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Phenotype Image Detail
Image
Caption Polycystic kideny disease in Kif3atm1Gsn/Kif3atm2Gsn Tg(Cdh16-cre)91Igr/0 mutant mice. (A) Gross appearance of kidneys from a Kif3atm1Gsn/Kif3atm2Gsn Tg(Cdh16-cre)91Igr/0 mutant (Cre;Kif3afl/-; left) and a wild-type (Kif3a+/+) littermate (right) at P28. (B) Hematoxylin/eosin-stained sections of kidneys from mutants at different ages. (C) Blood urea nitrogen of mutant mice (red) and control littermates (blue). Error bars = SEM. *, statistically different from control (P < 0.001, Student's t test). (D-F) Staining of cystic kidneys at P21 for AQP2 (green) and Tamm-Horsfall protein (red) (D), Lotus tetragonolobus agglutinin (green) and Na-K-Cl cotransporter (red) (E), and Na-Cl cotransporter (red) (F). Nuclei were counterstained with 4',6-diamidino-2-phenylindole (blue). cy, cyst; pt, proximal tubule. [Bars = 1 mm (A), 80 um (B), and 30 um (D-F).]
Copyright This image is from Lin F, Proc Natl Acad Sci U S A 2003 Apr 29;100(9):5286-91. Copyright 2003 National Academy of Sciences, U.S.A. J:83293
Associated
Alleles
Symbol Name
Kif3atm1Gsn kinesin family member 3A; targeted mutation 1, Lawrence SB Goldstein
Kif3atm2Gsn kinesin family member 3A; targeted mutation 2, Lawrence SB Goldstein
Tg(Cdh16-cre)91Igr transgene insertion 91, Peter Igarashi
Associated
Genotypes
Allelic Composition Genetic Background
Kif3atm1Gsn/Kif3atm2Gsn
Tg(Cdh16-cre)91Igr/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
MGI 6.23 		The Jackson Laboratory