Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation
(1 available);
any
Mapk8 mutation
(71 available)
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homeostasis/metabolism
adipose tissue
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• on a high fat high calorie diet the weight of the subcutaneous fat depot is reduced by 33% compared to wild-type
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• on a high fat high calorie diet total body adiposity is decreased compared to wild-type
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• on a high fat high calorie diet adipocytes are smaller compared to wild-type mice
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• the weight of the epididymal fat pad is increased compared to wild-type
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growth/size/body
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• on a high fat high calorie diet homozygotes do not gain as much weight as wild-type mice
however, on a normal diet body weight is similar to wild-type
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integument
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• on a high fat high calorie diet the weight of the subcutaneous fat depot is reduced by 33% compared to wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation
(1 available);
any
Mapk8 mutation
(71 available)
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immune system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
• after 24 hours of culture with low concentrations of anti-CD3 and anti-CD28 antibodies homozygous T cells produce less IL2
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• reduced proliferation of lymph node but not splenic T cells after stimulation with low concentrations of anti-CD3 antibody
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells
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hematopoietic system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
• after 24 hours of culture with low concentrations of anti-CD3 and anti-CD28 antibodies homozygous T cells produce less IL2
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• reduced proliferation of lymph node but not splenic T cells after stimulation with low concentrations of anti-CD3 antibody
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells
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cellular
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus; however T and B cell development and B cell activation are normal
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• reduced proliferation of lymph node but not splenic T cells after stimulation with low concentrations of anti-CD3 antibody
• however, the addition of IL2 to the culture medium increases T cell proliferation to a level similar to that of wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapk8tm1Wag mutation
(1 available);
any
Mapk8 mutation
(71 available)
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vision/eye
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N |
• normal thickness, cell count and cell density of retina INL and GCL at age P30
• normal lamination of retina at age P7, P14 and P30
• normal cell counts for retinal ganglion, horizontal, bipolar, amacrine, and Mueller cells
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• 2.7-fold increase in S-opsin- and 5-fold increase in M-opsin-positive cells at age P30
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• 1.4-fold increase in rhodopsin-positive cells at age P30
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• increased density and cell count at age P30
• normal thickness though trending towards slightly thicker at age P30
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• under photopic and scotopic conditions at age 1 month and 2 months
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nervous system
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• 2.7-fold increase in S-opsin- and 5-fold increase in M-opsin-positive cells at age P30
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• 1.4-fold increase in rhodopsin-positive cells at age P30
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neoplasm
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• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice
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respiratory system
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• following adenovirus cre infection, mice exhibit increased lung tumor burden compared with control mice
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growth/size/body
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• decreased weight gain relative to Lepob single homozygotes
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homeostasis/metabolism
immune system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote
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hematopoietic system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote
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cellular
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote
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immune system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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hematopoietic system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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cellular
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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immune system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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hematopoietic system
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote or in the double heterozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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cellular
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• anti-CD3 antibody stimulated double positive T cell apoptosis is reduced in the thymus similar to the reduction seen in either single homozygote
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• lymph node T cells display reduced proliferation in response to low concentrations of anti-CD3 antibody similar to either single homozygote or in the double heterozygote
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mortality/aging
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• fewer than expected mice are found at weaning; however expected numbers are found at E12.5 to E15.5
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nervous system
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• at E12.5 the neural tube is open over the complete antero-dorsal extent of the brain in exencephalic mice
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• at E15.5 in exencephalic mice, the brain tissue is expanded upward
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• abnormal folding of the neuroepithelium is seen in exencephalic mice at E12.5
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• at E12.5, in exencephalic mice the cerebral ventricles are absent
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• at E15.5 in exencephalic mice, the diencephalon is enlarged
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• at E15.5 in exencephalic mice, the cerebral hemispheres are displaced laterally
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• some embryos display exencephaly with absence of the entire creanial roof at E12.5
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embryo
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• abnormal folding of the neuroepithelium is seen in exencephalic mice at E12.5
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• at E12.5 the neural tube is open over the complete antero-dorsal extent of the brain in exencephalic mice
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mortality/aging
nervous system
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• at E9.25, reduced apoptosis is seen in the hindbrain especially along the edges of the neural folds
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• at E10.5 increased apoptosis is seen in the forebrain neuroepithelium, especially in the lamina terminalis, the optic stalk and the trigeminal ganglia; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• at E10.5 increased apoptosis is seen in hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• the neuroepithelium is thickened and everted at the level of the fourth ventricle
• at E10.5 increased apoptosis is seen in the forebrain and hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• neural fold in the hindbrain region are elevated but the lateral edges do not bend medially to fuse
• this defect begins at the midbrain/hindbrain boundary and extends to the cervical/hinbrain boundary; however the forebrain and spinal neural folds are fused
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• the lumen of the forebrain vesicles is incompletely formed
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growth/size/body
homeostasis/metabolism
embryo
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• the neuroepithelium is thickened and everted at the level of the fourth ventricle
• at E10.5 increased apoptosis is seen in the forebrain and hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• neural fold in the hindbrain region are elevated but the lateral edges do not bend medially to fuse
• this defect begins at the midbrain/hindbrain boundary and extends to the cervical/hinbrain boundary; however the forebrain and spinal neural folds are fused
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cellular
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• at E9.25, reduced apoptosis is seen in the hindbrain especially along the edges of the neural folds
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• at E10.5 increased apoptosis is seen in the forebrain neuroepithelium, especially in the lamina terminalis, the optic stalk and the trigeminal ganglia; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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• at E10.5 increased apoptosis is seen in hindbrain neuroepithelium; however, no difference is seen at E9.25 or E10.5 in the number of proliferating cells
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nervous system
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N |
• no mice display exencephaly and no indications of increased mortality are seen
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map3k1tm1Yxia mutation
(0 available);
any
Map3k1 mutation
(62 available)
Mapk8tm1Wag mutation
(1 available);
any
Mapk8 mutation
(71 available)
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vision/eye
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• eyes are open at birth
• however, mice exhibit normal retinal morphology
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vision/eye
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• eyes are open at birth
• however, mice exhibit normal retinal morphology
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vision/eye
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• mice exhibit an eyelid closure defect compared with wild-type mice
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Analysis Tools