Phenotypes associated with this allele

• Allele Symbol: Alk⁺
• Allele Name: wild type
• Allele ID: MGI:2433198
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Alk^tm2.1Ics/Alk^+	B6N.129S2(Cg)-Alk^tm2.1Ics	MGI:5789378
ht2	Alk^tm2.1Ics/Alk^+	involves: 129S2/SvPas * C57BL/6	MGI:5789372
cn3	Alk^tm1.1(ALK*F1174L)Heno/Alk^+ Tg(Mpz-cre)94Imeg/0 Tg(Th-MYCN)41Waw/0	involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL	MGI:6476983

Genotype
MGI:5789378

ht1

• Allelic Composition: Alk^tm2.1Ics/Alk⁺
• Genetic Background: B6N.129S2(Cg)-Alk^tm2.1Ics

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:226655 )

♂ • the movement response to hypercapnia is disrupted

♂ • however, mice do not show differences in the Y-maze or the tail suspension tests

decreased food intake ( J:226655 )

♂ • 48% of newborn mutants have a full stomach compared to 61% of wild-type mice, indicating some reduction in milk intake

increased anxiety-related response ( J:226655 )

♂ • during the dark/light test, mice spend less time in the light side, wait longer before going for the first time in the light side and do less light/dark transitions

increased grip strength ( J:226655 )

♂ • mice show increased muscle strength when allowed to grip with all paws

decreased vertical activity ( J:226655 )

♂ • mice exhibit less rears during the dark phase

decreased locomotor activity ( J:226655 )

♂ • mice exhibit less locomotor activity during the dark phase

homeostasis/metabolism

increased circulating alkaline phosphatase level ( J:226655 )

♂ • slightly higher levels

increased circulating chloride level ( J:226655 )

♂ • slightly higher levels

vision/eye

abnormal eye morphology ( J:226655 )

♂ • 7 of 11 mice exhibit minor abnormalities of the visual system, showing a small zone of higher reflectance under one of the main blood vessels and/or a small white spot under a vein

Genotype
MGI:5789372

ht2

• Allelic Composition: Alk^tm2.1Ics/Alk⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

nervous system

abnormal sympathetic ganglion morphology ( J:228124 )

• excess of proliferation in sympathetic ganglia

abnormal stellate ganglion morphology ( J:228124 )

• increase in size of the stellate ganglia in adults and at birth

• increase in the number of neuroblasts per ganglion in the stellate ganglia at E14.5

abnormal superior cervical ganglion morphology ( J:228124 )

• increase in the number of neuroblasts per ganglion in the superior cervical ganglia at E14.5

enlarged superior cervical ganglion ( J:228124 )

• increase in size of the superior cervical ganglia in adults and at birth

Genotype
MGI:6476983

cn3

• Allelic Composition: Alk^{tm1.1(ALK*F1174L)Heno}/Alk⁺; Tg(Mpz-cre)94Imeg/0; Tg(Th-MYCN)41Waw/0
• Genetic Background: involves: 129X1/SvJ * BALB/c * C57BL/6 * SJL

mortality/aging

decreased tumor-free survival time ( J:294092 )

• mice that develop thoracic and/or abdominal tumors die by 6 months

neoplasm

increased neuroblastoma incidence ( J:294092 )

• 17 of 18 mice develop bulky thoracic and/or abdominal tumors, with tumors showing features characteristic of neuroblastoma

• 14 of 18 mice exhibit abdominal tumors

• 4 of 18 mice exhibit thoracic tumors

• 2 of 18 mice exhibit both abdominal and thoracic tumors

nervous system

increased neuroblastoma incidence ( J:294092 )

• 17 of 18 mice develop bulky thoracic and/or abdominal tumors, with tumors showing features characteristic of neuroblastoma

• 14 of 18 mice exhibit abdominal tumors

• 4 of 18 mice exhibit thoracic tumors

• 2 of 18 mice exhibit both abdominal and thoracic tumors

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuroblastoma		DOID:769		J:294092