All Phenotypes Cd9<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd9⁺
wild type
MGI:2430276

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd9^{tm1c(EUCOMM)Hmgu}/Cd9⁺ Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm1Brn/Trp53⁺	involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N	MGI:6377664
cn2	Cd9^{tm1c(EUCOMM)Hmgu}/Cd9⁺ Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm1Brn/Trp53^tm1Brn	involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N	MGI:6377665
cn3	Cd9^{tm1c(EUCOMM)Hmgu}/Cd9⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm1Brn/Trp53⁺	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6N * FVB/N	MGI:6377667

Allelic Composition	Cd9^{tm1c(EUCOMM)Hmgu}/Cd9⁺ Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm1Brn/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd9^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Cd9 mutation (101 available)
Gt(ROSA)26Sor^tm1(EYFP)Cos mutation (23 available); any Gt(ROSA)26Sor mutation (1095 available)
Kras^tm4Tyj mutation (12 available); any Kras mutation (88 available)
Tg(Pdx1-cre)6Tuv mutation (4 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:280854 )

• not as severe as in mice wild-type for Cd9 or homozygous for a conditional allele

neoplasm

increased pancreatic intraepithelial neoplasia incidence ( J:280854 )

• at 8 weeks, not as severe as in mice wild-type for Cd9 or homozygous for a conditional allele

• increased tumor weight compared to in mice homozygous for a conditional allele

decreased tumor growth/size ( J:280854 )

• compared to in mice homozygous for a conditional allele

endocrine/exocrine glands

increased pancreatic intraepithelial neoplasia incidence ( J:280854 )

• at 8 weeks, not as severe as in mice wild-type for Cd9 or homozygous for a conditional allele

• increased tumor weight compared to in mice homozygous for a conditional allele

Allelic Composition	Cd9^{tm1c(EUCOMM)Hmgu}/Cd9⁺ Gt(ROSA)26Sor^tm1(EYFP)Cos/Gt(ROSA)26Sor⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * 129X1/SvJ * C57BL/6N * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:280854 )

• not as severe as in mice wild-type for Cd9 or homozygous for a conditional allele

Allelic Composition	Cd9^{tm1c(EUCOMM)Hmgu}/Cd9⁺ Kras^tm4Tyj/Kras⁺ Tg(Pdx1-cre)6Tuv/0 Trp53^tm1Brn/Trp53⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6N * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd9^{tm1c(EUCOMM)Hmgu} mutation (0 available); any Cd9 mutation (101 available)
Kras^tm4Tyj mutation (12 available); any Kras mutation (88 available)
Tg(Pdx1-cre)6Tuv mutation (4 available)
Trp53^tm1Brn mutation (21 available); any Trp53 mutation (249 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased glutamic acid level ( J:280854 )

• reduced glutamate uptake and intracellular levels in organoids derived from tumor initiating cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24