Dbn1^tm1.1Lbc
Targeted Allele Detail

Summary

• Symbol: Dbn1^tm1.1Lbc
• Name: drebrin 1; targeted mutation 1.1, Gert Lubec
• MGI ID: MGI:5763775
• Synonyms: drebrin-KO
• Gene: Dbn1 Location: Chr13:55621241-55635874 bp, - strand Genetic Position: Chr13, 30.06 cM
• Alliance: Dbn1^tm1.1Lbc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:224553
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 4. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 7. Cre-mediated recombination removed exons 4 through 7 and the selection cassette. Western blot analysis confirmed the absence of protein expression in the brain. (J:224553)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dbn1 Mutation: 44 strains or lines available

References

• Original: J:224553 Jung G, et al., Drebrin depletion alters neurotransmitter receptor levels in protein complexes, dendritic spine morphogenesis and memory-related synaptic plasticity in the mouse hippocampus. J Neurochem. 2015 Jul;134(2):327-39
• All: 1 reference(s)