Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm1Glm mutation
(0 available);
any
Nfatc1 mutation
(47 available)
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cardiovascular system
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• at E11.5, a significant decrease in proliferation of endocardial cells in the proximal outflow tract (pOFT) is observed; by E13.5 this decrease is more pronounced at the leading edge of the primitive semilunar valves
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• at E11.5, a significant decrease in proliferation of cushion mesenchyme in the AVC
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• no elevated apoptosis is detected after E12.5 in mutants in contrast to wild-type controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm1Glm mutation
(0 available);
any
Nfatc1 mutation
(47 available)
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mortality/aging
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• no surviving homozygotes at birth and a slight reduction in heterozygotes
• embryo proportions normal at E8.5-E12.5
• increasingly fewer viable homozygotes from E13.5-E17.5
• E14.5 embryos are pale
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cardiovascular system
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• blood flow indices significantly lower than controls at E11.5-E14.5
• increased aortic flow to the placenta from E12.5-E14.5
• greater than normal umbilical pulsatility at E13.5-E14.5
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• abdominal hemorrhage at E14.5
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• blood flow reversal during diastole in more than 80% of E13.5-E14.5 embryos
• blood flow abnormal in only 19.5% of E10.5 embryos
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homeostasis/metabolism
digestive/alimentary system
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• abdominal hemorrhage at E14.5
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integument
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• embryos at E14.5 are pale
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm1Glm mutation
(0 available);
any
Nfatc1 mutation
(47 available)
Nfatc1tm2Glm mutation
(0 available);
any
Nfatc1 mutation
(47 available)
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immune system
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• in all hypoplastic thymi but are blastocyst derived
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• marked deficiency of thymocytes, peripheral lymph node cells, and splenic lymphocytes in four of seven 10-22 week old chimeric mice
• inverse relationsip between the degree of chimerism and lymphoid reconsititution in five mice between 10 and 14 weeks in age
• mice at 17 and 22 weeks show normal lymphoid reconstitution
• ratio of T to B cells normal
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• decreased numbers but normal ratio of CD4+ to CD8+ single positive cells
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• diminished proliferative response to anti-CD40
• response to anti-CD40 in culture can be partially restored by recombinant Il4
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• markedly decreased
• corrollated to Il4 levels secreted by T-cells
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• markedly decreased
• corrollated to Il4 levels secreted by T-cells
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• normal to slightly decreased
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• normal to slightly decreased
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• reduced proliferative response to anti-CD3
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• impaired generation of Th2 cells
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hematopoietic system
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• in all hypoplastic thymi but are blastocyst derived
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• marked deficiency of thymocytes, peripheral lymph node cells, and splenic lymphocytes in four of seven 10-22 week old chimeric mice
• inverse relationsip between the degree of chimerism and lymphoid reconsititution in five mice between 10 and 14 weeks in age
• mice at 17 and 22 weeks show normal lymphoid reconstitution
• ratio of T to B cells normal
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• decreased numbers but normal ratio of CD4+ to CD8+ single positive cells
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• diminished proliferative response to anti-CD40
• response to anti-CD40 in culture can be partially restored by recombinant Il4
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• markedly decreased
• corrollated to Il4 levels secreted by T-cells
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• markedly decreased
• corrollated to Il4 levels secreted by T-cells
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• normal to slightly decreased
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• normal to slightly decreased
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• reduced proliferative response to anti-CD3
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• impaired generation of Th2 cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sho mutation
(4 available);
any
Gt(ROSA)26Sor mutation
(942 available)
H2az2Tg(Wnt1-cre)11Rth mutation
(2 available);
any
H2az2 mutation
(26 available)
Nfatc1tm1Glm mutation
(0 available);
any
Nfatc1 mutation
(47 available)
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cardiovascular system
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• thinning of neural crest-derived mesenchyme in the distal outflow tract (dOFT) of E12.5 embryos, affecting the formation of the base of the aortic valve
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sho mutation
(4 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Nfatc1tm1Glm mutation
(0 available);
any
Nfatc1 mutation
(47 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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cardiovascular system
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• boundary of the proximal outflow tract (pOFT) and distal outflow tract (dOFT) at the outflow tract bend is distrupted, with an extension of endocardium-derived mesenchyme into the dOFT cushion in mutants
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