Thrb^tm5Few
Targeted Allele Detail

Summary

• Symbol: Thrb^tm5Few
• Name: thyroid hormone receptor beta; targeted mutation 5, Fredric E Wondisford
• MGI ID: MGI:3603187
• Synonyms: TR-Beta^E457A
• Gene: Thrb Location: Chr14:4431611-4809435 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
• Alliance: Thrb^tm5Few page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100929
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutations: Insertion, Single point mutation
• Mutation details: Glutamic acid codon 457 (GAA) in exon 10 was changed to alanine (GCA) (p.E457A). A self-excising ACN cassette (loxP site + testis-specific ACE promoter driven cre gene + neomycin resistance gene cassette + loxP site) was inserted into intron 9. (J:100929)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Thrb Mutation: 41 strains or lines available

References

• Original: J:100929 Ortiga-Carvalho TM, et al., Negative regulation by thyroid hormone receptor requires an intact coactivator-binding surface. J Clin Invest. 2005 Sep;115(9):2517-23
• All: 4 reference(s)