All Phenotypes Id2<+> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Id2⁺
wild type
MGI:2431128

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Id2^{tm2b(EUCOMM)Wtsi}/Id2⁺	C57BL/6N-Id2^{tm2b(EUCOMM)Wtsi}/Wtsi	MGI:6262666
cn2	Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2⁺ Id3^tm1Zhu/Id3^tm1Zhu Tg(Nes-cre)1Kln/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:5428947
cx3	Id2^tm1Yyk/Id2⁺ Tg(Wnt1)1Hev/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL	MGI:3773817
cx4	Id2^tm2.1Ago/Id2⁺ Id3^tm2.1Cmu/Id3⁺	involves: C57BL/6	MGI:5305688

Allelic Composition	Id2^{tm2b(EUCOMM)Wtsi}/Id2⁺
Genetic Background	C57BL/6N-Id2^{tm2b(EUCOMM)Wtsi}/Wtsi
Cell Lines	EPD0977_1_G04

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2^{tm2b(EUCOMM)Wtsi} mutation (1 available); any Id2 mutation (19 available)

Data Sources

IMPC Data for Id2

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating creatinine level ( J:211773 )

IMPC - WTSI

increased blood urea nitrogen level ( J:211773 )

IMPC - WTSI

Allelic Composition	Id1^tm3Bene/Id1^tm3Bene Id2^tm1Xdz/Id2⁺ Id3^tm1Zhu/Id3^tm1Zhu Tg(Nes-cre)1Kln/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id1^tm3Bene mutation (0 available); any Id1 mutation (10 available)
Id2^tm1Xdz mutation (0 available); any Id2 mutation (19 available)
Id3^tm1Zhu mutation (1 available); any Id3 mutation (14 available)
Tg(Nes-cre)1Kln mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:185426 )

N	• neural stem cells exhibit normal self-renewal and proliferation

Allelic Composition	Id2^tm1Yyk/Id2⁺ Tg(Wnt1)1Hev/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2^tm1Yyk mutation (0 available); any Id2 mutation (19 available)
Tg(Wnt1)1Hev mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal branching of the mammary ductal tree ( J:96305 )

• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice

mammary gland hyperplasia ( J:96305 )

• mammary glands of virgin females have extensive, dense hyperplasia

neoplasm

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice

integument

abnormal branching of the mammary ductal tree ( J:96305 )

• mammary glands of virgin females have excessive ductal side branching resembling that of pregnant wild-type mice

increased mammary gland tumor incidence ( J:96305 )

• develop mammary tumors at a similar rate to that seen in single Tg(Wnt1)1Hev mice

mammary gland hyperplasia ( J:96305 )

• mammary glands of virgin females have extensive, dense hyperplasia

Allelic Composition	Id2^tm2.1Ago/Id2⁺ Id3^tm2.1Cmu/Id3⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id2^tm2.1Ago mutation (0 available); any Id2 mutation (19 available)
Id3^tm2.1Cmu mutation (0 available); any Id3 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:179006 )

N	• CD8+ T cells exhibit normal responses

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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