All Phenotypes Hmga2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hmga2⁺
wild type
MGI:2432865

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Hmga2^tm1Cha/Hmga2⁺	involves: 129S7/SvEvBrd	MGI:3054550
ht2	Hmga2^pg-Tg40BCha/Hmga2⁺	involves: C57BL/6J * CBA/J	MGI:3834945
ht3	Hmga2^pg-Tg40ACha/Hmga2⁺	involves: C57BL/6J * CBA/J	MGI:3834943
ht4	Hmga2^em1Sson/Hmga2⁺	involves: C57BL/6N	MGI:7294530
cn5	Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Hmga2^tm1.1Mmw/Hmga2⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm2Tyj/Trp53⁺	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * FVB/N	MGI:6295996
cx6	Hmga2^tm1Cha/Hmga2⁺ Lep^ob/Lep^ob	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3834966

Allelic Composition	Hmga2^tm1Cha/Hmga2⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmga2^tm1Cha mutation (0 available); any Hmga2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased susceptibility to diet-induced obesity ( J:61493 )

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:61493 )

Allelic Composition	Hmga2^pg-Tg40BCha/Hmga2⁺
Genetic Background	involves: C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmga2^pg-Tg40BCha mutation (1 available); any Hmga2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

adipose tissue

decreased percent body fat/body weight ( J:21153 )

• the ratio of gonadal fat pad weight to body weight is decreased compared to in wild-type mice

Allelic Composition	Hmga2^pg-Tg40ACha/Hmga2⁺
Genetic Background	involves: C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmga2^pg-Tg40ACha mutation (0 available); any Hmga2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small adrenal glands ( J:21153 )

• 58% to 67% of wild-type

small testis ( J:21153 )

• 67% of wild-type

growth/size/body

decreased body weight ( J:21153 )

• 80% of wild-type at 10 weeks

nervous system

abnormal brain size ( J:21153 )

• despite an 80% reduction in body weight, brain weight is 97% of wild-type

reproductive system

small testis ( J:21153 )

• 67% of wild-type

Allelic Composition	Hmga2^em1Sson/Hmga2⁺
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmga2^em1Sson mutation (0 available); any Hmga2 mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:324153 )

• adult mice show a ~20% reduction in body weight relative to wild-type controls

behavior/neurological

decreased locomotor activity ( J:324153 )

• during a 30-min open field test, males - but not females - show significantly decreased velocity and total distance traveled relative to wild-type males

reproductive system

reproductive system phenotype ( J:324153 )

N	• both male and female mice are fertile

Allelic Composition	Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Hmga2^tm1.1Mmw/Hmga2⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm2Tyj/Trp53⁺
Genetic Background	involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6NCrl * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm9(CAG-tdTomato)Hze} mutation (7 available); any Gt(ROSA)26Sor mutation (1083 available)
Hmga2^tm1.1Mmw mutation (1 available); any Hmga2 mutation (12 available)
Kras^tm4Tyj mutation (11 available); any Kras mutation (69 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
Trp53^tm2Tyj mutation (2 available); any Trp53 mutation (237 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased pancreatic ductal adenocarcinoma incidence ( J:245611 )

• mice develop pancreatic ductal adenocarcinoma (PDAC)

neoplasm

increased pancreatic ductal adenocarcinoma incidence ( J:245611 )

• mice develop pancreatic ductal adenocarcinoma (PDAC)

increased metastatic potential ( J:245611 )

• GFP+ PDAC cells form tumors form more metastases than GFP- PDAC cells when transplanted into recipient mice

• the highly metastatic PDAC subpopulation is enriched for hypoxia-induced genes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:245611

Allelic Composition	Hmga2^tm1Cha/Hmga2⁺ Lep^ob/Lep^ob
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hmga2^tm1Cha mutation (0 available); any Hmga2 mutation (12 available)
Lep^ob mutation (5 available); any Lep mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:61493 )

• mice are smaller than Lep^ob homozygotes

decreased body weight ( J:61493 )

• 72% of Lep^ob homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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