Phenotypes associated with this allele

• Allele Symbol: Xbp1⁺
• Allele Name: wild type
• Allele ID: MGI:2432394
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Xbp1^tm1a(EUCOMM)Wtsi/Xbp1^+	C57BL/6N-Xbp1^tm1a(EUCOMM)Wtsi/Ics	MGI:5782227
ht2	Xbp1^tm1b(EUCOMM)Wtsi/Xbp1^+	C57BL/6N-Xbp1^tm1b(EUCOMM)Wtsi/Ics	MGI:5797919
cn3	Xbp1^tm2Glm/Xbp1^+ Tg(Vil1-cre)997Gum/0	involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL	MGI:5441533

Genotype
MGI:5782227

ht1

• Allelic Composition: Xbp1^{tm1a(EUCOMM)Wtsi}/Xbp1⁺
• Genetic Background: C57BL/6N-Xbp1^{tm1a(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0038_2_B10

Data Sources

IMPC Data for Xbp1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased grip strength ( J:165965 )

IMPC - HMGU

hematopoietic system

decreased T cell number ( J:165965 )

♂

IMPC - HMGU

decreased IgG1 level ( J:165965 )

♂

IMPC - HMGU

homeostasis/metabolism

decreased circulating cholesterol level ( J:165965 )

♂

IMPC - HMGU

decreased circulating triglyceride level ( J:165965 )

IMPC - HMGU

immune system

decreased T cell number ( J:165965 )

♂

IMPC - HMGU

decreased IgG1 level ( J:165965 )

♂

IMPC - HMGU

skeleton

vertebral fusion ( J:165965 )

IMPC - ICS

abnormal bone structure ( J:165965 )

IMPC - HMGU

abnormal bone mineralization ( J:165965 )

IMPC - HMGU

Genotype
MGI:5797919

ht2

• Allelic Composition: Xbp1^{tm1b(EUCOMM)Wtsi}/Xbp1⁺
• Genetic Background: C57BL/6N-Xbp1^{tm1b(EUCOMM)Wtsi}/Ics
• Cell Lines: EPD0038_2_E10

Data Sources

IMPC Data for Xbp1

hematopoietic system

increased mean corpuscular hemoglobin ( J:211773 )

♂

IMPC - HAR

increased mean corpuscular volume ( J:211773 )

♂

IMPC - HAR

decreased red blood cell distribution width ( J:211773 )

♀

IMPC - HAR

decreased leukocyte cell number ( J:211773 )

♀

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - HAR

decreased large unstained cell number ( J:211773 )

♀

IMPC - HAR

immune system

decreased leukocyte cell number ( J:211773 )

♀

IMPC - HAR

decreased lymphocyte cell number ( J:211773 )

♀

IMPC - HAR

decreased large unstained cell number ( J:211773 )

♀

IMPC - HAR

vision/eye

persistence of hyaloid vascular system ( J:211773 )

IMPC - HAR

Genotype
MGI:5441533

cn3

• Allelic Composition: Xbp1^tm2Glm/Xbp1⁺; Tg(Vil1-cre)997Gum/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * FVB/N * SJL

digestive/alimentary system

small intestinal inflammation ( J:188627 )

• mild in 5 of 16 mice

immune system

small intestinal inflammation ( J:188627 )

• mild in 5 of 16 mice