Phenotypes associated with this allele

• Allele Symbol: Omp⁺
• Allele Name: wild type
• Allele ID: MGI:2431534
• Summary: 32 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Robo2^tm1Rilm/Robo2^tm1Rilm Or8a1b^tm4Mom/? Omp^tm1(cre)Jae/Omp^+	involves: 129 * 129P2/OlaHsd * 129S1/Sv	MGI:5449874
cn2	Ebf2^tm2(Zfp423)Reed/Ebf2^+ Omp^tm4(cre)Mom/Omp^+	involves: 129 * 129P2/OlaHsd * C57BL/10J	MGI:5461577
cn3	Ebf2^tm3(Zfp423*)Reed/Ebf2^+ Omp^tm4(cre)Mom/Omp^+	involves: 129 * 129P2/OlaHsd * C57BL/10J	MGI:5461575
cn4	Robo2^tm1Rilm/Robo2^tm1Rilm Or5d18^tm1.1Jfcl/? Omp^tm1(cre)Jae/Omp^+	involves: 129 * 129S1/Sv	MGI:5449872
cn5	Robo2^tm1Rilm/Robo2^tm1Rilm Omp^tm1(cre)Jae/Omp^+	involves: 129 * 129S1/Sv	MGI:5449871
cn6	Robo2^tm1Rilm/Robo2^tm1Rilm Or51b4^tm1.1Jfcl/? Omp^tm1(cre)Jae/Omp^+	involves: 129 * 129S1/Sv	MGI:5449875
cn7	Ebf2^tm2(Zfp423)Reed/Ebf2^+ Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd	MGI:3714638
cn8	Slc24a4^tm1.2Hazh/Slc24a4^tm1.2Hazh Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6	MGI:5306368
cn9	Gng13^tm1Liqh/Gng13^tm1Liqh Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6	MGI:5517417
cn10	Cfap69^tm1c(KOMP)Wtsi/Cfap69^tm1c(KOMP)Wtsi Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N	MGI:5912380
cn11	Ano9^em1Uoh/Ano9^em1Uoh Omp^tm4(cre)Mom/Omp^+	involves: 129P2/OlaHsd * C57BL/6	MGI:7581989
cn12	Omp^tm4(cre)Mom/Omp^+ Ric8b^tm1c(EUCOMM)Hmgu/Ric8b^tm1c(EUCOMM)Hmgu	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL	MGI:6119583
cn13	Omp^tm4(cre)Mom/Omp^+ Gucy1b2^tm3Mom Ift88^tm1Bky/Gucy1b2^tm3Mom Ift88^tm1Bky	involves: 129P2/OlaHsd * C57BL/6J	MGI:6725130
cn14	Pgrmc1^tm1.1Jjp/Pgrmc1^tm1.1Jjp Omp^tm1(cre)Jae/Omp^+	involves: 129S1/Sv	MGI:5775111
cn15	Kirrel2^tm2c(KOMP)Wtsi/Kirrel2^tm2c(KOMP)Wtsi Omp^tm1(cre)Jae/Omp^+	involves: 129S1/Sv * C57BL/6N	MGI:6287118
cx16	Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129	MGI:3723456
cx17	Or10a4^tm1Mom/Or10a4^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-APPSwInd)Dbo/0	involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J	MGI:5811881
cx18	Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-APPSwInd)Dbo/0	involves: 129 * C3H/HeJ * C57BL/6J	MGI:5811870
cx19	Or8a1^tm25Mom/Or8a1^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-APPSwInd)Dbo/0	involves: 129 * C3H/HeJ * C57BL/6J	MGI:5811882
cx20	Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129 * C57BL/6 * CBA	MGI:3723464
cx21	Or4e5^tm2Rax/Or4e5^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3723466
cx22	Or10a4^tm6Rax/Or10a4^tm6Rax Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-Kcnj2,lacZ)1Gogo/?	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3723465
cx23	Ebf2^tm2.1(Zfp423)Reed/Ebf2^+ Omp^tm1Mom/Omp^+	involves: 129S2/SvPas	MGI:3714637
cx24	Omp^tm1Mom/Omp^+ Zfp423^tm1Reed/Zfp423^tm1Reed	involves: 129S2/SvPas	MGI:3714641
cx25	Adcy3^tm1Drs/Adcy3^tm1Drs Omp^tm1Mom/Omp^+	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3714863
cx26	Bdnf^tm1Jae/Bdnf^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723444
cx27	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)1Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723454
cx28	Ngfr^tm1Jae/Ngfr^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723452
cx29	Ngfr^tm1Jae/Ngfr^tm1Jae Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S4/SvJae * C57BL/6	MGI:3723445
cx30	Bdnf^tm1(BDNF)Gogo/Bdnf^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S/SvEv	MGI:3723437
cx31	Bdnf^tm2(BDNF)Gogo/Bdnf^+ Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	involves: 129S/SvEv	MGI:3723439
cx32	Omp^tm1(tTA)Gogo/Omp^+ Tg(tetO-tetX,lacZ)2Gogo/?	Not Specified	MGI:3723455

