All Phenotypes Igh<tm2Cgn> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh^tm2Cgn
targeted mutation 2, University of Cologne
MGI:2388486

Summary

15 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igh^tm2Cgn/Igh⁺	involves: 129P2/OlaHsd * BALB/c * C57BL/Ka	MGI:3687253
ht2	Igh^tm2Cgn/Igh⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3830848
ht3	Igh^tm2Cgn/Igh^tm4.1Fwa	involves: 129P2/OlaHsd * 129S6/SvEvTac	MGI:5295455
ht4	Igh^tm2Cgn/Igh^tm3Cgn	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/Ka	MGI:3687257
ht5	Igh^tm1Cgn/Igh^tm2Cgn	involves: 129P2/OlaHsd * BALB/c * C57BL/Ka	MGI:3687254
cn6	Ezh2^tm1Tara/Ezh2^tm1Tara Igh^tm2Cgn/? Tg(Mx1-cre)1Cgn/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4440625
cx7	Igh^tm2Cgn/Igh⁺ Igk^tm1Rsky/Igk⁺	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)	MGI:3689733
cx8	Igh^tm2Cgn/Igh⁺ Igk^tm2Rsky/Igk⁺	involves: 129P2/OlaHsd	MGI:3851175
cx9	Igh^tm2Cgn/Igh^tm2Cgn Igk^tm1Rsky/Igk^tm1Rsky Trp53^tm1Tyj/Trp53^tm1Tyj Xrcc4^tm1Fwa/Xrcc4^tm1Fwa	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac	MGI:4437907
cx10	Igh^tm2Cgn/Igh^tm2Cgn Igk^tm1Rsky/Igk^tm1Rsky Lig4^tm1Fwa/Lig4^tm1Fwa Trp53^tm1Tyj/Trp53^tm1Tyj	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac	MGI:4437910
cx11	Igh^tm2Cgn/Igh⁺ Xrcc6^tm1Fwa/Xrcc6^tm1Fwa	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6	MGI:3769719
cx12	Igh^tm2Cgn/Igh⁺ Rr158^tm1Cgn/Rr158^tm1Cgn Arhgef1^tm1.1Rmt/Arhgef1^tm1.1Rmt	involves: 129P2/OlaHsd * C57BL/6	MGI:3687248
cx13	Fnip1^tm1.2Baba/Fnip1^tm1.2Baba Igh^tm2Cgn/Igh^tm2Cgn	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5445167
cx14	Fnip1^{Gt(RRM154)Byg}/Fnip1^{Gt(RRM154)Byg} Igh^tm2Cgn/Igh^tm2Cgn	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL	MGI:5445168
cx15	Igh^tm2Cgn/Igh⁺ Igk^tm2Rsky/Igk⁺ Prkdc^scid/Prkdc^scid	involves: 129P2/OlaHsd * BALB/c * C57BL/Ka	MGI:3851176

Allelic Composition	Igh^tm2Cgn/Igh⁺
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/Ka

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:79556 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type

hematopoietic system

abnormal B cell differentiation ( J:79556 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type

Allelic Composition	Igh^tm2Cgn/Igh⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal immunoglobulin light chain V-J recombination ( J:144033 )

• the percentage of B cells expressing lambda light chain is about 2 times higher than in wild-type mice

immune system

abnormal immunoglobulin light chain V-J recombination ( J:144033 )

• the percentage of B cells expressing lambda light chain is about 2 times higher than in wild-type mice

Allelic Composition	Igh^tm2Cgn/Igh^tm4.1Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)
Igh^tm4.1Fwa mutation (0 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal immunoglobulin V(D)J recombination ( J:176649 )

• the frequency of recombination is shifted and more non-productive rearrangements are produced

immune system

abnormal immunoglobulin V(D)J recombination ( J:176649 )

• the frequency of recombination is shifted and more non-productive rearrangements are produced

Allelic Composition	Igh^tm2Cgn/Igh^tm3Cgn
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/6 * C57BL/Ka

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)
Igh^tm3Cgn mutation (0 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:79556 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type

hematopoietic system

abnormal B cell differentiation ( J:79556 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type

Allelic Composition	Igh^tm1Cgn/Igh^tm2Cgn
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/Ka

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm1Cgn mutation (0 available); any Igh mutation (43 available)
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:79556 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type

hematopoietic system

abnormal B cell differentiation ( J:79556 )

• reduced number of CD43+ B cell progenitors; however, the overall number of splenic B cells is similar to wild-type

Allelic Composition	Ezh2^tm1Tara/Ezh2^tm1Tara Igh^tm2Cgn/? Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ezh2^tm1Tara mutation (2 available); any Ezh2 mutation (71 available)
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:83216 )

N	• mice injected with poly(I)poly(C) exhibit normal B cell development

Allelic Composition	Igh^tm2Cgn/Igh⁺ Igk^tm1Rsky/Igk⁺
Genetic Background	either: (involves: 129P2/OlaHsd) or (involves: 129P2/OlaHsd * BALB/c)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:111431 )

• about 90% of B cells are positive for the B1-8 heavy chain

absent pre-B cells ( J:111431 )

• the CD43- sIgM- pre B cell compartment is virtually absent

hematopoietic system

abnormal B cell differentiation ( J:111431 )

• about 90% of B cells are positive for the B1-8 heavy chain

absent pre-B cells ( J:111431 )

• the CD43- sIgM- pre B cell compartment is virtually absent

Allelic Composition	Igh^tm2Cgn/Igh⁺ Igk^tm2Rsky/Igk⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)
Igk^tm2Rsky mutation (1 available); any Igk mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:150435 )

• B cells have about a 2-fold increase in class switch recombination to IgG1

immune system

abnormal class switch recombination ( J:150435 )

• B cells have about a 2-fold increase in class switch recombination to IgG1

Allelic Composition	Igh^tm2Cgn/Igh^tm2Cgn Igk^tm1Rsky/Igk^tm1Rsky Trp53^tm1Tyj/Trp53^tm1Tyj Xrcc4^tm1Fwa/Xrcc4^tm1Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)
Igk^tm1Rsky mutation (1 available); any Igk mutation (25 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
Xrcc4^tm1Fwa mutation (0 available); any Xrcc4 mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal class switch recombination ( J:126758 )

• class switching to IgG1 is 20% to 50% of wild-type

• class switching to IgG3 is 50% of wild-type

• IgH class switching is reduced compared to in wild-type B cells

cellular

increased cellular sensitivity to ionizing radiation ( J:126758 )

• in cultured B cells

spontaneous chromosome breakage ( J:126758 )

• B cell stimulated with anti-CD40 and IL4 exhibit metaphase chromosome breaks unlike similarly treated wild-type cells

hematopoietic system

abnormal class switch recombination ( J:126758 )

• class switching to IgG1 is 20% to 50% of wild-type

• class switching to IgG3 is 50% of wild-type

• IgH class switching is reduced compared to in wild-type B cells

Allelic Composition	Igh^tm2Cgn/Igh^tm2Cgn Igk^tm1Rsky/Igk^tm1Rsky Lig4^tm1Fwa/Lig4^tm1Fwa Trp53^tm1Tyj/Trp53^tm1Tyj
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)
Igk^tm1Rsky mutation (1 available); any Igk mutation (25 available)
Lig4^tm1Fwa mutation (1 available); any Lig4 mutation (44 available)
Trp53^tm1Tyj mutation (12 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:126758 )

• class switching to IgG1 in B cells stimulated with anti-CD40 plus IL4 are 50% of wild-type

immune system

abnormal class switch recombination ( J:126758 )

• class switching to IgG1 in B cells stimulated with anti-CD40 plus IL4 are 50% of wild-type

Allelic Composition	Igh^tm2Cgn/Igh⁺ Xrcc6^tm1Fwa/Xrcc6^tm1Fwa
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)
Xrcc6^tm1Fwa mutation (2 available); any Xrcc6 mutation (61 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell differentiation ( J:44361 )

• mice carrying a rearranged IgH (heavy chain) variable region from a B1-8 clone and homozygous for Xrcc6^tm1Fwa exhibit small but detectable populations of peripheral kappa-light chain expressing IgM+ B cells with functional light chain rearrangements; this indicates that some light chain rearrangment can occur in Xrcc6-deficient mice and the defect in B cell differentiation is "leaky"

hematopoietic system

abnormal B cell differentiation ( J:44361 )

Allelic Composition	Igh^tm2Cgn/Igh⁺ Rr158^tm1Cgn/Rr158^tm1Cgn Arhgef1^tm1.1Rmt/Arhgef1^tm1.1Rmt
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef1^tm1.1Rmt mutation (0 available); any Arhgef1 mutation (73 available)
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)
Rr158^tm1Cgn mutation (0 available); any Rr158 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal B cell physiology ( J:113295 )

• increase in the proportion of cells that migrate towards high sphingosine 1-phosphate (S1P) concentrations

• reduction in migratory response towards S1P induced by LPS treatment is decreased compared to wild-type

• immunization with a low dose of T cell dependent antigen (NP-CG) fails to suppress responsiveness to S1P unlike in wild-type mice; however, treatment with a high concentration of antigen does reduce S1P responsiveness

hematopoietic system

abnormal B cell physiology ( J:113295 )

• increase in the proportion of cells that migrate towards high sphingosine 1-phosphate (S1P) concentrations

• reduction in migratory response towards S1P induced by LPS treatment is decreased compared to wild-type

Allelic Composition	Fnip1^tm1.2Baba/Fnip1^tm1.2Baba Igh^tm2Cgn/Igh^tm2Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1^tm1.2Baba mutation (0 available); any Fnip1 mutation (59 available)
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells

immune system

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells

Allelic Composition	Fnip1^{Gt(RRM154)Byg}/Fnip1^{Gt(RRM154)Byg} Igh^tm2Cgn/Igh^tm2Cgn
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fnip1^{Gt(RRM154)Byg} mutation (0 available); any Fnip1 mutation (59 available)
Igh^tm2Cgn mutation (1 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells

immune system

decreased B-1 B cell number ( J:189078 )

absent B-2 B cells ( J:189078 )

absent B cells ( J:189078 )

• absence of peripheral B cells

Allelic Composition	Igh^tm2Cgn/Igh⁺ Igk^tm2Rsky/Igk⁺ Prkdc^scid/Prkdc^scid
Genetic Background	involves: 129P2/OlaHsd * BALB/c * C57BL/Ka

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:150435 )

• B cells show defects in CSR to IgG1 and IgG3 ranging from 30%?70% of controls

immune system

abnormal class switch recombination ( J:150435 )

• B cells show defects in CSR to IgG1 and IgG3 ranging from 30%?70% of controls

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