About   Help   FAQ
Targeted Allele Detail
Symbol: Elanetm1(cre)Roes
Name: elastase, neutrophil expressed; targeted mutation 1, Jurgen Roes
MGI ID: MGI:2182177
Synonyms: ElaCre, GE-, GEcre, NE-
Gene: Elane  Location: Chr10:79722146-79724050 bp, + strand  Genetic Position: Chr10, 39.72 cM
Alliance: Elanetm1(cre)Roes page
Germline Transmission:  Earliest citation of germline transmission: J:77597
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Recombinase)
Mutation:    Insertion
Elanetm1(cre)Roes expression driven by 1 gene
Mutation detailsA construct containing a cre recombinase gene, in which GC pairs had been deleted, and a floxed neo gene, was incoporated at the start codon of the endogenous gene. The floxed neo gene was excised in vitro by transiently transfecting ES cells with cre expression vectors. Neither transcript nor protein were detected by Northern and Western blot analyses. Expression of the modified cre transgene permits conditional mutagenesis at sites tagged with loxP in myeloid precursor cells. (J:77597)
 Tissue activity of this recombinase allele
Driver: Elane (mouse)
Summary of all recombinase alleles driven by Elane.

View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Elane Mutation:  22 strains or lines available
Original:  J:77597 Tkalcevic J, et al., Impaired immunity and enhanced resistance to endotoxin in the absence of neutrophil elastase and cathepsin G. Immunity. 2000 Feb;12(2):201-10
All:  22 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
MGI 6.24
The Jackson Laboratory