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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tgfb2+
wild type
MGI:2432213
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Tgfb2tm1Doe/Tgfb2+ involves: 129P2/OlaHsd MGI:5008270
ht2
 		Tgfb2tm1Doe/Tgfb2+ involves: 129P2/OlaHsd * Black Swiss MGI:2668214
ht3
 		Tgfb2tm1Doe/Tgfb2+ involves: 129/Sv * 129P2/OlaHsd * Black Swiss * C57BL/6J MGI:3758329
ht4
 		Tgfb2tm1Doe/Tgfb2+ STOCK Tgfb2tm1Doe/J MGI:5444484
cn5
 		Ext1tm1Yama/Ext1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tgfb2tm1Doe/Tgfb2+ 		B6.Cg-Tgfb2tm1Doe H2az2Tg(Wnt1-cre)11Rth Ext1tm1Yama MGI:4360749
cx6
 		Tgfb2tm1Doe/Tgfb2+
Tgfb3tm1Doe/Tgfb3+ 		involves: 129P2/OlaHsd MGI:5008269
cx7
 		Tgfb2tm1Doe/Tgfb2+
Tgfb3tm1Doe/Tgfb3tm1Doe 		involves: 129P2/OlaHsd MGI:5008265
cx8
 		Fbn1tm1Hcd/Fbn1+
Tgfb2tm1Doe/Tgfb2+ 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5444488
cx9
 		Cdkn2atm1(GFP)Cjs/Cdkn2atm1(GFP)Cjs
Tgfb2tm1Doe/Tgfb2+ 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3848995


Genotype
MGI:5008270
ht1
Allelic
Composition		 Tgfb2tm1Doe/Tgfb2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased enterocyte apoptosis ( J:76342 )
• mice exhibit reduced enterocyte apoptosis in the small intestine compared with wild-type mice
• however, enterocyte apoptosis in the colon is normal
abnormal small intestinal villus morphology ( J:76342 )
• villus length is increased compared to in wild-type mice

cellular
decreased enterocyte apoptosis ( J:76342 )
• mice exhibit reduced enterocyte apoptosis in the small intestine compared with wild-type mice
• however, enterocyte apoptosis in the colon is normal




Genotype
MGI:2668214
ht2
Allelic
Composition		 Tgfb2tm1Doe/Tgfb2+
Genetic
Background		 involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bulbourethral gland morphology ( J:78547 )
• adult male heterozygotes exhibit Cowper's gland hyperplasia, local atrophy, ductal transformation and cystic dilation
bulbourethral gland cyst ( J:78547 )
• heterozygores are viable and fertile; however, some male heterozygotes develop palpable cysts in the perineal/scrotal region (9 cysts in 21 males; 1-2 cysts per animal)
• young (2-4-mo-old) males have small, externally non-visible cysts
• older (>7-mo-old) males exhibit large, fluid-filled cysts located deep to the pelvic floor, dorso-laterally of the ischiocavernosus and bulbocavernosus muscles (Cowper's syringoceles), suggesting impaired epithelial-stromal interactions
• the cellular lining of the cyst wall exhibits heterogeneity of the epithelial lining ranging from single layered squamous epithelium to multilayered glandular structures covering papillary folds
• severely hyperplastic cells from the cyst wall exhibit extreme overload of polymorphic secretory material; stratified epithelium from the cyst wall is devoid of any signs of secretion
bulbourethral gland hyperplasia ( J:78547 )
• adult male heterozygotes exhibit glandular hyperplasia of Cowper's gland with thickening of the surrounding muscular capsule
• the hyperplastic glandular epithelium is multilayered with large foamy or vacuolated cells and irregular nuclear structure and position
prostate gland anterior lobe hyperplasia ( J:78547 )
• male heterozygotes exhibit coagulating gland hyperplasia
abnormal bulbourethral gland physiology ( J:78547 )
• hyperplastic Cowper's glands exhibit an ~80% reduction in apoptotic cell death relative to wild-type glands

