Analysis Tools|
Allele Symbol Allele Name Allele ID |
Cd207+ wild type MGI:2435380 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• after FITC painting (hapten challenge) to dorsal ear skin, the ear-swelling response is not different from wild-type animals (24 and 48 hours after application); this indicates that there is no alteration in Cd207-positive skin dendritic cell (DC) migration to skin-draining lymph nodes (sLN) or DC function in mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• contact hypersensitivity assessed by ear swelling is attenuated at 24 hours after hapten challenge (mice were treated with diptheria toxin to induce deletion of Cd207 postive dendritic cells)
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• following intratracheally treatment with diphtheria toxin, CD11b-CD11chi dendritic ccells are depleted in the lungs
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• following treatment with diphtheria toxin, mice exhibit a rapid and complete ablation of Langerhans cells and recovery does not occur for 4 weeks
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• following treatment with diphtheria toxin
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• following intratracheally administration of diphtheria toxin, mice exhibit increased severity of influenza infection, increased weight lose and delayed clearance compared to infected wild-type mice
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• following intratracheally treatment with diphtheria toxin, CD11b-CD11chi dendritic ccells are depleted in the lungs
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• following treatment with diphtheria toxin, mice exhibit a rapid and complete ablation of Langerhans cells and recovery does not occur for 4 weeks
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increase in number of mainly MHC II+CD11c+ dendritic cells in the liver
• however, the number of dendritic cells in the lung and total numbers of macrophages, NK cells, B cells, and T cells are unaffected and mice do not exhibit anemia or alternation of circulating blood dendritic cells numbers
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• increase in number of mainly MHC II+CD11c+ dendritic cells in the liver
• however, the number of dendritic cells in the lung and total numbers of macrophages, NK cells, B cells, and T cells are unaffected and mice do not exhibit anemia or alternation of circulating blood dendritic cells numbers
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• by 12 weeks of age, mice develop small inflammatory infiltrates mainly to the liver that progressively increase in size with age
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• by 20 weeks of age, all mice show small lesions in the lung
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• by 12 weeks of age, mice develop small inflammatory infiltrates mainly to the liver that progressively increase in size with age
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• by 20 weeks of age, all mice show small lesions in the lung
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Langerhans-cell histiocytosis | DOID:2571 |
OMIM:246400 OMIM:604856 |
J:211690 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice lack almost all CD207-positive dendritic cells (DCs) in the epidermis
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• contact hypersensitivity assessed by ear swelling is attenuated at 24 hours after hapten challenge relative to wild-type controls
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• mice lack almost all CD207-positive dendritic cells (DCs) in the epidermis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/06/2026 MGI 6.24 |
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