Allele Symbol Allele Name Allele ID |
Mstn+ wild type MGI:2434600 |
||||||||||||||||||||||||
Summary |
5 genotypes
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• haploinsufficiency is found, with heterozygotes having approximately half normal levels of serum myostatin in both females and males
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• hypermuscularity is variable but always greater than found in wild-type mice
• phenotype is more distinct among males
• variable expression depends on presence/absence of at least one modifier
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
myostatin-related muscle hypertrophy | DOID:0111072 |
OMIM:614160 |
J:43299 |
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• relative to mice heterozygous for Mstntm1Sjl alone
|
• relative to mice heterozygous for Mstntm1Sjl alone
|
|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice have 17 to 19 thoracic vertebrae compared to 13 in wild-type mice
|
• mice have 7 to 9 lumbar vertebrae compared to 6 in wild-type mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 03/25/2025 MGI 6.24 |
![]() |
|