reproductive system
abnormal bulbourethral gland morphology ( J:78547 )
• adult male heterozygotes exhibit Cowper's gland hyperplasia, local atrophy, ductal transformation and cystic dilation
bulbourethral gland cyst ( J:78547 )
• heterozygores are viable and fertile; however, some male heterozygotes develop palpable cysts in the perineal/scrotal region (9 cysts in 21 males; 1-2 cysts per animal)
• young (2-4-mo-old) males have small, externally non-visible cysts
• older (>7-mo-old) males exhibit large, fluid-filled cysts located deep to the pelvic floor, dorso-laterally of the ischiocavernosus and bulbocavernosus muscles (Cowper's syringoceles), suggesting impaired epithelial-stromal interactions
• the cellular lining of the cyst wall exhibits heterogeneity of the epithelial lining ranging from single layered squamous epithelium to multilayered glandular structures covering papillary folds
• severely hyperplastic cells from the cyst wall exhibit extreme overload of polymorphic secretory material; stratified epithelium from the cyst wall is devoid of any signs of secretion
bulbourethral gland hyperplasia ( J:78547 )
• adult male heterozygotes exhibit glandular hyperplasia of Cowper's gland with thickening of the surrounding muscular capsule
• the hyperplastic glandular epithelium is multilayered with large foamy or vacuolated cells and irregular nuclear structure and position
prostate gland anterior lobe hyperplasia ( J:78547 )
• male heterozygotes exhibit coagulating gland hyperplasia
abnormal bulbourethral gland physiology ( J:78547 )
• hyperplastic Cowper's glands exhibit an ~80% reduction in apoptotic cell death relative to wild-type glands
abnormal spermatogenesis ( J:78547 )
• male heterozygotes show a reduced yield of spermatogenesis
teratozoospermia ( J:78547 )
• male heterozygotes display malformed spermatozoa

cellular
teratozoospermia ( J:78547 )
• male heterozygotes display malformed spermatozoa

growth/size/body
bulbourethral gland cyst ( J:78547 )
• heterozygores are viable and fertile; however, some male heterozygotes develop palpable cysts in the perineal/scrotal region (9 cysts in 21 males; 1-2 cysts per animal)
• young (2-4-mo-old) males have small, externally non-visible cysts
• older (>7-mo-old) males exhibit large, fluid-filled cysts located deep to the pelvic floor, dorso-laterally of the ischiocavernosus and bulbocavernosus muscles (Cowper's syringoceles), suggesting impaired epithelial-stromal interactions
• the cellular lining of the cyst wall exhibits heterogeneity of the epithelial lining ranging from single layered squamous epithelium to multilayered glandular structures covering papillary folds
• severely hyperplastic cells from the cyst wall exhibit extreme overload of polymorphic secretory material; stratified epithelium from the cyst wall is devoid of any signs of secretion




Genotype
MGI:3758329
ht3
Allelic
Composition		 Tgfb2tm1Doe/Tgfb2+
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
decreased dopaminergic neuron number ( J:108007 )
• heterozygotes have 12% fewer dopaminergic neurons than wild-type littermates at 6 weeks of age; no further reduction is seen at 6 months of age

homeostasis/metabolism
decreased dopamine level ( J:108007 )
• in aged (6-month old) mice, dopamine levels are only 70% of wild-type levels in the striatum; at 6 months, the dihydroxyphenyacetic acid/dopamine ratio (DOPAC/dopamine) is significantly increased relative to wild-type




Genotype
MGI:5444484
ht4
Allelic
Composition		 Tgfb2tm1Doe/Tgfb2+
Genetic
Background		 STOCK Tgfb2tm1Doe/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aorta wall morphology ( J:188799 )
• elastic fiber fragmentation and greater collagen deposition within the medial compartment of the aortic wall is increased compared to wild-type mice
dilated aorta bulb ( J:188799 )
• by 8 months of age, heterozygotes show dilation of the aortic annulus and root
• however, dimensions of the more distal ascending aorta are normal
aortic aneurysm ( J:188799 )
• aortic root aneurysm

