All Phenotypes Dbn1<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dbn1⁺
wild type
MGI:2436278

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Dbn1^tm1.1Lbc/Dbn1⁺	B6.Cg-Dbn1^tm1.1Lbc	MGI:5784725
ht2	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6NCrl-Dbn1^{tm1b(KOMP)Wtsi}/Wtsi	MGI:7414857
ht3	Dbn1^{tm1a(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1a(KOMP)Wtsi}/Wtsi	MGI:5705982
ht4	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay	MGI:5767624
ht5	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/H	MGI:5756959
ht6	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ics	MGI:5756963
ht7	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ieg	MGI:5756961
ht8	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/J	MGI:5756962
ht9	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/MbpMmucd	MGI:7471968
ht10	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Rbrc	MGI:5759178
ht11	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ucd	MGI:5756960
ht12	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Wtsi	MGI:5608363

Allelic Composition	Dbn1^tm1.1Lbc/Dbn1⁺
Genetic Background	B6.Cg-Dbn1^tm1.1Lbc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^tm1.1Lbc mutation (0 available); any Dbn1 mutation (44 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal dendritic spine morphology ( J:224553 )

• total number of dendritic spines on apical dendrites of CA1 pyramidal cells is significantly reduced relative to wild-type controls, but to a lesser extent than in homozygous mutants

• significant reduction in the number of mushroom and stubby dendritic spines on CA1 hippocampal neurons, whereas numbers of thin and other unclassified types remain normal

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6NCrl-Dbn1^{tm1b(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:211773 )

IMPC - CCP-IMG

enlarged heart ( J:211773 )

IMPC - CCP-IMG

growth/size/body

enlarged heart ( J:211773 )

IMPC - CCP-IMG

homeostasis/metabolism

increased fasting circulating glucose level ( J:211773 )

IMPC - CCP-IMG

liver/biliary system

abnormal liver morphology ( J:211773 )

IMPC - CCP-IMG

Allelic Composition	Dbn1^{tm1a(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1a(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1a(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

immune system

increased leukocyte cell number ( J:211773 )

IMPC - WTSI

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Bay
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

unresponsive to tactile stimuli ( J:211773 )

IMPC - BCM

decreased vertical activity ( J:211773 )

IMPC - BCM

cardiovascular system

enlarged heart ( J:211773 )

IMPC - BCM

increased heart weight ( J:211773 )

IMPC - BCM

growth/size/body

enlarged heart ( J:211773 )

IMPC - BCM

increased heart weight ( J:211773 )

IMPC - BCM

homeostasis/metabolism

decreased circulating cholesterol level ( J:211773 )

IMPC - BCM

decreased circulating serum albumin level ( J:211773 )

IMPC - BCM

vision/eye

decreased total retina thickness ( J:211773 )

IMPC - BCM

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/H
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal vertebrae morphology ( J:211773 )

IMPC - HAR

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ics
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:211773 )

IMPC - ICS

vision/eye

decreased total retina thickness ( J:211773 )

IMPC - ICS

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ieg
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased red blood cell distribution width ( J:211773 )

IMPC - HMGU

decreased mean platelet volume ( J:211773 )

IMPC - HMGU

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/J
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased lean body mass ( J:211773 )

IMPC - JAX

homeostasis/metabolism

decreased circulating free fatty acids level ( J:211773 )

IMPC - JAX

decreased circulating serum albumin level ( J:211773 )

IMPC - JAX

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/MbpMmucd
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - UCD

nervous system

increased prepulse inhibition ( J:211773 )

IMPC - UCD

skeleton

increased bone mineral content ( J:211773 )

IMPC - UCD

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Rbrc
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased exploration in new environment ( J:211773 )

IMPC - RBRC

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:211773 )

IMPC - RBRC

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Ucd
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased total body fat amount ( J:211773 )

IMPC - TCP

growth/size/body

increased lean body mass ( J:211773 )

IMPC - TCP

homeostasis/metabolism

increased circulating phosphate level ( J:211773 )

IMPC - TCP

skeleton

increased bone mineral content ( J:211773 )

IMPC - TCP

Allelic Composition	Dbn1^{tm1b(KOMP)Wtsi}/Dbn1⁺
Genetic Background	C57BL/6N-Dbn1^{tm1b(KOMP)Wtsi}/Wtsi
Cell Lines	EPD0211_3_A05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dbn1^{tm1b(KOMP)Wtsi} mutation (3 available); any Dbn1 mutation (44 available)

Data Sources

IMPC Data for Dbn1

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

IMPC - WTSI

increased circulating magnesium level ( J:211773 )

IMPC - WTSI

increased circulating chloride level ( J:211773 )

IMPC - WTSI

immune system

increased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

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