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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Spp1+
wild type
MGI:2431991
Summary 20 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Spp1Ric-s/Spp1+ A/HeJ MGI:3721554
ht2
 		Spp1Ric-r/Spp1+ A/J MGI:3721545
ht3
 		Spp1Ric-r/Spp1+ AKR/J MGI:3721544
ht4
 		Spp1Ric-r/Spp1+ BALB/cJ MGI:3721547
ht5
 		Spp1tm1Blh/Spp1+ BKSW.129S6-Spp1tm1Blh MGI:4361670
ht6
 		Spp1Ric-s/Spp1+ C3H/HeJ MGI:3721556
ht7
 		Spp1Ric-s/Spp1+ C3H/HeN MGI:3721557
ht8
 		Spp1Ric-r/Spp1+ C3H/Rv MGI:3721565
ht9
 		Spp1Ric-s/Spp1+ C3H/St MGI:3721558
ht10
 		Spp1Ric-r/Spp1+ C57BL/6J MGI:3721549
ht11
 		Spp1Ric-r/Spp1+ C57L/J MGI:3721550
ht12
 		Spp1Ric-s/Spp1+ CBA/J MGI:3721559
ht13
 		Spp1Ric-s/Spp1+ DBA/1J MGI:3721560
ht14
 		Spp1Ric-s/Spp1+ DBA/2J MGI:3721561
ht15
 		Spp1tm1Blh/Spp1+ involves: 129S6/SvEvTac * Black Swiss MGI:4361698
ht16
 		Spp1Ric-s/Spp1+ SJL/J MGI:3721562
ht17
 		Spp1Ric-r/Spp1+ SWR/J MGI:3721553
cx18
 		Apoetm1Unc/Apoetm1Unc
Spp1tm1Blh/Spp1+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J MGI:4361697
cx19
 		Apoetm1Unc/Apoetm1Unc
Spp1tm1Rit/Spp1+ 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 MGI:4361864
cx20
 		Mgptm1Kry/Mgptm1Kry
Spp1tm1Blh/Spp1+ 		involves: Black Swiss * C57BL/6J MGI:3589019


Genotype
MGI:3721554
ht1
Allelic
Composition		 Spp1Ric-s/Spp1+
Genetic
Background		 A/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-s mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:5949 )
• mice are susceptible to Rickettsia tsutsugamushi infection




Genotype
MGI:3721545
ht2
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 A/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are selectively resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:3721544
ht3
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 AKR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:3721547
ht4
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 BALB/cJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:4361670
ht5
Allelic
Composition		 Spp1tm1Blh/Spp1+
Genetic
Background		 BKSW.129S6-Spp1tm1Blh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:113585 )
• the foreign body response provoked by glutaraldehyde-fixed aortic valve leaflets is diminished in quality with a four- to five-fold increase calcification of the leaflet compared to in similarly treated wild-type mice

cardiovascular system
calcified aortic valve cusp ( J:113585 )
• the foreign body response provoked by glutaraldehyde-fixed aortic valve leaflets is diminished in quality with a four- to five-fold increase calcification of the leaflet compared to in similarly treated wild-type mice




Genotype
MGI:3721556
ht6
Allelic
Composition		 Spp1Ric-s/Spp1+
Genetic
Background		 C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-s mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:5949 )
• mice are susceptible to Rickettsia tsutsugamushi infection




Genotype
MGI:3721557
ht7
Allelic
Composition		 Spp1Ric-s/Spp1+
Genetic
Background		 C3H/HeN
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-s mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:5949 )
• mice are susceptible to Rickettsia tsutsugamushi infection




Genotype
MGI:3721565
ht8
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 C3H/Rv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:7240 )
• mice do not die following Rickettsia tsutsugamushi infection

immune system
increased macrophage cell number ( J:7240 )
• following Rickettsia tsutsugamushi infection, there is an increase in Ia+ macrophages in peritoneum exudate
decreased susceptibility to bacterial infection induced morbidity/mortality ( J:7240 )
• mice do not die following Rickettsia tsutsugamushi infection

hematopoietic system
increased macrophage cell number ( J:7240 )
• following Rickettsia tsutsugamushi infection, there is an increase in Ia+ macrophages in peritoneum exudate




Genotype
MGI:3721558
ht9
Allelic
Composition		 Spp1Ric-s/Spp1+
Genetic
Background		 C3H/St
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-s mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:5949 )
• mice are susceptible to Rickettsia tsutsugamushi infection




Genotype
MGI:3721549
ht10
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:3721550
ht11
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 C57L/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:3721559
ht12
Allelic
Composition		 Spp1Ric-s/Spp1+
Genetic
Background		 CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-s mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:5949 )
• mice are susceptible to Rickettsia tsutsugamushi infection




Genotype
MGI:3721560
ht13
Allelic
Composition		 Spp1Ric-s/Spp1+
Genetic
Background		 DBA/1J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-s mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:5949 )
• mice are susceptible to Rickettsia tsutsugamushi infection




Genotype
MGI:3721561
ht14
Allelic
Composition		 Spp1Ric-s/Spp1+
Genetic
Background		 DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-s mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:5949 )
• mice are susceptible to Rickettsia tsutsugamushi infection




Genotype
MGI:4361698
ht15
Allelic
Composition		 Spp1tm1Blh/Spp1+
Genetic
Background		 involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1tm1Blh mutation (2 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal leukocyte migration ( J:86531 )
• leukocytes exhibit decreased basal and MCP-1-dependent migration compared with similarly treated wild-type cells

cellular
abnormal leukocyte migration ( J:86531 )
• leukocytes exhibit decreased basal and MCP-1-dependent migration compared with similarly treated wild-type cells

hematopoietic system
abnormal leukocyte migration ( J:86531 )
• leukocytes exhibit decreased basal and MCP-1-dependent migration compared with similarly treated wild-type cells




Genotype
MGI:3721562
ht16
Allelic
Composition		 Spp1Ric-s/Spp1+
Genetic
Background		 SJL/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-s mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to bacterial infection ( J:5949 )
• mice are susceptible to Rickettsia tsutsugamushi infection




Genotype
MGI:3721553
ht17
Allelic
Composition		 Spp1Ric-r/Spp1+
Genetic
Background		 SWR/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Spp1Ric-r mutation (0 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:5949 )
• mice are resistant to Rickettsia tsutsugamushi infection




Genotype
MGI:4361697
cx18
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Spp1tm1Blh/Spp1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac * Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (35 available); any Apoe mutation (164 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
atherosclerotic lesions ( J:86531 )
• Angiotensin II-induced atherosclerotic lesions exhibit reduced lesion area compared to in similarly treated Apoetm1Unc homozygotes




Genotype
MGI:4361864
cx19
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Spp1tm1Rit/Spp1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (35 available); any Apoe mutation (164 available)
Spp1tm1Rit mutation (6 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to atherosclerosis ( J:103051 )
• atherosclerotic lesions in female mice are 43% smaller than in Apoetm1Unc homozygotes with reduced aortic wall inflammation

homeostasis/metabolism
increased circulating cholesterol level ( J:103051 )
• total circulating cholesterol and non-HDL-cholesterol levels are increased in male mice compared to in Apoetm1Unc homozygotes
increased circulating triglyceride level ( J:103051 )
• in male mice compared to in Apoetm1Unc homozygotes




Genotype
MGI:3589019
cx20
Allelic
Composition		 Mgptm1Kry/Mgptm1Kry
Spp1tm1Blh/Spp1+
Genetic
Background		 involves: Black Swiss * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mgptm1Kry mutation (1 available); any Mgp mutation (13 available)
Spp1tm1Blh mutation (2 available); any Spp1 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:79746 )
• mice homozygous for Mgptm1Kry and heterozygous for Spp1tm1Blh start to die during weeks 3 and 4 after birth as a result of vascular rupture and subsequent internal hemorrhage

cardiovascular system




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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory