All Phenotypes Tcf3<tm4Zhu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tcf12^tm1Zhu/Tcf12⁺ Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3774553
cn2	Tcf12^tm3Zhu/Tcf12^tm3Zhu Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Cd4-cre)1Cwi/0	involves: 129S4/SvJae * C57BL/6 * DBA/2	MGI:3769738
cn3	Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3774551
cn4	Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0 Tg(TcrAND)53Hed/0	involves: 129S4/SvJae * C57BL/6 * SJL	MGI:3774552
cn5	Tcf12^tm3Zhu/Tcf12^tm3Zhu Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0	involves: 129S4/SvJae * C57BL/6 * SJL/J	MGI:3769725
cn6	Id3^tm2.1Cmu/Id3^tm2.1Cmu Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Cd4-cre)1Cwi/0	involves: 129S4/SvJaeSor * C57BL/6 * DBA/2	MGI:5305604
cn7	Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(NPHS2-cre)295Lbh/0	involves: 129S4/SvJaeSor * C57BL/6 * SJL	MGI:3715143

Allelic Composition	Tcf12^tm1Zhu/Tcf12⁺ Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12^tm1Zhu mutation (0 available); any Tcf12 mutation (74 available)
Tcf3^tm4Zhu mutation (2 available); any Tcf3 mutation (39 available)
Tg(Lck-cre)#Zhu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:75746 )

• there is a developmental block between the double negative and immature single positive stages of T cell development

increased double-negative T cell number ( J:75746 )

• 2-week old mice exhibit a dramatic accumulation of double negative T cells

increased single-positive T cell number ( J:75746 )

• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells

immune system

abnormal T cell differentiation ( J:75746 )

• there is a developmental block between the double negative and immature single positive stages of T cell development

increased double-negative T cell number ( J:75746 )

• 2-week old mice exhibit a dramatic accumulation of double negative T cells

increased single-positive T cell number ( J:75746 )

• 2-week old mice exhibit a dramatic accumulation of immature single positive T cells

Allelic Composition	Tcf12^tm3Zhu/Tcf12^tm3Zhu Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf12^tm3Zhu mutation (1 available); any Tcf12 mutation (74 available)
Tcf3^tm4Zhu mutation (2 available); any Tcf3 mutation (39 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:129171 )

• T cells prematurely acquire single positive phenotype compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:129171 )

abnormal CD8-positive, alpha beta T cell morphology ( J:129171 )

• mice present with CD+TCR- T cell population not found in controls

increased CD8-positive, alpha-beta T cell number ( J:129171 )

hematopoietic system

abnormal T cell differentiation ( J:129171 )

• T cells prematurely acquire single positive phenotype compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:129171 )

abnormal CD8-positive, alpha beta T cell morphology ( J:129171 )

• mice present with CD+TCR- T cell population not found in controls

increased CD8-positive, alpha-beta T cell number ( J:129171 )

Allelic Composition	Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm4Zhu mutation (2 available); any Tcf3 mutation (39 available)
Tg(Lck-cre)#Zhu mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:75746 )

N	• no developmental defects are observed in the B cell lineage in mice • unexpectedly, mice show normal T cell development • no reductions in total thymocytes or double-positive thymocytes, or increase in single-positive thymocytes is observed

Allelic Composition	Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Lck-cre)#Zhu/0 Tg(TcrAND)53Hed/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm4Zhu mutation (2 available); any Tcf3 mutation (39 available)
Tg(Lck-cre)#Zhu mutation (0 available)
Tg(TcrAND)53Hed mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:75746 )

N	• TCR mediated positive T cell selection is unaffected by Tcfe2a deletion in T cells, in contrast to mice with total Tcfe2a deficiency

neoplasm

neoplasm ( J:75746 )

N	• in contrast to totally Tcfe2a-deficient mice, T cell specific Tcfe2a-deficient mice do not develop thymic lymphomas between 4 and 16 months of age

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell proliferation ( J:129570 )

• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)

• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice

• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells

thymus hypoplasia ( J:129570 )

• thymus cellularity is decreased 20-fold (6.7+/-3.1x10⁶ cells compared to 134.4+/-33.4x10⁶ cells in wild-type thymus)

increased double-negative T cell number ( J:129570 )

• T cell differentiation is blocked at the double negative stage

• double negative cells make up 95% of total thymus cells compared to only 3% in wild-type mice

• the number of double negative T cells is increased 50% compared to in wild-type mice despite hypocellularity

decreased T cell number ( J:129570 )

• gamma delta T cells are reduced 2- to 4-fold compared to in wild-type mice

decreased double-positive T cell number ( J:129570 )

• mice exhibit less than 1% of the double positive T cells found in wild-type mice

hematopoietic system

increased T cell proliferation ( J:129570 )

• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)

• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice

• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells

thymus hypoplasia ( J:129570 )

• thymus cellularity is decreased 20-fold (6.7+/-3.1x10⁶ cells compared to 134.4+/-33.4x10⁶ cells in wild-type thymus)

increased double-negative T cell number ( J:129570 )

• T cell differentiation is blocked at the double negative stage

• double negative cells make up 95% of total thymus cells compared to only 3% in wild-type mice

• the number of double negative T cells is increased 50% compared to in wild-type mice despite hypocellularity

decreased T cell number ( J:129570 )

• gamma delta T cells are reduced 2- to 4-fold compared to in wild-type mice

decreased double-positive T cell number ( J:129570 )

• mice exhibit less than 1% of the double positive T cells found in wild-type mice

endocrine/exocrine glands

thymus hypoplasia ( J:129570 )

• thymus cellularity is decreased 20-fold (6.7+/-3.1x10⁶ cells compared to 134.4+/-33.4x10⁶ cells in wild-type thymus)

cellular

increased T cell proliferation ( J:129570 )

• double negative 3 thymocytes exhibit a 1.5-fold increase in proliferation (20.1% proliferation compared to 12.7% proliferation in wild-type mice)

• double negative T cell proliferation in response to IL-7 is increased 3- to 4-fold compared to in wild-type mice

• double negative 3 thymocytes exhibit hyperproliferation in response to IL-7 compared to wild-type cells

Allelic Composition	Id3^tm2.1Cmu/Id3^tm2.1Cmu Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Id3^tm2.1Cmu mutation (0 available); any Id3 mutation (16 available)
Tcf3^tm4Zhu mutation (2 available); any Tcf3 mutation (39 available)
Tg(Cd4-cre)1Cwi mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:176462 )

N	• T follicular helper cell development is restored compared with Id3^tm2.1Cmu homozygotes

decreased thymocyte number ( J:176462 )

• partially restored compared with Id3^tm2.1Cmu homozygotes

hematopoietic system

decreased thymocyte number ( J:176462 )

• partially restored compared with Id3^tm2.1Cmu homozygotes

endocrine/exocrine glands

decreased thymocyte number ( J:176462 )

• partially restored compared with Id3^tm2.1Cmu homozygotes

Allelic Composition	Tcf3^tm4Zhu/Tcf3^tm4Zhu Tg(NPHS2-cre)295Lbh/0
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3^tm4Zhu mutation (2 available); any Tcf3 mutation (39 available)
Tg(NPHS2-cre)295Lbh mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:122505 )

• mice survive for at least 6 months without displaying any signs of renal failure, albuminuria, or structural alterations in podocytes or glomerular basement membrane

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