All Phenotypes Cdkn1a<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cdkn1a⁺
wild type
MGI:2436085

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Cdkn1a^{tm1(HBsAg)Xya}/Cdkn1a⁺	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3046834
ht2	Cdkn1a^tm2(HBx)Xya/Cdkn1a⁺	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)	MGI:3046835
ht3	Cdkn1a^tm1Tyj/Cdkn1a⁺	involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J	MGI:4420544
ht4	Cdkn1a^tm1Led/Cdkn1a⁺	involves: 129S6/SvEvTac	MGI:3760239
cx5	Cdkn1a^tm1Hpw/Cdkn1a⁺ Trp53^tm2Wahl/Trp53^tm2Wahl	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6	MGI:5285193
cx6	Cdkn1a^em1Swei/Cdkn1a⁺ Dph1^em1Swei/Dph1^em2Swei	involves: C57BL/6	MGI:7645772

Allelic Composition	Cdkn1a^{tm1(HBsAg)Xya}/Cdkn1a⁺
Genetic Background	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^{tm1(HBsAg)Xya} mutation (0 available); any Cdkn1a mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 53.3% of male mice between 15 and 24 months of age, but not in any female mice of the same age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

liver/biliary system

hepatic steatosis ( J:88078 )

• observed in some mice

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma (HCC) observed in 53.3% of male mice between 15 and 24 months of age, but not in any female mice of the same age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• moderately well-differentiated HCC were made of eosinophilic cells and compressed the neighboring non-tumorous liver parenchyma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:88078

Allelic Composition	Cdkn1a^tm2(HBx)Xya/Cdkn1a⁺
Genetic Background	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S6/SvEvTac * Black Swiss)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^tm2(HBx)Xya mutation (0 available); any Cdkn1a mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma observed in 60.0% of male mice and in 45.5% of female mice after 18 months of age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

liver/biliary system

hepatic steatosis ( J:88078 )

• observed in some mice

increased hepatocellular carcinoma incidence ( J:88078 )

• hepatocellular carcinoma observed in 60.0% of male mice and in 45.5% of female mice after 18 months of age

• no metastases were detected

• HCC was multifocal with most mice exhibiting1 to 2 highly vascularized large tumors (0.5 to 2.5 cm) and many smaller tumors distributed throughout

• HCC compressing adjacent normal hepatocytes observed after 18 months of age and typically associated with fatty liver and inflammation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hepatocellular carcinoma		DOID:684	OMIM:114550	J:88078

Allelic Composition	Cdkn1a^tm1Tyj/Cdkn1a⁺
Genetic Background	involves: 129S1/SvImJ * 129S2/SvPas * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^tm1Tyj mutation (3 available); any Cdkn1a mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased incidence of tumors by ionizing radiation induction ( J:83967 )

• irradiated mice develop more tumors per mouse, 2.2-fold more benign tumors, multiple malignant tumors per mouse, and a broader spectrum of tumors than similarly treated wild-type mice

• however, the latency to tumor development and the percent of mice bearing tumors is normal

increased malignant tumor incidence ( J:83967 )

• irradiated mice develop multiple malignant tumors per mouse unlike similarly treated wild-type mice

homeostasis/metabolism

increased incidence of tumors by ionizing radiation induction ( J:83967 )

• irradiated mice develop more tumors per mouse, 2.2-fold more benign tumors, multiple malignant tumors per mouse, and a broader spectrum of tumors than similarly treated wild-type mice

• however, the latency to tumor development and the percent of mice bearing tumors is normal

Allelic Composition	Cdkn1a^tm1Led/Cdkn1a⁺
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^tm1Led mutation (1 available); any Cdkn1a mutation (63 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal auchene hair morphology ( J:125208 )

• the proportion of awl and auchene hairs are increased relative to in wild-type mice

abnormal awl hair morphology ( J:125208 )

• the proportion of awl and auchene hairs are increased relative to in wild-type mice

decreased zigzag hair amount ( J:125208 )

• the proportion of zigzag hair is reduced relative to in wild-type mice

Allelic Composition	Cdkn1a^tm1Hpw/Cdkn1a⁺ Trp53^tm2Wahl/Trp53^tm2Wahl
Genetic Background	involves: 129S4/SvJae * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^tm1Hpw mutation (1 available); any Cdkn1a mutation (63 available)
Trp53^tm2Wahl mutation (0 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased mortality induced by ionizing radiation ( J:174375 )

• compared with irradiated Trp53^tm2Wahl homozygotes

homeostasis/metabolism

decreased mortality induced by ionizing radiation ( J:174375 )

• compared with irradiated Trp53^tm2Wahl homozygotes

Allelic Composition	Cdkn1a^em1Swei/Cdkn1a⁺ Dph1^em1Swei/Dph1^em2Swei
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn1a^em1Swei mutation (0 available); any Cdkn1a mutation (63 available)
Dph1^em1Swei mutation (0 available); any Dph1 mutation (26 available)
Dph1^em2Swei mutation (0 available); any Dph1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

craniofacial phenotype ( J:347602 )

N	• fused palatal shelves in E15.5 embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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