All Phenotypes Thrb<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Thrb⁺
wild type
MGI:2432230

Summary

10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Thrb^tm1Df/Thrb⁺	either: B6.129S1-Thrb^tm1Df or (involves: 129S1/Sv * C57BL/6J)	MGI:3699105
ht2	Thrb^tm6.1Few/Thrb⁺	involves: 129 * C57BL/6	MGI:3849882
ht3	Thrb^tm5Few/Thrb⁺	involves: 129 * C57BL/6	MGI:3608673
ht4	Thrb^tm1.1Syc/Thrb⁺	involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss	MGI:3721432
ht5	Thrb^tm1.1Syc/Thrb⁺	involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss	MGI:3715607
ht6	Thrb^tm1.1Syc/Thrb⁺	involves: 129S6/SvEvTac * NIH Black Swiss	MGI:5528982
ht7	Thrb^tm2Few/Thrb⁺	involves: 129X1/SvJ * C57BL/6	MGI:3588064
cn8	Thrb^tm1Mkni/Thrb⁺ Hprt1^{tm1(TG-cre)1Sasr}/Y	involves: 129/Sv * C57BL/6	MGI:5576934
cx9	Thra^tm1Ven/Thra^tm1Ven Thrb^tm1Df/Thrb⁺	B6.129-Thra^tm1Ven Thrb^tm1Df	MGI:3698828
cx10	Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl	MGI:3606079

Allelic Composition	Thrb^tm1Df/Thrb⁺
Genetic Background	either: B6.129S1-Thrb^tm1Df or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrb^tm1Df mutation (1 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:103702 )

N	• unlike homozygotes, heterozygotes of either genetic background are resistant to audiogenic seizures

Allelic Composition	Thrb^tm6.1Few/Thrb⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrb^tm6.1Few mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:150008 )

N	• thyroid-stimulating hormone serum levels are normal

increased circulating thyroxine level ( J:150008 )

• 2-fold higher than in wild-type mice

increased circulating triiodothyronine level ( J:150008 )

• 2-fold higher than in wild-type mice

growth/size/body

decreased body weight ( J:150008 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:150008

Allelic Composition	Thrb^tm5Few/Thrb⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrb^tm5Few mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating thyroxine level ( J:100929 )

• T4 levels are increased about 2-fold compared to wild-type mice

endocrine/exocrine glands

increased thyroid gland weight ( J:100929 )

• thyroid weight is increased compared to wild-type mice but not as much as in homozygous mice

Allelic Composition	Thrb^tm1.1Syc/Thrb⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6J * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrb^tm1.1Syc mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:124153 )

N	• at 3 weeks or 4 months of age, heterozygotes display normal auditory function, with no significant differences in ABR threholds in response to click, 8-, 16- and 32-kHz pure tone stimuli relative to wild-type mice

Allelic Composition	Thrb^tm1.1Syc/Thrb⁺
Genetic Background	involves: 129S6/SvEvTac * FVB/N * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrb^tm1.1Syc mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Histology of thyroid glands of wild-type, Thrb^tm1.1Syc/Thrb⁺ and Thrb^tm1.1Syc/Thrb^tm1.1Syc mice.

endocrine/exocrine glands

abnormal thyroid follicle morphology ( J:65885 )

• increase in the size of individual follicles of the thyroid gland

enlarged thyroid gland ( J:65885 )

• thyroid gland is about 2.4-fold larger than in wild-type

abnormal pituitary gland physiology ( J:65885 )

• the increase in TSH level despite increases in thyroid hormone levels, indicate that the pituitary is resistant to the action of thyroid hormone

homeostasis/metabolism

increased circulating thyroxine level ( J:65885 )

• 2.5-fold higher circulating T4 concentration than in wild-type

increased circulating triiodothyronine level ( J:65885 )

• 2-fold increase in the circulating total T3 concentration

increased circulating thyroid-stimulating hormone level ( J:65885 )

• TSH is 2.1-fold higher than in wild-type

skeleton

short femur ( J:65885 )

• femurs are 4% shorter

short tibia ( J:65885 )

• tibias are 5% shorter

limbs/digits/tail

short femur ( J:65885 )

• femurs are 4% shorter

short tibia ( J:65885 )

• tibias are 5% shorter

nervous system

abnormal pituitary gland physiology ( J:65885 )

• the increase in TSH level despite increases in thyroid hormone levels, indicate that the pituitary is resistant to the action of thyroid hormone

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:65885

Allelic Composition	Thrb^tm1.1Syc/Thrb⁺
Genetic Background	involves: 129S6/SvEvTac * NIH Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrb^tm1.1Syc mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal habituation ( J:114325 )

• males habituate less after multiple sessions of exploratory locomotor activity

impaired learning ( J:114325 )

• males are slower to reach criterion, requiring more sessions to reach criterion of greater than 80% hits on three consecutive sessions of the vigilance task, indicating impaired leaning on a task that requires sustained attention

Allelic Composition	Thrb^tm2Few/Thrb⁺
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thrb^tm2Few mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal spatial learning ( J:77623 )

• learning deficit identified in a Morris water maze tes

nervous system

abnormal cerebellar Purkinje cell layer ( J:77623 )

• thin

abnormal Purkinje cell morphology ( J:77623 )

• reduced branching

decreased Purkinje cell number ( J:77623 )

thin cerebellar molecular layer ( J:77623 )

small cerebellum ( J:77623 )

• changes similar to those seen in congenital hypothyroidism

homeostasis/metabolism

increased thyroxine level ( J:77623 )

increased triiodothyronine level ( J:77623 )

increased circulating thyroid-stimulating hormone level ( J:77623 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
thyroid hormone resistance syndrome		DOID:11633	OMIM:188570 OMIM:274300	J:77623

Allelic Composition	Thrb^tm1Mkni/Thrb⁺ Hprt1^{tm1(TG-cre)1Sasr}/Y
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1^{tm1(TG-cre)1Sasr} mutation (0 available); any Hprt1 mutation (1280 available)
Thrb^tm1Mkni mutation (0 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased thyroid gland weight ( J:208718 )

• significantly reduced at 2 months, compared to controls

Allelic Composition	Thra^tm1Ven/Thra^tm1Ven Thrb^tm1Df/Thrb⁺
Genetic Background	B6.129-Thra^tm1Ven Thrb^tm1Df

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm1Ven mutation (1 available); any Thra mutation (39 available)
Thrb^tm1Df mutation (1 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:73382 )

N	• on a congenic C57BL/6J background, these mutant mice display normal ABR responses to click and pure tone stimuli (8, 16, and 32 kHz)

Allelic Composition	Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6NCrl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Thra^tm3Ven mutation (0 available); any Thra mutation (39 available)
Thrb^tm1Df mutation (1 available); any Thrb mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:100290 )

• male Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺ mutants exhibited 40% less body weight at 31 days of age compared with Thra⁺/Thra⁺ Thrb^tm1Df/Thrb⁺ controls

• similar results were obtained with female mice, although the growth retardation of Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺ mutants was less at 22%

abnormal postnatal growth ( J:100290 )

• the delay in eye opening was partially rescued, occurring at day 15.3 in the Thra^tm3Ven/Thra⁺ Thrb^tm1Df/Thrb⁺ mutants compared with day 18.6 in the Thra⁺/Thra⁺ Thrb^tm1Df/Thrb⁺, and day 14 in the wt mice

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