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Loeys-Dietz syndrome DOID:0050466 J:188799




Genotype
MGI:4360749
cn5
Allelic
Composition		 Ext1tm1Yama/Ext1+
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Tgfb2tm1Doe/Tgfb2+
Genetic
Background		 B6.Cg-Tgfb2tm1Doe H2az2Tg(Wnt1-cre)11Rth Ext1tm1Yama
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ext1tm1Yama mutation (0 available); any Ext1 mutation (65 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Thin cornea and iridocorneal dysgenesis in Ext1tm1Yama/Ext1+ H2az2Tg(Wnt1-cre)11Rth/0 Tgfb2tm1Doe/Tgfb2+ mice

mortality/aging
mortality/aging ( J:152572 )
N
• mice survive into adulthood

vision/eye
abnormal aqueous drainage system morphology ( J:152572 )
• mice exhibit defects in components of the aqueous drainage system
• however, the iridocorneal angle is normal
abnormal trabecular meshwork morphology ( J:152572 )
• the trabecular beam contains fewer cells than in wild-type mice
ocular hypertension ( J:152572 )
• mice exhibit ocular hypertension unlike single heterozygotes




Genotype
MGI:5008269
cx6
Allelic
Composition		 Tgfb2tm1Doe/Tgfb2+
Tgfb3tm1Doe/Tgfb3+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
Tgfb3tm1Doe mutation (1 available); any Tgfb3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
decreased enterocyte apoptosis ( J:76342 )
• mice exhibit reduced enterocyte apoptosis in the small intestine compared with wild-type mice
• however, enterocyte apoptosis in the colon is normal
abnormal small intestinal villus morphology ( J:76342 )
• villus length is increased compared to in wild-type mice

cellular
decreased enterocyte apoptosis ( J:76342 )
• mice exhibit reduced enterocyte apoptosis in the small intestine compared with wild-type mice
• however, enterocyte apoptosis in the colon is normal




Genotype
MGI:5008265
cx7
Allelic
Composition		 Tgfb2tm1Doe/Tgfb2+
Tgfb3tm1Doe/Tgfb3tm1Doe
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
Tgfb3tm1Doe mutation (1 available); any Tgfb3 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
limbs/digits/tail
limbs/digits/tail phenotype ( J:76541 )
N
• mice exhibit normal apoptosis of interdigital webbing

vision/eye
vision/eye phenotype ( J:105113 )
N
• mice exhibit normal retinal morphology




Genotype
MGI:5444488
cx8
Allelic
Composition		 Fbn1tm1Hcd/Fbn1+
Tgfb2tm1Doe/Tgfb2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm1Hcd mutation (1 available); any Fbn1 mutation (177 available)
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal aorta wall morphology ( J:188799 )
• elastic fiber fragmentation and greater collagen deposition within the medial compartment of the aortic wall is increased compared to either single heterozygote
dilated aorta bulb ( J:188799 )
• mutants show an increase in aortic root dimension at 2 and 4 months of age compared to either single heterozygote
• aortic dilatation is specific to the aortic root
aortic aneurysm ( J:188799 )
• aortic root aneurysm

growth/size/body
growth/size/body region phenotype ( J:188799 )
N
• mutants exhibit normal body size and growth

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Loeys-Dietz syndrome DOID:0050466 J:188799




Genotype
MGI:3848995
cx9
Allelic
Composition		 Cdkn2atm1(GFP)Cjs/Cdkn2atm1(GFP)Cjs
Tgfb2tm1Doe/Tgfb2+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1(GFP)Cjs mutation (0 available); any Cdkn2a mutation (59 available)
Tgfb2tm1Doe mutation (2 available); any Tgfb2 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/24/2026
MGI 6.24 		The Jackson Laboratory