reproductive system
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• testis weight is slightly decreased
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• in stages XI and XII, elongating spermatids display abnormal head shapes and lack of visible tails
• however, spermatogonia, spermatocytes and round spermatids appear normal
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• the few mature spermatozoa collected from the cauda epididymis show abnormal tail morphology
• overall structure of cauda epididymal sperm is severely disorganized and no correct axonemal or accessory structures are found
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• elongating spermatids show displacement of the outer dense fibers (ODFs)
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• elongating spermatids lack a normal axonemal structure and show displacement of the microtubules
• in mature sperm, the axonemal acetylated alpha-tubulin is concentrated in the excess of cytoplasm
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• elongating spermatids show a disorganized mitochondrial sheath with displacement of the mitochondria
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• in mature sperm, the fibrous sheath component AKAP4 is concentrated in the excess of cytoplasm
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• only a few mature spermatozoa are recovered from the cauda epididymis
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• the few mature spermatozoa collected from the cauda epididymis show abnormal head morphology
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• step 13 spermatids show defects in chromatin condensation
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• steps 9-16 elongating spermatids show absence of normal sperm tail formation and malformed, knob-like, elongated head shapes
• elongating spermatids lack a normal axonemal structure and show displacement of the microtubules, outer dense fibers (ODFs), fibrous sheath and mitochondria
• step 13 spermatids show defects in chromatin condensation
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• starting at step 11, elongating spermatids exhibit an abnormally elongated manchette and a nuclear constriction is observed at the juncture of the groove and perinuclear ring
• during steps 11-12, MNS1 (meiosis-specific nuclear structural protein 1), a KIF3A-interacting protein, is abnormally concentrated in the manchette
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• in stages I-II, the manchette is abnormally retained, indicating a delay in manchette clearance
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• early elongating spermatids (steps 9-11) often show an perinuclear ring that is detached from the nucleus
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• early elongating spermatids (steps 9-11) often show an ectopically placed and thicker manchette while the perinuclear ring is detached from the nucleus
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• starting at step 11, elongating spermatids exhibit an abnormally elongated manchette
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• epididymis is filled with cell debris
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• cauda epididymis is almost completely devoid of spermatozoa
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• epididymis weight is slightly decreased
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• adult males failed to produce progeny after 6 weeks of breeding with wild-type females
• however, vaginal plugs are detected in paired females
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cellular
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• the few mature spermatozoa collected from the cauda epididymis show abnormal tail morphology
• overall structure of cauda epididymal sperm is severely disorganized and no correct axonemal or accessory structures are found
|
|
• elongating spermatids show displacement of the outer dense fibers (ODFs)
|
|
• elongating spermatids lack a normal axonemal structure and show displacement of the microtubules
• in mature sperm, the axonemal acetylated alpha-tubulin is concentrated in the excess of cytoplasm
|
|
• elongating spermatids show a disorganized mitochondrial sheath with displacement of the mitochondria
|
|
• in mature sperm, the fibrous sheath component AKAP4 is concentrated in the excess of cytoplasm
|
|
• only a few mature spermatozoa are recovered from the cauda epididymis
|
|
• the few mature spermatozoa collected from the cauda epididymis show abnormal head morphology
|
|
• step 13 spermatids show defects in chromatin condensation
|
|
• steps 9-16 elongating spermatids show absence of normal sperm tail formation and malformed, knob-like, elongated head shapes
• elongating spermatids lack a normal axonemal structure and show displacement of the microtubules, outer dense fibers (ODFs), fibrous sheath and mitochondria
• step 13 spermatids show defects in chromatin condensation
|
|
• starting at step 11, elongating spermatids exhibit an abnormally elongated manchette and a nuclear constriction is observed at the juncture of the groove and perinuclear ring
• during steps 11-12, MNS1 (meiosis-specific nuclear structural protein 1), a KIF3A-interacting protein, is abnormally concentrated in the manchette
|
|
• in stages I-II, the manchette is abnormally retained, indicating a delay in manchette clearance
|
|
• early elongating spermatids (steps 9-11) often show an perinuclear ring that is detached from the nucleus
|
|
• early elongating spermatids (steps 9-11) often show an ectopically placed and thicker manchette while the perinuclear ring is detached from the nucleus
|
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• starting at step 11, elongating spermatids exhibit an abnormally elongated manchette
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endocrine/exocrine glands
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• testis weight is slightly decreased
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