Genotype
MGI:5449874

cn1

• Allelic Composition: Robo2^tm1Rilm/Robo2^tm1Rilm; Or8a1b^tm4Mom/?; Omp^tm1(cre)Jae/Omp⁺
• Genetic Background: involves: 129 * 129P2/OlaHsd * 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal olfactory bulb morphology ( J:173325 )

• an additional lacZ positive glomerulus is detected on the dorsolateral side of the olfactory bulb, only the glomerulus on the medial side is detected in controls

Genotype
MGI:5461577

cn2

• Allelic Composition: Ebf2^{tm2(Zfp423)Reed}/Ebf2⁺; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

nervous system

impaired neuron differentiation ( J:190934 )

• impaired olfactory sensory neuron differentiation

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

taste/olfaction

abnormal olfactory epithelium morphology ( J:190934 )

• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

cellular

impaired neuron differentiation ( J:190934 )

• impaired olfactory sensory neuron differentiation

craniofacial

abnormal olfactory epithelium morphology ( J:190934 )

• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

respiratory system

abnormal olfactory epithelium morphology ( J:190934 )

• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

growth/size/body

abnormal olfactory epithelium morphology ( J:190934 )

• the main olfactory epithelium is mostly devoid of mature olfactory sensory neurons

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of mature olfactory sensory neurons and increase in the number of immature neurons

Genotype
MGI:5461575

cn3

• Allelic Composition: Ebf2^{tm3(Zfp423*)Reed}/Ebf2⁺; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129 * 129P2/OlaHsd * C57BL/10J

nervous system

nervous system phenotype ( J:190934 )

N • development of olfactory sensory neurons is similar to controls

Genotype
MGI:5449872

cn4

• Allelic Composition: Robo2^tm1Rilm/Robo2^tm1Rilm; Or5d18^tm1.1Jfcl/?; Omp^tm1(cre)Jae/Omp⁺
• Genetic Background: involves: 129 * 129S1/Sv

nervous system

abnormal olfactory bulb morphology ( J:173325 )

• olfactory sensory neurons expressing GFP are shifted ventrally in the olfactory bulb compared to controls

• in some mice (3 of 12) a third GFP positive glomerulus is detected on the lateral side of the olfactory bulb, a third glomerulus is only seen in 1 control

Genotype
MGI:5449871

cn5

• Allelic Composition: Robo2^tm1Rilm/Robo2^tm1Rilm; Omp^tm1(cre)Jae/Omp⁺
• Genetic Background: involves: 129 * 129S1/Sv

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:173325 )

• display a reduced aversive response and decreased innate avoidance behavior to the predator odorant TMT, a component of fox feces

• however, the responses to 2MB acid, an odorant of spoiled food, are similar to controls

• mice can be conditioned to respond to TMT indicating there is not a defect in detection of this odorant

Genotype
MGI:5449875

cn6

• Allelic Composition: Robo2^tm1Rilm/Robo2^tm1Rilm; Or51b4^tm1.1Jfcl/?; Omp^tm1(cre)Jae/Omp⁺
• Genetic Background: involves: 129 * 129S1/Sv

nervous system

nervous system phenotype ( J:173325 )

N • location of glomeruli from olfactory sensory neurons expressing lacZ is similar to controls

Genotype
MGI:3714638

cn7

• Allelic Composition: Ebf2^{tm2(Zfp423)Reed}/Ebf2⁺; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd

nervous system

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

craniofacial

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

respiratory system

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

growth/size/body

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

Genotype
MGI:5306368

cn8

• Allelic Composition: Slc24a4^tm1.2Hazh/Slc24a4^tm1.2Hazh; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6

taste/olfaction

abnormal olfactory system physiology ( J:180325 )

• olfactory sensory neurons exhibit prolonged termination compared with control cells

impaired olfaction ( J:180325 )

• mice exhibit reduced ability to locate odors, as indicated by decreased body weight at weaning, compared with control mice

• mice exhibit impaired ability to find a buried pellet compared with control mice

• however, mice normally locate a visible pellet

nervous system

abnormal sensory neuron physiology ( J:180325 )

• olfactory sensory neurons exhibit prolonged termination compared with control cells

growth/size/body

decreased body weight ( J:180325 )

• at weaning likely due to impaired olfaction

Genotype
MGI:5517417

cn9

• Allelic Composition: Gng13^tm1Liqh/Gng13^tm1Liqh; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6

mortality/aging

decreased survivor rate ( J:197147 )

• although mice are grossly normal, those born into litters of 7 or more display compromised survival

taste/olfaction

abnormal olfactory system morphology ( J:197147 )

• olfactory glomerular structures and axon bundles are somewhat altered

abnormal olfactory system physiology ( J:197147 )

abnormal olfactory sensory neuron physiology ( J:197147 )

• 15 odorants tested including the pheromones 2-heptanone, DMP, and TMT

• "electro-olfactogram" response to all odorants is significantly diminished

• TEA response becomes positive rather than the typical negative

impaired olfaction ( J:197147 )

• mice deprived of food for 1 day take 518 seconds to find a buried food pellet scented with peanut butter whereas controls take 26-27 seconds

• all mice find the pellet rapidly when placed on the surface of the bedding

nervous system

abnormal olfactory sensory neuron physiology ( J:197147 )

• 15 odorants tested including the pheromones 2-heptanone, DMP, and TMT

• "electro-olfactogram" response to all odorants is significantly diminished

• TEA response becomes positive rather than the typical negative

respiratory system

abnormal olfactory sensory neuron physiology ( J:197147 )

• 15 odorants tested including the pheromones 2-heptanone, DMP, and TMT

• "electro-olfactogram" response to all odorants is significantly diminished

• TEA response becomes positive rather than the typical negative

Genotype
MGI:5912380

cn10

• Allelic Composition: Cfap69^{tm1c(KOMP)Wtsi}/Cfap69^{tm1c(KOMP)Wtsi}; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6N
• Cell Lines: EPD0713_1_E05

taste/olfaction

taste/olfaction phenotype ( J:242686 )

N • mice exhibit normal structure of the olfactory epithelium

abnormal olfactory sensory neuron physiology ( J:242686 )

• faster response kinetics and stimuli integration using amyl acetate and heptaldehyde

• neurons fire action potentials more faithfully in response to repeated stimuli compared with wild-type mice

impaired olfaction ( J:242686 )

• mice take longer to find a buried food pellet when a background of the same odor is present compared with wild-type mice

behavior/neurological

behavior/neurological phenotype ( J:242686 )

N • mice exhibit normal feeding and mating behaviors

nervous system

abnormal olfactory sensory neuron physiology ( J:242686 )

• faster response kinetics and stimuli integration using amyl acetate and heptaldehyde

• neurons fire action potentials more faithfully in response to repeated stimuli compared with wild-type mice

respiratory system

abnormal olfactory sensory neuron physiology ( J:242686 )

• faster response kinetics and stimuli integration using amyl acetate and heptaldehyde

• neurons fire action potentials more faithfully in response to repeated stimuli compared with wild-type mice

Genotype
MGI:7581989

cn11

• Allelic Composition: Ano9^em1Uoh/Ano9^em1Uoh; Omp^tm4(cre)Mom/Omp⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

abnormal olfactory behavior ( J:344977 )

• fail to show a preference for peanut butter odor

• fail to show an aversive reaction to 2-methyl butyric acid

• following reward training, fail to show preference for the trained scent, carvone

Genotype
MGI:6119583

cn12

• Allelic Composition: Omp^tm4(cre)Mom/Omp⁺; Ric8b^{tm1c(EUCOMM)Hmgu}/Ric8b^{tm1c(EUCOMM)Hmgu}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N * SJL

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

abnormal olfactory epithelium physiology ( J:247954 )

• cell death is 5X higher in olfactory epithelium than in controls

abnormal olfactory sensory neuron physiology ( J:247954 )

• olfactory neurons in vitro are unresponsive to an odorant mix

impaired olfaction ( J:247954 )

• in the buried-food-seeking test, mice take longer to locate food than controls

• in the odorant preference test, mice exhibit a reduced preference to milk and peanut butter relative to water

• mice do not exhibit avoidance behavior in response to the odorant butyric acid

mortality/aging

decreased survivor rate ( J:247954 )

• overall, 11% of homozygous pups survive rather than the expected 25%

postnatal lethality, incomplete penetrance ( J:247954 )

• some pups die immediately after birth, especially pups from a litter size greater than 6

craniofacial

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

growth/size/body

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

cellular

increased neuron apoptosis ( J:247954 )

• olfactory sensory neurons exhibit a 5 fold increase in cell death

nervous system

increased neuron apoptosis ( J:247954 )

• olfactory sensory neurons exhibit a 5 fold increase in cell death

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

abnormal olfactory bulb glomerular layer morphology ( J:247954 )

• number of glomeruli is reduced and average size of glomeruli is smaller than control

small olfactory bulb ( J:247954 )

abnormal olfactory sensory neuron physiology ( J:247954 )

• olfactory neurons in vitro are unresponsive to an odorant mix

respiratory system

abnormal olfactory sensory neuron morphology ( J:247954 )

• olfactory sensory neuron layer is thinner than control

decreased olfactory sensory neuron number ( J:247954 )

• number of OMP-positive olfactory neurons is decreased in epithelium, however, number of Olfr1507-positive neurons is not reduced

abnormal olfactory epithelium physiology ( J:247954 )

• cell death is 5X higher in olfactory epithelium than in controls

abnormal olfactory sensory neuron physiology ( J:247954 )

• olfactory neurons in vitro are unresponsive to an odorant mix

behavior/neurological

behavior/neurological phenotype ( J:247954 )

N • mice do not exhibit anxiety, depression or mobility deficits

Genotype
MGI:6725130

cn13

• Allelic Composition: Omp^tm4(cre)Mom/Omp⁺; Gucy1b2^tm3Mom Ift88^tm1Bky/Gucy1b2^tm3Mom Ift88^tm1Bky
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

behavior/neurological

abnormal response to novel odor ( J:307157 )

• with IFT88 absent from type B olfactory sensory neurons, homozygotes fail to respond to NaHS by the usual dose-dependent avoidance behavior or the increased stress-induced self-grooming that occurs that occurs in controls, but respond with normal avoidance and increased self-grooming to hypoxia

homeostasis/metabolism

abnormal homeostasis ( J:307157 )

• Type B olfactory sensory neurons of the main olfactory epithelium respond normally to hypoxia but fail to respond to NaHS

Genotype
MGI:5775111

cn14

• Allelic Composition: Pgrmc1^tm1.1Jjp/Pgrmc1^tm1.1Jjp; Omp^tm1(cre)Jae/Omp⁺
• Genetic Background: involves: 129S1/Sv

behavior/neurological

abnormal sensory capabilities/reflexes/nociception ( J:223366 )

♀ • female mice exhibit constant attraction behavior to recombinant major urinary proteins (rMUPs), in both estrus and diestrus unlike wild-type mice

nervous system

nervous system phenotype ( J:223366 )

♀N • vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4

♀N • VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus

taste/olfaction

taste/olfaction phenotype ( J:223366 )

♀N • vomeronasal sensory neurons (VSNs) from ovariectomized mice exhibit normal response to recombinant major urinary proteins (rMUPs), even in the presence of diestrous levels of P4

♀N • VSNs from diestrous-staged female mice exhibit responsiveness to rMUPs across both estrus and diestrus

Genotype
MGI:6287118

cn15

• Allelic Composition: Kirrel2^{tm2c(KOMP)Wtsi}/Kirrel2^{tm2c(KOMP)Wtsi}; Omp^tm1(cre)Jae/Omp⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6N

nervous system

abnormal olfactory bulb glomerular layer morphology ( J:272414 )

• adult mice show defects in glomeruli formation with significantly larger and fewer glomeruli in the posterior region of the accessory olfactory bulb (AOB) relative to controls

• in contrast, the anterior AOB region contains glomeruli of normal size and number

Genotype
MGI:3723456

cx16

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)1Gogo/?
• Genetic Background: involves: 129

nervous system

abnormal olfactory nerve morphology ( J:124050 , J:124299 )

• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited (J:124050)

• following doxycycline treatment, the number of terminal branches of olfactory nerves is modestly increased relative to in wild-type mice (J:124050)

• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited (J:124299)

Genotype
MGI:5811881

cx17

• Allelic Composition: Or10a4^tm1Mom/Or10a4⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J

craniofacial

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

growth/size/body

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

nervous system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

abnormal olfactory bulb layer morphology ( J:199798 )

• no obvious Olfr17+ axonal convergence is seen in the olfactory bulb

respiratory system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

taste/olfaction

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

Genotype
MGI:5811870

cx18

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * C3H/HeJ * C57BL/6J

craniofacial

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

growth/size/body

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

nervous system

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory bulb morphology ( J:199798 )

• structure of the olfactory bulb is altered

abnormal olfactory bulb glomerular layer morphology ( J:199798 )

• the glomerular layer is thinner, with a massive loss of glomeruli

• treatment with doxycycline restores the glomerular layer, although the glomerular layer appears disorganized

abnormal olfactory bulb outer nerve layer morphology ( J:199798 )

• outer nerve layer is thinner

• increase in apoptosis in the outer nerve layer

• treatment with doxycycline restores the outer nerve layer

small olfactory bulb ( J:199798 )

• reduction in size of the olfactory bulb

abnormal synaptic bouton morphology ( J:199798 )

• mice show a reduction in VGlu2 staining, indicating loss of olfactory sensory neuron axon terminals in the olfactory bulb

• treatment with doxycycline restores these axon terminals in the olfactory bulb

neurodegeneration ( J:176127 )

• neurodegeneration of olfactory sensory neurons, with most lost between 7 and 14 days of age

• treatment with doxycycline reverses neurodegeneration

abnormal olfactory sensory neuron physiology ( J:176127 )

• rapid and widespread apoptosis in mature olfactory sensory neurons

respiratory system

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory sensory neuron physiology ( J:176127 )

• rapid and widespread apoptosis in mature olfactory sensory neurons

taste/olfaction

abnormal olfactory epithelium morphology ( J:176127 )

• olfactory epithelium is thinner in 3 week old mice

• olfactory epithelium shows fewer dendritic knobs with fewer cilia

abnormal olfactory sensory neuron morphology ( J:199798 )

• axonal degeneration of olfactory sensory neurons

• treatment with doxycycline prevents axonal degeneration

decreased olfactory sensory neuron number ( J:176127 )

• mature olfactory sensory neuron population is reduced in 3 week old mice

• however, the immature sensory neuron population is normal

abnormal olfactory sensory neuron physiology ( J:176127 )

• rapid and widespread apoptosis in mature olfactory sensory neurons

impaired olfaction ( J:199798 )

• in a buried food assay, mice take a longer time to find the cookie

• in an avoidance assay in which the simple odorant isovaleric acid is added to drinking water and becomes an aversive stimulus associated with an LiCl injection, the conditioned mutants show a higher preference for the odor-water than controls, indicating decreased ability to detect the odor

• administration of doxycycline restores odor detection in both the buried food assay and at high concentration of isovaleric acid in the avoidance assay

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:199798

Genotype
MGI:5811882

cx19

• Allelic Composition: Or8a1^tm25Mom/Or8a1⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-APPSwInd)Dbo/0
• Genetic Background: involves: 129 * C3H/HeJ * C57BL/6J

craniofacial

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

growth/size/body

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

nervous system

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

respiratory system

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

taste/olfaction

decreased olfactory sensory neuron number ( J:199798 )

• Olfr151 (M71)-expressing olfactory sensory neurons are decreased in number

• treatment with doxycycline for 3 weeks increases Olfr151-expressing olfactory sensory neurons and axons are able to converge and form one or two glomeruli

Genotype
MGI:3723464

cx20

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-Kcnj2,lacZ)1Gogo/?
• Genetic Background: involves: 129 * C57BL/6 * CBA

nervous system

abnormal olfactory bulb morphology ( J:124299 )

• following doxycycline treatment, organization of the glomeruli in the dorsal part of the bulb remains disorganized, thinly innervated, necklace glomeruli are absent, and nerves that enter the bulb coalesce into a giant glomerulus-like structure

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment, the spiking activity of olfactory nerves is inhibited

• following doxycycline treatment, the entry of the sensory neuron into the olfactory bulb is delayed

Genotype
MGI:3723466

cx21

• Allelic Composition: Or4e5^tm2Rax/Or4e5⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-Kcnj2,lacZ)1Gogo/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and 75% of those that enter the olfactory bulb innervate two to three glomeruli in the ventral portion of the bulb

Genotype
MGI:3723465

cx22

• Allelic Composition: Or10a4^tm6Rax/Or10a4^tm6Rax; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-Kcnj2,lacZ)1Gogo/?
• Genetic Background: involves: 129S1/Sv * C57BL/6 * CBA

nervous system

abnormal olfactory nerve morphology ( J:124299 )

• following doxycycline treatment, at P1 and more profoundly at P21 Olfr17+ olfactory nerves are diffusely distributed and those that enter the olfactory bulb sparsely innervate an average of 16 glomeruli in the ventral portion of the bulb

Genotype
MGI:3714637

cx23

• Allelic Composition: Ebf2^{tm2.1(Zfp423)Reed}/Ebf2⁺; Omp^tm1Mom/Omp⁺
• Genetic Background: involves: 129S2/SvPas

nervous system

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

craniofacial

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

respiratory system

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

growth/size/body

abnormal olfactory sensory neuron morphology ( J:122275 )

• fewer number of mature olfactory receptor neurons

Genotype
MGI:3714641

cx24

• Allelic Composition: Omp^tm1Mom/Omp⁺; Zfp423^tm1Reed/Zfp423^tm1Reed
• Genetic Background: involves: 129S2/SvPas

nervous system

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

craniofacial

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

respiratory system

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

growth/size/body

abnormal olfactory sensory neuron morphology ( J:122275 )

• olfactory receptor neuron axons fail to innervate the dorsal caudal region of the olfactory bulb

Genotype
MGI:3714863

cx25

• Allelic Composition: Adcy3^tm1Drs/Adcy3^tm1Drs; Omp^tm1Mom/Omp⁺
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

nervous system

abnormal olfactory bulb morphology ( J:122528 )

• most glomeruli, including those in the necklace and Grueneberg, are reduced and loosely organized

• however, epithelia have normal amounts of mature olfactory sensory neurons

abnormal olfactory nerve morphology ( J:122528 )

• from P15, Omp+ mature neurons are absent from the dorsocaudal part of the olfactory bulb

Genotype
MGI:3723444

cx26

• Allelic Composition: Bdnf^tm1Jae/Bdnf⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

nervous system phenotype ( J:124050 )

N • following doxycycline treatment, terminal-arbor complexity of olfactory nerves is normal

Genotype
MGI:3723454

cx27

• Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)1Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• the positive effect of global presynaptic inactinity on the total branch length is somewhat attenuated

Genotype
MGI:3723452

cx28

• Allelic Composition: Ngfr^tm1Jae/Ngfr⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity is partially rescued (4 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice)

Genotype
MGI:3723445

cx29

• Allelic Composition: Ngfr^tm1Jae/Ngfr^tm1Jae; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S4/SvJae * C57BL/6

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity of olfactory nerves is rescued with 7 branches per axon compared to 1.96+/-0.17 in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice and 6.6+/-0.19 in wild-type mice but branching length is not restored

Genotype
MGI:3723437

cx30

• Allelic Composition: Bdnf^{tm1(BDNF)Gogo}/Bdnf⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S/SvEv

nervous system

nervous system phenotype ( J:124050 )

N • following doxycycline treatment, terminal-arbor complexity and total length of olfactory nerve axons is normal

Genotype
MGI:3723439

cx31

• Allelic Composition: Bdnf^{tm2(BDNF)Gogo}/Bdnf⁺; Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: involves: 129S/SvEv

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, terminal-arbor complexity at P6 is reduced similar to in Tg(tetO-tetX,lacZ)2Gogo Omp^tm1(tTA)Gogo mice

Genotype
MGI:3723455

cx32

• Allelic Composition: Omp^tm1(tTA)Gogo/Omp⁺; Tg(tetO-tetX,lacZ)2Gogo/?
• Genetic Background: Not Specified

nervous system

abnormal olfactory nerve morphology ( J:124050 )

• following doxycycline treatment, synaptic release in olfactory sensory neurons is inhibited

• following doxycycline treatment, P6 mice exhibit a reduction in terminal-arbor complexity (1.96+/-0.17 branches per axon arbor compared to 6.6+/-0.19 in wild-type mice) and total length (153.29+/-13.16 um compared to 231.6+/-0.19 um in wild-type mice)

• following doxycycline treatment, large axonal varicosities are increased as are signs of degeneration

• however, normal branching can be reconstituted with the application of an NMDR inhibitor (MK-801)