Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
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mortality/aging
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• peri-implantation lethality
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
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mortality/aging
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• 50% dead prior to E5.5, 50% dead between E5.5 and E9.5
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Allelic Composition |
Pafah1b1tm1Awb/Pafah1b1+
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Genetic Background |
involves: 129S6/SvEvTac |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
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Disruption of hippocampal layers in Lrp8tm1Her/Lrp8tm1Her, Pafah1b1tm1Awb/Pafah1b1+, and Lrp8tm1Her/Lrp8tm1Her Pafah1b1tm1Awb/Pafah1b1+ mice
nervous system
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• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone
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• migration defects in the hippocampus are seen
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• mutants exhibit a modest split of the pyramidal layer in area CA1 and CA3
• however, do not show an obvious cerebral cortical layering defects
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• a mild reduction in the number of cells in the neocortex is seen with preferential loss of later migrating cells
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cellular
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• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone
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• migration defects in the hippocampus are seen
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Allelic Composition |
Pafah1b1tm1Awb/Pafah1b1+
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Genetic Background |
involves: 129S6/SvEvTac * NIH Black Swiss |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
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behavior/neurological
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• impaired in Morris water task
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• abnormal clasping of hind paws on tail and wire suspension tests
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• as observed in a rotarod test
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nervous system
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• neuronal migration slow or delayed
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
Pafah1b1tm2Awb mutation
(1 available);
any
Pafah1b1 mutation
(159 available)
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mortality/aging
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• all dead by two weeks of age
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growth/size/body
nervous system
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• broad, discontinuous stratum pyrimadale
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Allelic Composition |
Pafah1b1tm1Awb/Pafah1b1+ Ywhaetm1Awb/Ywhae+
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Genetic Background |
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Black Swiss) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
Ywhaetm1Awb mutation
(1 available);
any
Ywhae mutation
(62 available)
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nervous system
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• neuronal migration distances in the cortex and in the hippocampus are shorter than in mice heterozygous for only one of these two loci
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• very severe abnormalities in pyramidal cell packing as compared to mice heterozygous at only one of these two loci
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cellular
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• neuronal migration distances in the cortex and in the hippocampus are shorter than in mice heterozygous for only one of these two loci
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nde1tm1Caw mutation
(1 available);
any
Nde1 mutation
(32 available)
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
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nervous system
N |
• normal size and shape of dorsal root ganglia
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• expanded roof plate
• cells continue to divide through E13
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• massive expansion of choroid plexus epithelium cells
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• profound loss of neocortical neurons
• extensive loss of neurons in the dorsal spinal cord
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• large number of dorsal sensory interneurons are missing
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• near complete loss of dorsal sensory interneurons with only modest losses in the ventral spinal cord
• dorsal progenitors are greatly reduced distal to the roof plate
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• ventral spinal cord patterning and dorsal most domain of the ventral spinal cord are only modestly affected
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embryo
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• expanded roof plate
• cells continue to divide through E13
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ndel1tm1.1Shr mutation
(0 available);
any
Ndel1 mutation
(40 available)
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
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nervous system
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• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone
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• migration defects in the hippocampus are slightly more severe than in Pafah1b1 single heterozygotes with the number of cells the reached layer II now reduced
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• dendritic extensions of postmiotic neurons in the cortical plate are irregular and fragmented
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• a mild reduction in the number of cells in the neocortex is seen with preferential loss of later migrating cells
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cellular
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• at E15.5, but not at E11.5, increased apoptosis is seen in the ventricular zone
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• migration defects in the hippocampus are slightly more severe than in Pafah1b1 single heterozygotes with the number of cells the reached layer II now reduced
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
Pafah1b2Gt(Betageo)1Cla mutation
(0 available);
any
Pafah1b2 mutation
(20 available)
Pafah1b3tm1Cla mutation
(0 available);
any
Pafah1b3 mutation
(13 available)
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Testicular phenotypes of mice having various combinations of Pafah1b1tm1Awb, Pafah1b2Gt(Betageo)1Cla and Pafah1b3tm1Cla alleles
reproductive system
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• some degenerating germ cells are seen
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• occasional multinucleated giant cells are seen in the seminiferous epithelium
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• testis weigh about 20% less than that of control mice
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cellular
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• some degenerating germ cells are seen
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endocrine/exocrine glands
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• occasional multinucleated giant cells are seen in the seminiferous epithelium
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• testis weigh about 20% less than that of control mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
Vldlrtm1Her mutation
(1 available);
any
Vldlr mutation
(69 available)
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nervous system
N |
• cerebral cortex appears fairly normal
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lrp8tm1Her mutation
(1 available);
any
Lrp8 mutation
(41 available)
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
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Disruption of hippocampal layers in Lrp8tm1Her/Lrp8tm1Her, Pafah1b1tm1Awb/Pafah1b1+, and Lrp8tm1Her/Lrp8tm1Her Pafah1b1tm1Awb/Pafah1b1+ mice
nervous system
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• profound dyslamination of all cellular layers in the hippocampus
• however, no gross abnormalities are seen in the cerebellum
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• inversion of cortical layers
• cortex shows hypercellularity of layer I
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braptm1.1Yfng mutation
(0 available);
any
Brap mutation
(30 available)
Pafah1b1tm1Awb mutation
(0 available);
any
Pafah1b1 mutation
(159 available)
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mortality/aging
growth/size/body
nervous system
cellular
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• less than 60% of neuron progenitors with properly positioned metaphase chromosomes
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embryo