Analysis Tools
adipose tissue
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• age-dependent increase in body fat, but not lean mass
• however, food consumption is not increased
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• cross-sectional area of bone marrow adipocytes in the tibia proximal metaphysis is increased
• 22% of female mice show a robust increase in adipocyte volume in the tibia proximal metaphysis
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nervous system
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• aged mice (30-35 weeks) show reduced brain volume, however brain volume is normal at P10 and 8 weeks of age and cerebral volume and cell counts are normal at 8 weeks of age
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• aged mice exhibit subtle reductions in ventricular volume
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• aged mice show broad reductions in cortical thickness
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behavior/neurological
| N |
• mice show no difference in sensorimotor behavior, such as balance, walking initiation, grip strength, and motor coordination, and in intellectual disability, memory or anxiety tests, including the elevated plus maze, Morris water maze test, and probe trial
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• tactile discrimination assays show no preference for novel tactile objects and no preference for visually distinct novel objects indicating a possible broad disruption of associative learning and memory
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• mice show increased time spent freezing in contextual fear testing
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• mice show increased time spent freezing in cued fear testing
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• mice eat less chow than wild-type mice
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• tactile discrimination assays show no preference for novel tactile objects and no preference for visually distinct novel objects indicating a possible broad disruption of associative learning and memory
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• mice take longer to climb down a pole and more time to climb-up an inclined screen
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hypoactivity
(
J:321204
)
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• 100- to 200-day old mice show reduced total ambulations in open field tests
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• 100-to 200-day old mice show reduced rearing events in open field tests
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• mice exhibit reduced marble-burying
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• mice show changes in social hierarchies, winning more bouts in the tube test
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• ultrasonic vocalizations are reduced in pups that are removed from the nest
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craniofacial
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• some features of skulls are slightly larger, including the mandible and localized structures in the cranium
• however, no difference in head circumference (length and width of the neurocranial bones) is seen
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• mandible is slightly larger
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growth/size/body
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• juvenile mice (21 to 27 days of age) exhibit a small reduction lean mass
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• juvenile mice (21 to 27 days of age) exhibit a small reduction in body weight and decreased lean mass
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• obesity is exacerbated by high-fat diet feeding
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• mice show increased size at 1 year of age, however size at birth and before 100 days of age is normal
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• mice show increased weight with age, however weight at birth and before 100 days of age is normal
(J:321204)
• 30- to 36-week old mice exhibit an increase in body weight under normal chow feeding conditions
(J:348991)
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• 210-day-old mice show longer femur lengths but not humerus lengths, indicating increased height
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homeostasis/metabolism
| N |
• plasma levels of leptin, triglycerides, cholesterol, glucose, and free fatty acids are not different in fasted mice
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• obesity is exacerbated by high-fat diet feeding
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• mice over 6 months of age, but not under 6 months, show a non-significant decrease in O2 consumption and a significant decrease in CO2 production, suggesting a slight decrease in respiratory quotient
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limbs/digits/tail
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• femoral and tibial mid-diaphysis cortical bone thickness is reduced in 30- to 36-week-old mice
• however, cortical tissue mineral density, marrow volume, and total volume are unchanged and no differences in femoral trabecular bone volume per tissue volume is seen
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long femur
(
J:321204
)
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• in 210-day-old mice
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• females show a reduction in tibia marrow volume and total volume
• 22% of female mice show a robust increase in adipocyte volume in the tibia proximal metaphysis
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long tibia
(
J:348991
)
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• mice exhibit a small significant increase in tibial length at 30 to 36 weeks of age
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neoplasm
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• 6 of 80 mice develop spontaneous, fatal hematopoietic malignancies after 1 year of age, including ones classified as myelodysplastic syndrome with maturation, B-cell malignancies with extensive plasma cells in the bone marrow and spleen, one acute myeloid leukemia without differentiation and one chronic myelomonocytic leukemia-like disease
• however, very few perturbations in mature cell populations in the peripheral blood and bone marrow (B-, T-, erythroid and myeloid cells), stem populations, or progenitor populations and hematopoietic cells do not show defects following the stress of a cytotoxic challenge with doxorubicin and cytarabine
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• 1 of 80 mice developed chronic myelomonocytic leukemia-like disease
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• 1 of 80 mice developed acute myeloid leukemia without differentiation
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reproductive system
skeleton
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• cross-sectional area of bone marrow adipocytes in the tibia proximal metaphysis is increased
• 22% of female mice show a robust increase in adipocyte volume in the tibia proximal metaphysis
|
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• some features of skulls are slightly larger, including the mandible and localized structures in the cranium
• however, no difference in head circumference (length and width of the neurocranial bones) is seen
|
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• mandible is slightly larger
|
|
• femoral and tibial mid-diaphysis cortical bone thickness is reduced in 30- to 36-week-old mice
• however, cortical tissue mineral density, marrow volume, and total volume are unchanged and no differences in femoral trabecular bone volume per tissue volume is seen
|
long femur
(
J:321204
)
|
• in 210-day-old mice
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|
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• females show a reduction in tibia marrow volume and total volume
• 22% of female mice show a robust increase in adipocyte volume in the tibia proximal metaphysis
|
long tibia
(
J:348991
)
|
• mice exhibit a small significant increase in tibial length at 30 to 36 weeks of age
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• growth plates in the proximal tibias of juvenile mice are slightly thicker; increase in thickness is not specific to the resting zone, proliferating zone, or hypertrophic zone
• only a slight trend towards growth plate thickening is seen in the distal femur of juveniles
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• females show a reduction in tibia marrow volume and total volume
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Tatton-Brown-Rahman syndrome | DOID:0112339 |
OMIM:615879 |
J:321204 , J:348795 , J:348991 | |
