Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pim1tm1Pwl mutation
(0 available);
any
Pim1 mutation
(15 available)
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hematopoietic system
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• hemoglobin levels are decreased due to reduced cell volume without any increase in cell numbers
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• mean cell volume of erythrocytes is significantly smaller than controls
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• proliferative response of bone marrow mast cells to Il-3 stimulation was severely impaired
(J:14715)
• apoptosis occurs more slowly on removal of Il-3 from bone marrow mast cells in culture than from wild-type cells
(J:15259)
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immune system
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• proliferative response of bone marrow mast cells to Il-3 stimulation was severely impaired
(J:14715)
• apoptosis occurs more slowly on removal of Il-3 from bone marrow mast cells in culture than from wild-type cells
(J:15259)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pim1tm1Pwl mutation
(0 available);
any
Pim1 mutation
(15 available)
Pim2tm1Brn mutation
(0 available);
any
Pim2 mutation
(6 available)
Pim3tm1Brn mutation
(0 available);
any
Pim3 mutation
(6 available)
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growth/size/body
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• neonates are smaller compared to wild-type and littermates that are not homozygous for at least one of the loci
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• mutants are about 30% smaller compared to wild-type and littermates that are not homozygous at at least one of the loci
• all organs, except for the thymus, are decreased in size in proportion to the reduced body size as a result of a decrease in cell number
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hematopoietic system
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• B cell proliferation in response to IL-7 is significantly impaired in the bone marrow
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• T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and IL2
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• the fraction of pre-pro-B cells is increased in the bone marrow
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• the fraction of late pro-B cells is slightly decreased
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• fewer and hypoproliferative megakaryocytes are seen in spleen sections
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• the erythroid progenitor fraction in the spleen is increased
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• a slight increase in erythrocyte numbers is seen without an increase in hematocrit
• the number of mature erthrocytes is also increased in the spleen
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• mean erythrocyte cell volume is decreased
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• the fraction of splenic B cell is reduced about 25% at 8 weeks but returns to normal by 20 weeks
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• the fraction of pre-B cells especially of late pre-B cells is decreased in the bone marrow
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immune system
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• B cell proliferation in response to IL-7 is significantly impaired in the bone marrow
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• T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and IL2
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• the fraction of pre-pro-B cells is increased in the bone marrow
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• the fraction of late pro-B cells is slightly decreased
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• the fraction of splenic B cell is reduced about 25% at 8 weeks but returns to normal by 20 weeks
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• the fraction of pre-B cells especially of late pre-B cells is decreased in the bone marrow
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cellular
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• B cell proliferation in response to IL-7 is significantly impaired in the bone marrow
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• T cell proliferation is reduced in response to suboptimal levels of alphaCD3 and IL2
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Analysis Tools