Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elanetm1(cre)Roes mutation
(5 available);
any
Elane mutation
(21 available)
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mortality/aging
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• median survival time is increased to 477 +/- 88 min compared to 435 +/- 8 min in wild-type mice
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• after infection with 500,000 A. fumigatus spores only 60% of homozygotes survived more than 21 days compared to all wild-type mice surviving
• 6 days after infection kidney fungal load (304 mean CFU) is higher than in wild-type (16 mean CFU) but lower than in Ctsg and Ela double homozygotes (1009 mean CFU)
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immune system
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• median survival time is increased to 477 +/- 88 min compared to 435 +/- 8 min in wild-type mice
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• after infection with 500,000 A. fumigatus spores only 60% of homozygotes survived more than 21 days compared to all wild-type mice surviving
• 6 days after infection kidney fungal load (304 mean CFU) is higher than in wild-type (16 mean CFU) but lower than in Ctsg and Ela double homozygotes (1009 mean CFU)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elanetm1(cre)Roes mutation
(5 available);
any
Elane mutation
(21 available)
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immune system
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• in the reverse passive Arthus reaction model of immune complex-mediated inflammation neutrophil infiltration to sites of immune complex formation is marginally reduced
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hematopoietic system
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• in the reverse passive Arthus reaction model of immune complex-mediated inflammation neutrophil infiltration to sites of immune complex formation is marginally reduced
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hematopoietic system
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• increased myelopoietic activity in bone marrow
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• increased cell adhesion
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immune system
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• increased myelopoietic activity in bone marrow
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• increased cell adhesion
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• inflammatory disorder in almost all mice after 6 weeks of age of CD4
• dermatitis-like symptomes
• inflammation of eyelids and ears
• acute pulmonary inflammation and perivascular accumulation of polymorphonuclear granulocytes
• granulocytic infiltration of dorsal deep dermis and subcutis of extremities
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• increased sensitivity to lipopolysaccharide
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immune system
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• after injection of 100ng LPS along with D-galactosamine 54% of double homozygotes survive compared to only 9% of wild-type mice and median survival time is increased to 935 +/- 227 min compared to 435 +/- 8 min in wild-type mice
• LPS-induced increases in serum TNF, recruitment of neutrophils into the liver, and liver damage are all normal; however vascular and lung damage are reduced
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• after infection with 500,000 A. fumigatus spores median survival time was only 10 +/- 3 days compared to wild-type mice which all survive
• infection with a lower concentration of spores, at which all single homozygotes survive, resulted in the death of 60% of double homozygotes
• 6 days after infection kidney fungal load is 1009 mean CFU much higher than wild-type (16 mean CFU) or either single homozygote
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Analysis Tools