Cd207^{tm1(Hbegf/EGFP)Bjec}
Targeted Allele Detail

Summary

• Symbol: Cd207^{tm1(Hbegf/EGFP)Bjec}
• Name: CD207 antigen; targeted mutation 1, Bjorn E Clausen
• MGI ID: MGI:3800754
• Synonyms: Cd207^{tm1(DTR/EGFP)Bjec}, Langerin-DTR
• Gene: Cd207 Location: Chr6:83648197-83654839 bp, - strand Genetic Position: Chr6, 35.94 cM, cytoband D1-D2
• Alliance: Cd207^{tm1(Hbegf/EGFP)Bjec} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137517
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Cd207^{tm1(Hbegf/EGFP)Bjec} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  Not Specified	Hbegf

• Mutation details: A diphtpheria toxin receptor fused to EGFP followed by an frt-flanked neo cassette was inserted into exon 2. Germ line, flp-mediated recombination was used to remove the neo cassette. Treatment with diphtheria toxin ablates Langerin cells. (J:137517)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd207 Mutation: 24 strains or lines available

References

• Original: J:137517 Bennett CL, et al., Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J Cell Biol. 2005 May 23;169(4):569-76
• All: 39 reference(s)