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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mstn+
wild type
MGI:2434600
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Mstntm2Sjl/Mstn+ B6.129-Mstntm2Sjl MGI:3789914
ht2
Mstntm1Sjl/Mstn+ B6N.129-Mstntm1Sjl MGI:5902425
ht3
MstnCmpt/Mstn+ either: HCI or HCR MGI:5529108
cx4
Fsttm1Zuk/Fst+
Mstntm1Sjl/Mstn+
B6.129-Mstntm1Sjl Fsttm1Zuk MGI:5319777
cx5
Gdf11tm1Sjl/Gdf11tm1Sjl
Mstntm1Sjl/Mstn+
involves: 129S1/Sv * 129X1/SvJ MGI:4438572


Genotype
MGI:3789914
ht1
Allelic
Composition
Mstntm2Sjl/Mstn+
Genetic
Background
B6.129-Mstntm2Sjl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mstntm2Sjl mutation (0 available); any Mstn mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• 14-19% increase in skeletal muscle mass




Genotype
MGI:5902425
ht2
Allelic
Composition
Mstntm1Sjl/Mstn+
Genetic
Background
B6N.129-Mstntm1Sjl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mstntm1Sjl mutation (2 available); any Mstn mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• haploinsufficiency is found, with heterozygotes having approximately half normal levels of serum myostatin in both females and males




Genotype
MGI:5529108
ht3
Allelic
Composition
MstnCmpt/Mstn+
Genetic
Background
either: HCI or HCR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MstnCmpt mutation (0 available); any Mstn mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• hypermuscularity is variable but always greater than found in wild-type mice
• phenotype is more distinct among males
• variable expression depends on presence/absence of at least one modifier

growth/size/body

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myostatin-related muscle hypertrophy DOID:0111072 OMIM:614160
J:43299




Genotype
MGI:5319777
cx4
Allelic
Composition
Fsttm1Zuk/Fst+
Mstntm1Sjl/Mstn+
Genetic
Background
B6.129-Mstntm1Sjl Fsttm1Zuk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fsttm1Zuk mutation (2 available); any Fst mutation (19 available)
Mstntm1Sjl mutation (2 available); any Mstn mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• relative to mice heterozygous for Mstntm1Sjl alone

growth/size/body
• relative to mice heterozygous for Mstntm1Sjl alone




Genotype
MGI:4438572
cx5
Allelic
Composition
Gdf11tm1Sjl/Gdf11tm1Sjl
Mstntm1Sjl/Mstn+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdf11tm1Sjl mutation (0 available); any Gdf11 mutation (12 available)
Mstntm1Sjl mutation (2 available); any Mstn mutation (35 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• mice have 17 to 19 thoracic vertebrae compared to 13 in wild-type mice
• mice have 7 to 9 lumbar vertebrae compared to 6 in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory