ( J:166758 )

• thymus development is delayed at E14.5, but by E16.5, the thymus is indistinguishable from wild-type

immune system

abnormal thymus development ( J:166758 )

• thymus development is delayed at E14.5, but by E16.5, the thymus is indistinguishable from wild-type

endocrine/exocrine glands

abnormal thymus development ( J:166758 )

• thymus development is delayed at E14.5, but by E16.5, the thymus is indistinguishable from wild-type

Allelic Composition	Dicer1^tm1Bdh/Dicer1⁺ Tg(Chx10-EGFP/cre,-ALPP)2Clc/0
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1^tm1Bdh mutation (6 available); any Dicer1 mutation (96 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:135193 )

N	• no morphological abnormalities are seen in the retina

decreased a-wave amplitude ( J:135193 )

• scotopic a wave amplitude is reduced at 1, 3, and 5 months of age

decreased b-wave amplitude ( J:135193 )

• scotopic and photopic b wave amplitudes are reduced at 1, 3, and 5 months of age

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