All Phenotypes Bmp2<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bmp2⁺
wild type
MGI:2430089

Summary

11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Bmp2^{tm1(KOMP)Vlcg}/Bmp2⁺	involves: C57BL/6NTac	MGI:5912401
cn2	Bmp2^tm1Jfm/Bmp2⁺ Bmp4^tm1Jfm/Bmp4^tm1Jfm Bmp7^tm1Jfm/Bmp7^tm1Jfm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	MGI:5312874
cn3	Bmp2^tm1Jfm/Bmp2⁺ Bmp4^tm1Jfm/Bmp4^tm1Jfm Bmp7^tm1Jfm/Bmp7⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	MGI:5312871
cn4	Bmp2^tm1Jfm/Bmp2⁺ Bmp4^tm1Jfm/Bmp4⁺ Bmp7^tm1Jfm/Bmp7^tm1Jfm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	MGI:5312869
cn5	Bmp2^tm1Jfm/Bmp2⁺ Bmp4^tm1Jfm/Bmp4^tm1Jfm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J	MGI:5312866
cn6	Bmp2^tm1Cjt/Bmp2⁺ Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:3700040
cn7	Bmp2^tm1Cjt/Bmp2⁺ Bmp4^tm1Jfm/Bmp4⁺ Tg(Prrx1-cre)1Cjt/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:3700046
cn8	Bmp2^tm1Cjt/Bmp2⁺ Bmp7^tm1Rob/Bmp7⁺ Tg(Prrx1-cre)1Cjt/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3700045
cn9	Bmp2^tm1Cjt/Bmp2⁺ Bmp7^tm1Rob/Bmp7^tm1Rob Tg(Prrx1-cre)1Cjt/0	involves: 129S/SvEv * C57BL/6 * SJL	MGI:3700044
cx10	Bmp2^tm1Brd/Bmp2⁺ Tbx1^tm1Pa/Tbx1⁺	involves: 129/Sv * C57BL/6	MGI:3611300
cx11	Bmp2^tm1Brd/Bmp2⁺ Bmp7^tm1Kry/Bmp7⁺	Not Specified	MGI:3047104

Allelic Composition	Bmp2^{tm1(KOMP)Vlcg}/Bmp2⁺
Genetic Background	involves: C57BL/6NTac
Cell Lines	12406A-H3

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^{tm1(KOMP)Vlcg} mutation (1 available); any Bmp2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body length ( J:258535 )

• body is shorter

• however, no differences in femur or tibia length are seen

skeleton

decreased rib number ( J:258535 )

• 10 of 13 mice have 12 pairs of ribs and are missing the 13th rib pair at the thoracic vertebra 13

• 3 of 13 mice have 12.5 pairs of ribs and are missing one rib unilaterally

decreased bone mineral content ( J:258535 )

• decrease in bone mineral content

• however, femoral bones do not show differences in maximum load, yield load, work to failure, or stiffness

decreased bone volume ( J:258535 )

Allelic Composition	Bmp2^tm1Jfm/Bmp2⁺ Bmp4^tm1Jfm/Bmp4^tm1Jfm Bmp7^tm1Jfm/Bmp7^tm1Jfm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1Jfm mutation (1 available); any Bmp2 mutation (25 available)
Bmp4^tm1Jfm mutation (1 available); any Bmp4 mutation (21 available)
Bmp7^tm1Jfm mutation (0 available); any Bmp7 mutation (35 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

small interparietal bone ( J:181229 )

small temporal bone squamous part ( J:181229 )

• decreased size

small nasal bone ( J:181229 )

small zygomatic bone ( J:181229 )

cleft palate ( J:181229 )

hearing/vestibular/ear

abnormal tympanic ring morphology ( J:181229 )

• missing pieces

digestive/alimentary system

cleft palate ( J:181229 )

skeleton

small interparietal bone ( J:181229 )

small temporal bone squamous part ( J:181229 )

• decreased size

small nasal bone ( J:181229 )

small zygomatic bone ( J:181229 )

growth/size/body

small nasal bone ( J:181229 )

cleft palate ( J:181229 )

respiratory system

small nasal bone ( J:181229 )

Allelic Composition	Bmp2^tm1Jfm/Bmp2⁺ Bmp4^tm1Jfm/Bmp4^tm1Jfm Bmp7^tm1Jfm/Bmp7⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

small alisphenoid bone ( J:181229 )

small temporal bone squamous part ( J:181229 )

