Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
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normal phenotype
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• mice are viable and fertile; no gross morphological or behavioral abnormalities
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm2Cgh mutation
(0 available);
any
Gna13 mutation
(12 available)
Grhl3tm1(cre)Cgh mutation
(1 available);
any
Grhl3 mutation
(53 available)
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mortality/aging
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• mutants die by 10.5 days post coitus (dpc)
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embryo
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• embryos display turning defects and other defects, but the hindbrain neuropore is closed in mutants at 10.5 dpc
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• embryos show turning defects
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm2.1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
Tg(Tek-icre/ERT2)1Soff mutation
(1 available)
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cardiovascular system
N |
• tamoxifen-treated mice respond similar to wild-type controls in experiments testing response to anaphylactic shock
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation
(11 available);
any
Cd19 mutation
(56 available)
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm2.1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
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hematopoietic system
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• marginal zone B cell numbers are strongly reduced compared to controls
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• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells
• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells
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immune system
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• marginal zone B cell numbers are strongly reduced compared to controls
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• lysophospholipid-induced induced adhesion is completely abrogated in marginal zone mutant B cells and is reduced in follicular B cells
• lysophospholipid-induced induced LFA-1 (integrin) clustering is abolished in mutant B cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm2.1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
Tg(Lck-cre)548Jxm mutation
(2 available)
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immune system
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• homeostatic CD4+ T cell proliferation is increased within the lymph nodes
• allogenic stimulation of CD4+ T cells is also increased
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• thymus weight and cellularity is increased by about a third
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• CD4+ T cell numbers in the lymph nodes and blood are increased by about a third
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• CD8+ T cell numbers in the lymph nodes are slightly increased
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• CD4+ T cells have longer interactions between themselves and with allogenic dendritic cells
• CD4+ T cells have a higher affinity for ICAM-coated surfaces
• CD4+ T cells have decreased motility through transwell filters
• CD4+ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes
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• axillary, cervical, inguinal and mesenteric lymph nodes are increased in weight and cell number by about a third
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• an increase in ear thickness is observed after sensitization and challenge with DNFB
• CD4+ T cells in cervical lymph nodes have a higher proliferation rate than those of control mice after DNFB challenge
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• IL-2 secretion is enhanced by CD4+ T cells in response to allogenic stimulation
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• diabetes development is accelerated and aggravated after streptozotocin induction with high glucose levels detected
• peripancreatic lymph nodes are enlarged 5-6 days after disease induction
• increased numbers of CD4+ T cells are noted in the pancreas 14 days after disease induction compared to controls
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hematopoietic system
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• homeostatic CD4+ T cell proliferation is increased within the lymph nodes
• allogenic stimulation of CD4+ T cells is also increased
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• thymus weight and cellularity is increased by about a third
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• CD4+ T cell numbers in the lymph nodes and blood are increased by about a third
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• CD8+ T cell numbers in the lymph nodes are slightly increased
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• CD4+ T cells have longer interactions between themselves and with allogenic dendritic cells
• CD4+ T cells have a higher affinity for ICAM-coated surfaces
• CD4+ T cells have decreased motility through transwell filters
• CD4+ T cells transferred into wild-type mice have enhanced enhanced transendothelial migration into lymph nodes
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endocrine/exocrine glands
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• thymus weight and cellularity is increased by about a third
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cellular
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• homeostatic CD4+ T cell proliferation is increased within the lymph nodes
• allogenic stimulation of CD4+ T cells is also increased
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm2.1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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homeostasis/metabolism
hematopoietic system
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• serotonin secretion induced by U46619 plus adrenaline or Par-4 peptide exposure is significantly decreased compared to wild-type cells
• however, thrombin-induced serotonin secretion is not impaired
• absence of a shape change in response to low concentration of stimuli compared to wild-type following polyinosinic-polycytidylic acid (PIPC) treatment
• however, shape change is induced with high concentration of stimuli
• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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• potency of agonists to induce aggregation is reduced but aggregation occurs at all agonist concentrations
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm2.1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
Tg(Myh11-icre/ERT2)1Soff mutation
(2 available)
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cardiovascular system
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• tamoxifen-treated mice exhibit decreased blood pressure following treatment with U46619, vasopressin and endothelin compared to in wild-type mice
• tamoxifen-treated mice exposed to DOCA-salt do not develop hypertension and DOCA-salt treated mice exposed to tamoxifen following the onset of hypertension exhibit a drop in blood pressure compared to in similarly treated wild-type mice
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• tamoxifen-treated mice exhibit reduced vasocontraction in response to angiotensin II, U46619 and endothelin-1 compared to in similarly treated wild-type mice
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muscle
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• tamoxifen-treated mice exhibit reduced vasocontraction in response to angiotensin II, U46619 and endothelin-1 compared to in similarly treated wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
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mortality/aging
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• resorbed by E9.5 with severe necrosis
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embryo
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
|
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normal phenotype
|
• mice are viable and fertile
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gna13tm1Soff mutation
(0 available);
any
Gna13 mutation
(12 available)
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gnaqtm1Soff mutation
(1 available);
any
Gnaq mutation
(24 available)
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mortality/aging
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• mutant embryos appear normal until E12, then development appears to stop; embryos begin resorbtion at E13.5
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gna12tm1Citb mutation
(0 available);
any
Gna12 mutation
(21 available)
Gnaqtm1Soff mutation
(1 available);
any
Gnaq mutation
(24 available)
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mortality/aging
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• fewer than expected homozygotes were present at P30
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