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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itga8+
wild type
MGI:2434418
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Itga8tm1b(KOMP)Wtsi/Itga8+ C57BL/6N-Itga8tm1b(KOMP)Wtsi/J MGI:5631232
ht2
 		Itga8tm1Lfr/Itga8+ involves: 129X1/SvJ * C57BL/6 MGI:3715483
cx3
 		Itga3tm1Jak/Itga3+
Itga5tm1Hyn/Itga5+
Itga8tm1Lfr/Itga8+ 		involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6J MGI:3583667
cx4
 		Gdnftm1Rosl/Gdnf+
Itga8tm1Lfr/Itga8+ 		involves: 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3715482
cx5
 		Itga3tm1Jak/Itga3+
Itga8tm1Lfr/Itga8+ 		involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J MGI:3583665


Genotype
MGI:5631232
ht1
Allelic
Composition		 Itga8tm1b(KOMP)Wtsi/Itga8+
Genetic
Background		 C57BL/6N-Itga8tm1b(KOMP)Wtsi/J
Cell Lines EPD0569_1_D04
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga8tm1b(KOMP)Wtsi mutation (1 available); any Itga8 mutation (74 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological

hematopoietic system

homeostasis/metabolism




Genotype
MGI:3715483
ht2
Allelic
Composition		 Itga8tm1Lfr/Itga8+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga8tm1Lfr mutation (2 available); any Itga8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:122519 )
N
• no kidney agenesis is observed




Genotype
MGI:3583667
cx3
Allelic
Composition		 Itga3tm1Jak/Itga3+
Itga5tm1Hyn/Itga5+
Itga8tm1Lfr/Itga8+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Jak mutation (0 available); any Itga3 mutation (52 available)
Itga5tm1Hyn mutation (1 available); any Itga5 mutation (45 available)
Itga8tm1Lfr mutation (2 available); any Itga8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
reduced long-term potentiation ( J:84858 )
• nearly complete elimination of long term potentiation after 60 minutes

behavior/neurological
abnormal spatial learning ( J:84858 )
• deficient in spatial memory in a Morris water maze test
• normal fear conditioning however




Genotype
MGI:3715482
cx4
Allelic
Composition		 Gdnftm1Rosl/Gdnf+
Itga8tm1Lfr/Itga8+
Genetic
Background		 involves: 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1Rosl mutation (0 available); any Gdnf mutation (18 available)
Itga8tm1Lfr mutation (2 available); any Itga8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
absent kidney ( J:122519 )
• 53% kidney agenesis incidence




Genotype
MGI:3583665
cx5
Allelic
Composition		 Itga3tm1Jak/Itga3+
Itga8tm1Lfr/Itga8+
Genetic
Background		 involves: 129S4/SvJae * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga3tm1Jak mutation (0 available); any Itga3 mutation (52 available)
Itga8tm1Lfr mutation (2 available); any Itga8 mutation (74 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
reduced long-term potentiation ( J:84858 )
• increasingly severe deficient long term potentiation response shortly after tetanus




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory