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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gnai2+
wild type
MGI:2430740
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gnai2tm1.1Rneu/Gnai2+ B6.129S1-Gnai2tm1.1Rneu MGI:5508326
cn2
 		Gnai2tm2.1Lbi/Gnai2+
Gnai3tm1Lbi/Gnai3tm1Lbi
Sox9tm3(cre)Crm/Sox9+ 		involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6 MGI:5471659
cx3
 		Gnai2tm1Lbi/Gnai2+
Tg(WTbeta2)4Wjk/0 		B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk MGI:3799103
cx4
 		Gnai2tm1Lbi/Gnai2+
Gnai3tm1Lbi/Gnai3tm1Lbi 		involves: 129S/SvEv * 129S7/SvEvBrd MGI:5471656


Genotype
MGI:5508326
ht1
Allelic
Composition		 Gnai2tm1.1Rneu/Gnai2+
Genetic
Background		 B6.129S1-Gnai2tm1.1Rneu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm1.1Rneu mutation (1 available); any Gnai2 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:197965 )
N
• mice exhibit normal epinephrine-induced reduction in burst frequency of induced epileptiform activity




Genotype
MGI:5471659
cn2
Allelic
Composition		 Gnai2tm2.1Lbi/Gnai2+
Gnai3tm1Lbi/Gnai3tm1Lbi
Sox9tm3(cre)Crm/Sox9+
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm2.1Lbi mutation (0 available); any Gnai2 mutation (52 available)
Gnai3tm1Lbi mutation (1 available); any Gnai3 mutation (30 available)
Sox9tm3(cre)Crm mutation (1 available); any Sox9 mutation (33 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
rib fusion ( J:193170 )
• rib fusions are more severe compared to mice homozygous for Gnai3tm1Lbi alone




Genotype
MGI:3799103
cx3
Allelic
Composition		 Gnai2tm1Lbi/Gnai2+
Tg(WTbeta2)4Wjk/0
Genetic
Background		 B6.Cg-Gnai2tm1Lbi Tg(WTbeta2)4Wjk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm1Lbi mutation (1 available); any Gnai2 mutation (52 available)
Tg(WTbeta2)4Wjk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:125581 )
• mean survival time is 223 days compared to over 600 for control mice and most mice die by 1 year of age

behavior/neurological
fatigue ( J:125581 )
• fatigue occurs in mice with age

cardiovascular system
increased heart weight ( J:125581 )
• the heart to body weight ratio is about twice that of control mice at 7 months of age
dilated heart ( J:125581 )
• heart appears dilated at necropsy

homeostasis/metabolism
cyanosis ( J:125581 )
• occurs in mucosal membranes with age
pulmonary edema ( J:125581 )
• often found at necropsy
ascites ( J:125581 )
• often found at necropsy

liver/biliary system
abnormal liver morphology ( J:125581 )
• liver congestion is often found at necropsy

respiratory system
pulmonary edema ( J:125581 )
• often found at necropsy
respiratory distress ( J:125581 )
• occurs in mice with age

growth/size/body
increased heart weight ( J:125581 )
• the heart to body weight ratio is about twice that of control mice at 7 months of age




Genotype
MGI:5471656
cx4
Allelic
Composition		 Gnai2tm1Lbi/Gnai2+
Gnai3tm1Lbi/Gnai3tm1Lbi
Genetic
Background		 involves: 129S/SvEv * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnai2tm1Lbi mutation (1 available); any Gnai2 mutation (52 available)
Gnai3tm1Lbi mutation (1 available); any Gnai3 mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Rib and sternum defects in mice with mutations of Gnai1, Gnai2, and/or Gnai3

skeleton
abnormal sternocostal joint morphology ( J:193170 )
• one mouse has the eighth rib ectopically attached to the sternum
rib fusion ( J:193170 )
• rib fusions are similar in severity to mice homozygous for Gnai3tm1Lbi and Gnai1tm1Drs




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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory