Phenotypes associated with this allele

• Allele Symbol: Creb1^tm2Gsc
• Allele Name: targeted mutation 2, Gunther Schutz
• Allele ID: MGI:2181382
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Atf1^tm1Gsc/Atf1^tm1Gsc Creb1^tm2Gsc/Creb1^tm2Gsc	involves: 129/Sv * 129P2/SvPas * C57BL/6	MGI:2655603
cx2	Atf1^tm1Gsc/Atf1^+ Creb1^tm2Gsc/Creb1^tm2Gsc	involves: 129/Sv * 129P2/SvPas * C57BL/6	MGI:2655606
cx3	Atf1^tm1Gsc/Atf1^+ Creb1^tm2Gsc/Creb1^+	involves: 129/Sv * 129P2/SvPas * C57BL/6	MGI:3047273
cx4	Atf1^tm1Gsc/Atf1^tm1Gsc Creb1^tm2Gsc/Creb1^+	involves: 129/Sv * 129P2/SvPas * C57BL/6	MGI:3047274

Genotype
MGI:2655603

cx1

• Allelic Composition: Atf1^tm1Gsc/Atf1^tm1Gsc; Creb1^tm2Gsc/Creb1^tm2Gsc
• Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality before implantation, complete penetrance ( J:74982 )

• embryos die before implantation

cellular

abnormal apoptosis ( J:74982 )

• apoptosis was detected in most blastomere cells

embryo

failure of blastocyst to hatch from the zona pellucida ( J:74982 )

• these embryos did not develop to the blastocyst stage and did not hatch from the zona pellucida

abnormal blastocyst morphology ( J:74982 )

• preimplantation embryos had a morula appearance with no blastocoel or ICM seen

absent blastocoele ( J:74982 )

absent inner cell mass ( J:74982 )

Genotype
MGI:2655606

cx2

• Allelic Composition: Atf1^tm1Gsc/Atf1⁺; Creb1^tm2Gsc/Creb1^tm2Gsc
• Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

mortality/aging

embryonic lethality, complete penetrance ( J:74982 )

• embryos die due to massive apoptosis

cellular

abnormal apoptosis ( J:74982 )

• apoptosis was detected in most cells present at E7.5

embryo

abnormal germ layer development ( J:74982 )

• at E7.5, embryos lack differentiated germ cell layers; at E9.5, some differentiated cells were seen, but no organized cell layers were apparent

delayed blastocyst hatching from the zona pellucida ( J:74982 )

• these embryos exhibited delayed hatching from the zona pellucida

absent egg cylinders ( J:74982 )

• an accumulation of cells at the distal end of conceptus was noted

abnormal blastocyst morphology ( J:74982 )

• preimplantation embryos had a morula appearance with no blastocoel or ICM seen

• however, the trophoblast forms normally

absent blastocoele ( J:74982 )

absent inner cell mass ( J:74982 )

absent allantois ( J:74982 )

absent amnion ( J:74982 )

Genotype
MGI:3047273

cx3

• Allelic Composition: Atf1^tm1Gsc/Atf1⁺; Creb1^tm2Gsc/Creb1⁺
• Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:74982 )

• mice did not exhibit any abnormalities

Genotype
MGI:3047274

cx4

• Allelic Composition: Atf1^tm1Gsc/Atf1^tm1Gsc; Creb1^tm2Gsc/Creb1⁺
• Genetic Background: involves: 129/Sv * 129P2/SvPas * C57BL/6

normal phenotype

no abnormal phenotype detected ( J:74982 )

• no phenotypic or histological abnormalities were detected