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Targeted Allele Detail
Symbol: Creb1tm2Gsc
Name: cAMP responsive element binding protein 1; targeted mutation 2, Gunther Schutz
MGI ID: MGI:2181382
Synonyms: CREB -
Gene: Creb1  Location: Chr1:64571963-64643707 bp, + strand  Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
Alliance: Creb1tm2Gsc page
Germline Transmission:  Earliest citation of germline transmission: J:47431
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA promoterless neomycin resistance gene was inserted in frame into exon 10, and all of intron 10 and part of exon 11 were deleted. The deleted sequences encode part of the DNA binding domain and the leucine zipper domain. RT-PCR analysis on total brain RNA demonstrated that no transcripts containing the 3' end were detectable; however, a fusion transcript containing the lacZ sequences is detected. (J:47431)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 39 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Creb1 Mutation:  59 strains or lines available
Original:  J:47431 Rudolph D, et al., Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4481-6
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.24
The Jackson Laboratory