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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Creb1+
wild type
MGI:2430290
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Creb1tm3Gsc/Creb1+
Lrp5tm1Kry/Lrp5+
Tg(Col1a1-cre)1Kry/0 		involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB MGI:3837412
cn2
 		Creb1tm3Gsc/Creb1+
Htr1btm1Rhn/Htr1btm1Rhn
Tg(Col1a1-cre)1Kry/0 		involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N MGI:3837414
cn3
 		Creb1tm3Gsc/Creb1+
Gprc6atm1.1Kry/Gprc6a+
Tg(Cyp17a1-icre)AJako/0 		involves: 129P2/OlaHsd * C57BL/6 * SJL MGI:4949156
cx4
 		Atf1tm1Gsc/Atf1+
Creb1tm2Gsc/Creb1+ 		involves: 129/Sv * 129P2/SvPas * C57BL/6 MGI:3047273
cx5
 		Atf1tm1Gsc/Atf1tm1Gsc
Creb1tm2Gsc/Creb1+ 		involves: 129/Sv * 129P2/SvPas * C57BL/6 MGI:3047274


Genotype
MGI:3837412
cn1
Allelic
Composition		 Creb1tm3Gsc/Creb1+
Lrp5tm1Kry/Lrp5+
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1tm3Gsc mutation (2 available); any Creb1 mutation (59 available)
Lrp5tm1Kry mutation (0 available); any Lrp5 mutation (83 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
decreased bone mass ( J:146078 )
• phenotype is indistinguishable from mice homozygous null for Lrp5
decreased bone ossification ( J:146078 )
• decreased bone formation




Genotype
MGI:3837414
cn2
Allelic
Composition		 Creb1tm3Gsc/Creb1+
Htr1btm1Rhn/Htr1btm1Rhn
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1tm3Gsc mutation (2 available); any Creb1 mutation (59 available)
Htr1btm1Rhn mutation (3 available); any Htr1b mutation (26 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:146078 )
N
• loss of expression of 1 copy of Creb1 in osteoblasts rescues the bone phenotype seen in Htrb1 null mice




Genotype
MGI:4949156
cn3
Allelic
Composition		 Creb1tm3Gsc/Creb1+
Gprc6atm1.1Kry/Gprc6a+
Tg(Cyp17a1-icre)AJako/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Creb1tm3Gsc mutation (2 available); any Creb1 mutation (59 available)
Gprc6atm1.1Kry mutation (1 available); any Gprc6a mutation (65 available)
Tg(Cyp17a1-icre)AJako mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

homeostasis/metabolism

endocrine/exocrine glands

cellular




Genotype
MGI:3047273
cx4
Allelic
Composition		 Atf1tm1Gsc/Atf1+
Creb1tm2Gsc/Creb1+
Genetic
Background		 involves: 129/Sv * 129P2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf1tm1Gsc mutation (1 available); any Atf1 mutation (211 available)
Creb1tm2Gsc mutation (1 available); any Creb1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:74982 )
• mice did not exhibit any abnormalities




Genotype
MGI:3047274
cx5
Allelic
Composition		 Atf1tm1Gsc/Atf1tm1Gsc
Creb1tm2Gsc/Creb1+
Genetic
Background		 involves: 129/Sv * 129P2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf1tm1Gsc mutation (1 available); any Atf1 mutation (211 available)
Creb1tm2Gsc mutation (1 available); any Creb1 mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:74982 )
• no phenotypic or histological abnormalities were detected




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/20/2026
MGI 6.24 		The Jackson Laboratory