• decreased size

small nasal bone ( J:181229 )

small zygomatic bone ( J:181229 )

cleft palate ( J:181229 )

hearing/vestibular/ear

decreased tympanic ring size ( J:181229 )

digestive/alimentary system

cleft palate ( J:181229 )

skeleton

small alisphenoid bone ( J:181229 )

small temporal bone squamous part ( J:181229 )

• decreased size

small nasal bone ( J:181229 )

small zygomatic bone ( J:181229 )

growth/size/body

small nasal bone ( J:181229 )

cleft palate ( J:181229 )

respiratory system

small nasal bone ( J:181229 )

Allelic Composition	Bmp2^tm1Jfm/Bmp2⁺ Bmp4^tm1Jfm/Bmp4⁺ Bmp7^tm1Jfm/Bmp7^tm1Jfm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

absent alisphenoid bone ( J:181229 )

small temporal bone squamous part ( J:181229 )

• decreased size

cleft palate ( J:181229 )

hearing/vestibular/ear

decreased tympanic ring size ( J:181229 )

digestive/alimentary system

cleft palate ( J:181229 )

skeleton

absent alisphenoid bone ( J:181229 )

small temporal bone squamous part ( J:181229 )

• decreased size

growth/size/body

cleft palate ( J:181229 )

Allelic Composition	Bmp2^tm1Jfm/Bmp2⁺ Bmp4^tm1Jfm/Bmp4^tm1Jfm H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1Jfm mutation (1 available); any Bmp2 mutation (25 available)
Bmp4^tm1Jfm mutation (1 available); any Bmp4 mutation (21 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

small interparietal bone ( J:181229 )

skeleton

small interparietal bone ( J:181229 )

Allelic Composition	Bmp2^tm1Cjt/Bmp2⁺ Bmp4^tm1Jfm/Bmp4^tm1Jfm Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1Cjt mutation (0 available); any Bmp2 mutation (25 available)
Bmp4^tm1Jfm mutation (1 available); any Bmp4 mutation (21 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Mice deficient singly or in various combinations of Bmp2, Bmp4 and Bmp7 display limb defects

limbs/digits/tail

polydactyly ( J:118257 )

• mice exhibit variable penetrance pre- and postaxial syndactyly

Allelic Composition	Bmp2^tm1Cjt/Bmp2⁺ Bmp4^tm1Jfm/Bmp4⁺ Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:118257 )

• mutants show no defects in limb patterning and skeletogenesis

Allelic Composition	Bmp2^tm1Cjt/Bmp2⁺ Bmp7^tm1Rob/Bmp7⁺ Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1Cjt mutation (0 available); any Bmp2 mutation (25 available)
Bmp7^tm1Rob mutation (2 available); any Bmp7 mutation (35 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:118257 )

• mutants are completely like wild-type in skeletal pattern and differentiation

Allelic Composition	Bmp2^tm1Cjt/Bmp2⁺ Bmp7^tm1Rob/Bmp7^tm1Rob Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: 129S/SvEv * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:118257 )

• mutants are completely like wild-type in skeletal pattern and differentiation

Allelic Composition	Bmp2^tm1Brd/Bmp2⁺ Tbx1^tm1Pa/Tbx1⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1Brd mutation (0 available); any Bmp2 mutation (25 available)
Tbx1^tm1Pa mutation (2 available); any Tbx1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal pharyngeal arch artery morphology ( J:80764 )

• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1^tm1Pa (27% vs 25%, respectively)

• notably, pharyngeal glands appear unaffected in both groups of mice

craniofacial

abnormal pharyngeal arch artery morphology ( J:80764 )

• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1^tm1Pa (27% vs 25%, respectively)

• notably, pharyngeal glands appear unaffected in both groups of mice

embryo

abnormal pharyngeal arch artery morphology ( J:80764 )

• double heterozygous newborns show malformations in the aortic arch-derived arterial tree at a frequency similar to that observed in mice heterozygous for Tbx1^tm1Pa (27% vs 25%, respectively)

• notably, pharyngeal glands appear unaffected in both groups of mice

Allelic Composition	Bmp2^tm1Brd/Bmp2⁺ Bmp7^tm1Kry/Bmp7⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmp2^tm1Brd mutation (0 available); any Bmp2 mutation (25 available)
Bmp7^tm1Kry mutation (1 available); any Bmp7 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:48538 )

N	• doubly heterozygous pups have a normal skeleton and display no rib cage abnormalities or limb defects

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24