Pim2^tm1Brn
Targeted Allele Detail

Summary

• Symbol: Pim2^tm1Brn
• Name: proviral integration site 2; targeted mutation 1, Anton Berns
• MGI ID: MGI:3050662
• Synonyms: Pim2^-
• Gene: Pim2 Location: ChrX:7744545-7749671 bp, + strand Genetic Position: ChrX, 3.55 cM
• Alliance: Pim2^tm1Brn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:91592
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-hygromycin gene replaced exons 1-3. Southern blot confirmed recombination. RT-PCR indicated absence of mRNA. (J:91592)

Expression

In Mice Carrying this Mutation:

6 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pim2 Mutation: 6 strains or lines available

References

• Original: J:91592 Mikkers H, et al., Mice deficient for all PIM kinases display reduced body size and impaired responses to hematopoietic growth factors. Mol Cell Biol. 2004 Jul;24(13):6104-15
• All: 18 reference(s)