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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Yy1+
wild type
MGI:2432492
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Yy1tm3.1Yshi/Yy1+ involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J MGI:5562925
ht2
 		Yy1tm1Yshi/Yy1+ involves: 129S4/SvJae * C57BL/6 MGI:2653500
cn3
 		Dicer1tm1Bdh/Dicer1+
Yy1tm2.1Yshi/Yy1+
Shhtm1(EGFP/cre)Cjt/Shh+ 		involves: 129 * 129S4/SvJae * C57BL/6 MGI:5902326


Genotype
MGI:5562925
ht1
Allelic
Composition		 Yy1tm3.1Yshi/Yy1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yy1tm3.1Yshi mutation (0 available); any Yy1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:208226 )
N
• mice exhibit normal B cell development




Genotype
MGI:2653500
ht2
Allelic
Composition		 Yy1tm1Yshi/Yy1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Yy1tm1Yshi mutation (0 available); any Yy1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
decreased embryo size ( J:57857 )
• incomplete penetrance, seen in ~25% of mixed strain heterozygotes

growth/size/body
decreased embryo size ( J:57857 )
• incomplete penetrance, seen in ~25% of mixed strain heterozygotes

nervous system
exencephaly ( J:57857 )
• incomplete penetrance, seen in ~25% of mixed strain heterozygotes




Genotype
MGI:5902326
cn3
Allelic
Composition		 Dicer1tm1Bdh/Dicer1+
Yy1tm2.1Yshi/Yy1+
Shhtm1(EGFP/cre)Cjt/Shh+
Genetic
Background		 involves: 129 * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dicer1tm1Bdh mutation (6 available); any Dicer1 mutation (96 available)
Shhtm1(EGFP/cre)Cjt mutation (2 available); any Shh mutation (48 available)
Yy1tm2.1Yshi mutation (0 available); any Yy1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:239777 )
N
• embryos do not present lung defects




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory