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| Caption | Rib and sternum defects in mice with mutations of Gnai genes. The images show the sternum with true ribs attached. False ribs that are not involved in any fusions have been removed. (A) Gnai3tm1Lbi/Gnai3+ (Gnai3+/-) 19-week-old, showing normal morphology of sternum and true ribs. (B) Gnai3tm1Lbi/Gnai3tm1Lbi (Gnai3-/-) 19-week-old, with fusions of the cartilaginous portion of four rib pairs. The fusions involve true ribs only. Although there is the normal number of symmetric contacts of ribs and sternum, the sternum itself is distorted. (C) Gnai3tm1Lbi/Gnai3tm1Lbi Gnai1tm1Drs/Gnai1+ (Gnai3-/- Gnai1+/-) 22-week-old, with fusion of nine rib pairs. On the right side, the first false rib is fused to the seventh true rib (blue arrowhead). (D) Gnai3tm1Lbi/Gnai3tm1Lbi Gnai1tm1Drs/Gnai1tm1Drs (Gnai3-/- Gnai1-/-) 41-week-old, with fusions involving all but one of the true ribs and one false rib (blue arrowhead). Rib-sternum contacts are asymmetric (black arrowhead), and the second and third sternebrae are fused (red arrowhead). (E) Gnai3tm1Lbi/Gnai3tm1Lbi Gnai2tm1Lbi/Gnai2+ (Gnai3-/- Gnai2+/-) 4-week-old, with fusions of ten rib pairs, including fusion of one false rib (blue arrowhead). The eighth rib on the right side is connected to the sternum (gray arrowhead). (F) Gnai3tm1Lbi/Gnai3tm1Lbi Gnai2tm1Lbi/Gnai2tm1Lbi (Gnai3-/- Gnai2-/-) 5-week-old, with an eighth rib connected to the sternum (gray arrowhead) but no rib fusions. | ||||||||||||
| Copyright | This image is from Plummer NW, Proc Natl Acad Sci U S A 2012 Dec 26;109(52):21366-71. Copyright 2012 National Academy of Sciences, U.S.A. J:193170 | ||||||||||||
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Associated Alleles |
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Associated Genotypes |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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