Phenotypes associated with this allele

• Allele Symbol: Pax5⁺
• Allele Name: wild type
• Allele ID: MGI:2431552
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Pax5^m2Btlr/Pax5^+	C57BL/6J-Pax5^m2Btlr	MGI:6113404
ht2	Pax5^m3Btlr/Pax5^+	C57BL/6J-Pax5^m3Btlr	MGI:6113410
ht3	Pax5^tm1b(EUCOMM)Wtsi/Pax5^+	C57BL/6N-Pax5^tm1b(EUCOMM)Wtsi/Ieg	MGI:6263103
ht4	Pax5^tm1Mbu/Pax5^+	involves: 129S2/SvPas * C57BL/6	MGI:2654625
cn5	Pax5^tm3Mbu/Pax5^+ Tcf3^tm1(PBX1)Mlc/Tcf3^+ Cd19^tm1(cre)Cgn/Cd19^+	involves: 129P2/OlaHsd * C57BL/6	MGI:5825360
cn6	Pax5^tm3Mbu/Pax5^+ Tg(Gad1-cre,-lacZ)1Mini/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5486580

Genotype
MGI:6113404

ht1

• Allelic Composition: Pax5^m2Btlr/Pax5⁺
• Genetic Background: C57BL/6J-Pax5^m2Btlr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased B-1b cell number ( J:254824 )

• in the peripheral blood

immune system

decreased B-1b cell number ( J:254824 )

• in the peripheral blood

Genotype
MGI:6113410

ht2

• Allelic Composition: Pax5^m3Btlr/Pax5⁺
• Genetic Background: C57BL/6J-Pax5^m3Btlr

hematopoietic system

decreased B cell number ( J:254825 )

• slight reduced frequencies of total, IgD+, IgM+ B cells in the peripheral blood

immune system

decreased B cell number ( J:254825 )

• slight reduced frequencies of total, IgD+, IgM+ B cells in the peripheral blood

Genotype
MGI:6263103

ht3

• Allelic Composition: Pax5^{tm1b(EUCOMM)Wtsi}/Pax5⁺
• Genetic Background: C57BL/6N-Pax5^{tm1b(EUCOMM)Wtsi}/Ieg
• Cell Lines: EPD0237_3_F11

Data Sources

IMPC Data for Pax5

behavior/neurological

hyperactivity ( J:211773 )

IMPC - HMGU

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - HMGU

hematopoietic system

increased CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

increased memory-marker CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HMGU

homeostasis/metabolism

increased circulating triglyceride level ( J:211773 )

♂

IMPC - HMGU

increased circulating amylase level ( J:211773 )

♂

IMPC - HMGU

increased circulating lipase level ( J:211773 )

♂

IMPC - HMGU

impaired glucose tolerance ( J:211773 )

IMPC - HMGU

immune system

immune system phenotype ( J:211773 )

♀

IMPC - HMGU

increased CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

increased memory-marker CD4-positive NK T cell number ( J:211773 )

♀

IMPC - HMGU

decreased leukocyte cell number ( J:211773 )

♂

IMPC - HMGU

Genotype
MGI:2654625

ht4

• Allelic Composition: Pax5^tm1Mbu/Pax5⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6

nervous system

abnormal cerebellum morphology ( J:113076 )

• culmen of cerebellum is slightly expanded anteriorly, but inferior colliculus appears normal as opposed to homozygotes

abnormal cerebellar lobule formation ( J:113076 )

• only shallow intraculminate fissure is observed compared to homozygotes

Genotype
MGI:5825360

cn5

• Allelic Composition: Pax5^tm3Mbu/Pax5⁺; Tcf3^tm1(PBX1)Mlc/Tcf3⁺; Cd19^tm1(cre)Cgn/Cd19⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased B cell acute lymphoblastic leukemia incidence ( J:226241 )

• mice exhibit increased penetrance and accelerated acute leukemia development compared to single Tcf3^tm1(PBX1)Mlc conditional mutants

hematopoietic system

decreased immature B cell number ( J:226241 )

• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3^tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation

abnormal pro-B cell morphology ( J:226241 )

• preleukemic mice show expansion of GFP+ progenitor cells of the Lin-CD19+CD43+ fractions at younger ages compared to single Tcf3^tm1(PBX1)Mlc conditional mutants, indicating accelerated preleukemic progenitor B cell expansion

arrested B cell differentiation ( J:226241 )

• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3^tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation

immune system

decreased immature B cell number ( J:226241 )

• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3^tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation

abnormal pro-B cell morphology ( J:226241 )

• preleukemic mice show expansion of GFP+ progenitor cells of the Lin-CD19+CD43+ fractions at younger ages compared to single Tcf3^tm1(PBX1)Mlc conditional mutants, indicating accelerated preleukemic progenitor B cell expansion

arrested B cell differentiation ( J:226241 )

• preleukemic mice show a greater decrease of immature B cells of the Lin-CD19+CD43- fractions compared to Tcf3^tm1(PBX1)Mlc conditional mutants, indicating a more severe block of B cell differentiation at this stage of maturation

Genotype
MGI:5486580

cn6

• Allelic Composition: Pax5^tm3Mbu/Pax5⁺; Tg(Gad1-cre,-lacZ)1Mini/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

mortality/aging

premature death ( J:195054 )

• mice die 1-2 weeks after macroscopic changes appear (ie. domed skulls); life expectancy of such mutants is 58 days; mice that do not show this phenotype survive at least 12 months and are fertile

skeleton

domed cranium ( J:195054 )

• 19% of mice show dome shaped skulls by about postnatal day 50

craniofacial

domed cranium ( J:195054 )

• 19% of mice show dome shaped skulls by about postnatal day 50

behavior/neurological

increased anxiety-related response ( J:195054 )

• mutants spend less time in the center in open-field tests, suggesting increased anxiogenic-like behavior

increased locomotor activity ( J:195054 )

• in a novel open-field test, mutants with dome-shaped heads show significantly increased locomotion (likely due to the novelty aspect), as mutants appear lethargic in the home cages

nervous system

hydrocephaly ( J:195054 )

• 19% of mice

dilated lateral ventricle ( J:195054 )

• prominent, varying mild to severe