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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tcratm1Mjo
targeted mutation 1, Michael J Owen
MGI:2180883
Summary 13 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tcratm1Mjo/Tcratm1Mjo involves: 129P2/OlaHsd MGI:4944216
hm2
 		Tcratm1Mjo/Tcratm1Mjo involves: 129P2/OlaHsd * BALB/c MGI:3618333
hm3
 		Tcratm1Mjo/Tcratm1Mjo involves: 129P2/OlaHsd * MRL MGI:4947950
hm4
 		Tcratm1Mjo/Tcratm1Mjo NOD.129P2-Tcratm1Mjo MGI:3623759
ht5
 		Tcratm1Mjo/Tcra+ NOD.129P2-Tcratm1Mjo MGI:4944217
ht6
 		Tcratm1Mjo/Tcra+ SJL.129P2-Tcratm1Mjo MGI:4944219
cx7
 		Tcratm1Mjo/Tcratm1Mjo
X/Yaa 		BXSB.129P2(Cg)-Tcratm1Mjo/Theo MGI:6154363
cx8
 		Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo 		involves: 129P2/OlaHsd * 129S2/SvPas * MRL MGI:4947940
cx9
 		Cd40lgtm1Flv/Y
Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo 		involves: 129P2/OlaHsd * 129S2/SvPas * MRL MGI:4947943
cx10
 		Cd40lgtm1Flv/Cd40lgtm1Flv
Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo 		involves: 129P2/OlaHsd * 129S2/SvPas * MRL MGI:4947944
cx11
 		Mpztm1Msch/Mpz+
Tcratm1Mjo/Tcratm1Mjo 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:4947953
cx12
 		Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo 		involves: 129P2/OlaHsd * MRL MGI:4944220
cx13
 		Faslpr/Faslpr
Tcratm1Mjo/Tcra+ 		MRL.Cg-Tcratm1Mjo Faslpr MGI:4944218


Genotype
MGI:4944216
hm1
Allelic
Composition		 Tcratm1Mjo/Tcratm1Mjo
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased T cell proliferation ( J:110898 )
• proliferation in response to stimulation with the mitogen Con A is reduced compared to heterozygous controls
colitis ( J:37699 )
• in specific pathogen free mice areas of the colonic mucosa with architectural disturbances also show marked neutrophilic infiltration
• inflammation is not detected in germ free or gnotobiotic mice
enlarged spleen ( J:110898 )
• in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls
spleen hyperplasia ( J:110898 )
• increase mean cell yield in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls
increased T cell number ( J:110898 )
• increase in the abundance of TCRB+ TCRA- cells in mice exposed to environmental antigens
increased gamma-delta T cell number ( J:110898 )
• increase in gamma-delta T cells in the spleen, mesenteric lymph nodes, Peyer's patch lymph nodes and peripheral lymph nodes in mice exposed to environmental antigens compared to heterozygous controls
• a substantial proportion of the gamma-delta T cells are activated
increased activated T cell number ( J:110898 )
• a substantial proportion of the gamma-delta T cells in lymph organs of mice exposed to environmental antigens are activated
enlarged mesenteric lymph nodes ( J:110898 )
• in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls

digestive/alimentary system
abnormal intestinal mucosa morphology ( J:37699 )
• in specific pathogen free mice areas of the colonic mucosa show hyperplasia, an increase in crypt fusion and crowding of the glands
• however, colon morphology is similar to wild-type controls in germ free or gnotobiotic mice
abnormal colon morphology ( J:37699 )
• in specific pathogen free mice areas of the colonic mucosa show hyperplasia, an increase in crypt fusion and crowding of the glands
rectal prolapse ( J:37699 )
• occasionally seen in specific pathogen free mice
diarrhea ( J:37699 )
• occasionally seen in specific pathogen free mice
colitis ( J:37699 )
• in specific pathogen free mice areas of the colonic mucosa with architectural disturbances also show marked neutrophilic infiltration
• inflammation is not detected in germ free or gnotobiotic mice

nervous system
abnormal neuron proliferation ( J:170591 )
• decrease in hippocampal neurogenesis

hematopoietic system
decreased T cell proliferation ( J:110898 )
• proliferation in response to stimulation with the mitogen Con A is reduced compared to heterozygous controls
enlarged spleen ( J:110898 )
• in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls
spleen hyperplasia ( J:110898 )
• increase mean cell yield in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls
increased T cell number ( J:110898 )
• increase in the abundance of TCRB+ TCRA- cells in mice exposed to environmental antigens
increased gamma-delta T cell number ( J:110898 )
• increase in gamma-delta T cells in the spleen, mesenteric lymph nodes, Peyer's patch lymph nodes and peripheral lymph nodes in mice exposed to environmental antigens compared to heterozygous controls
• a substantial proportion of the gamma-delta T cells are activated
increased activated T cell number ( J:110898 )
• a substantial proportion of the gamma-delta T cells in lymph organs of mice exposed to environmental antigens are activated

cellular
decreased T cell proliferation ( J:110898 )
• proliferation in response to stimulation with the mitogen Con A is reduced compared to heterozygous controls
abnormal neuron proliferation ( J:170591 )
• decrease in hippocampal neurogenesis

growth/size/body
enlarged spleen ( J:110898 )
• in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls
spleen hyperplasia ( J:110898 )
• increase mean cell yield in mice removed from specific pathogen free conditions and exposed to environmental antigens compared to heterozygous controls




Genotype
MGI:3618333
hm2
Allelic
Composition		 Tcratm1Mjo/Tcratm1Mjo
Genetic
Background		 involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased B cell number ( J:111129 )
• in spleens compared to heterozygous controls
abnormal T cell morphology ( J:1292 )
• alphabeta+ T cells are completely absent
increased activated T cell number ( J:111129 )
• on average 27% of the gamma-delta T cells are activated
increased IgE level ( J:111129 )
• in some mice compared to heterozygous controls
increased IgG1 level ( J:111129 )
• in some mice compared to heterozygous controls
abnormal thymus cortex morphology ( J:1292 )
• the cortices of thymi in nulls are greatly expanded and tightly packed with CD4+CD8+ cells
absent thymus medulla ( J:1292 )
• no medullae are discernible in mutant thymi
abnormal splenic cell ratio ( J:1292 )
• elimination of alphabeta+ T cells is compensated for by an increase in splenic immunoglobulin positive cells (B cells) positive for IgM and IgD
small Peyer's patches ( J:1292 )
• in mutants, these are smaller and shriveled in appearance compared to wild-type, being approximately half the size of controls
increased autoantibody level ( J:111129 )
• about 50% of sera are reactive for mammalian cell proteins compared to only about 11% of sera from heterozygous controls
• reactivity in some mice is primarily against small nuclear ribonucleoproteins
• by 5 weeks of age about 50% of mice show IgG autoantibodies in more than one assay (anti-dsDNA, anti-nuclear antigens, and immunoblotting for antibodies to mammalian cell proteins)
increased anti-nuclear antigen antibody level ( J:111129 )
• more than 80% of sera are positive for anti-nuclear antigens although the degree of reactivity varies

hematopoietic system
abnormal thymus cortex morphology ( J:1292 )
• the cortices of thymi in nulls are greatly expanded and tightly packed with CD4+CD8+ cells
absent thymus medulla ( J:1292 )
• no medullae are discernible in mutant thymi
increased B cell number ( J:111129 )
• in spleens compared to heterozygous controls
abnormal T cell morphology ( J:1292 )
• alphabeta+ T cells are completely absent
increased activated T cell number ( J:111129 )
• on average 27% of the gamma-delta T cells are activated
abnormal splenic cell ratio ( J:1292 )
• elimination of alphabeta+ T cells is compensated for by an increase in splenic immunoglobulin positive cells (B cells) positive for IgM and IgD
increased IgE level ( J:111129 )
• in some mice compared to heterozygous controls
increased IgG1 level ( J:111129 )
• in some mice compared to heterozygous controls

endocrine/exocrine glands
abnormal thymus cortex morphology ( J:1292 )
• the cortices of thymi in nulls are greatly expanded and tightly packed with CD4+CD8+ cells
absent thymus medulla ( J:1292 )
• no medullae are discernible in mutant thymi




Genotype
MGI:4947950
hm3
Allelic
Composition		 Tcratm1Mjo/Tcratm1Mjo
Genetic
Background		 involves: 129P2/OlaHsd * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
increased urine protein level ( J:45448 )
• compared to age-matched B10.A mice
abnormal kidney morphology ( J:45448 )
• develop glomerular, interstitial and sometimes perivascular lesions

homeostasis/metabolism
increased urine protein level ( J:45448 )
• compared to age-matched B10.A mice




Genotype
MGI:3623759
hm4
Allelic
Composition		 Tcratm1Mjo/Tcratm1Mjo
Genetic
Background		 NOD.129P2-Tcratm1Mjo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased activated T cell number ( J:52940 )
• when splenic T cells from BDC2.5 transgenic mice are transferred to Tcra deficient mice, significant proliferation of transferred splenocytes is detected in the pancreatic lymph nodes but not in the spleen or other lymph nodes 3 days after transfer
• when T cells from adult BDC2.5 transgenics are transferred to 10 day old or adult Tcra-deficient NOD mice, proliferation of T cells is detected after 3 days only in adult hosts in pancreatic lymph nodes

hematopoietic system
increased activated T cell number ( J:52940 )
• when splenic T cells from BDC2.5 transgenic mice are transferred to Tcra deficient mice, significant proliferation of transferred splenocytes is detected in the pancreatic lymph nodes but not in the spleen or other lymph nodes 3 days after transfer
• when T cells from adult BDC2.5 transgenics are transferred to 10 day old or adult Tcra-deficient NOD mice, proliferation of T cells is detected after 3 days only in adult hosts in pancreatic lymph nodes




Genotype
MGI:4944217
ht5
Allelic
Composition		 Tcratm1Mjo/Tcra+
Genetic
Background		 NOD.129P2-Tcratm1Mjo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell physiology ( J:108590 )
• unlike in wild-type controls no dual TCRA expressing cells are present
decreased susceptibility to autoimmune diabetes ( J:108590 )
• males and females are significantly protected from cyclophosphamide induced diabetes compared to wild-type controls
• marker analysis confirms that multiple susceptibility loci are entirely NOD derived

hematopoietic system
abnormal T cell physiology ( J:108590 )
• unlike in wild-type controls no dual TCRA expressing cells are present




Genotype
MGI:4944219
ht6
Allelic
Composition		 Tcratm1Mjo/Tcra+
Genetic
Background		 SJL.129P2-Tcratm1Mjo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:108590 )
N
• no difference in the susceptibility to experimental autoimmune encephalomyelitis is detected compared to wild-type controls




Genotype
MGI:6154363
cx7
Allelic
Composition		 Tcratm1Mjo/Tcratm1Mjo
X/Yaa
Genetic
Background		 BXSB.129P2(Cg)-Tcratm1Mjo/Theo
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
Yaa mutation (18 available); any Yaa mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:120153 )
N
• due to the absense of alpha/beta T cells these Yaa-bearing males do not develop hypergammaglobulinemia, anti-chromatin auto-antibodies, enlarged lymph nodes or spleen, hemolytic anemia, immune complex glomerulonephritis, monocytosis, or the lupus-like autoimmune disease that normally causes premature death in Yaa-bearing males on the BXSB background, but instead these males are reported to live beyond 300 days




Genotype
MGI:4947940
cx8
Allelic
Composition		 Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
extended life span ( J:38492 )
• relative to mutant mice wild-type for Tcra

immune system
decreased immunoglobulin level ( J:38492 )
• lower titers of immunoglobulins, other than IgE, compared to mutant mice wild-type for Tcra
decreased autoantibody level ( J:38492 )
• lower titers autoantibodies compared to mutant mice wild-type for Tcra

integument
skin lesions ( J:38492 )
• development of skin lesions is delayed (develop by 7 to 8 months of age) compared to mutant mice wild-type by Tcra

renal/urinary system
abnormal kidney morphology ( J:38492 )
• substantial reduction in renal disease compared to mutant mice wild-type for Tcra

hematopoietic system
decreased immunoglobulin level ( J:38492 )
• lower titers of immunoglobulins, other than IgE, compared to mutant mice wild-type for Tcra




Genotype
MGI:4947943
cx9
Allelic
Composition		 Cd40lgtm1Flv/Y
Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Flv mutation (1 available); any Cd40lg mutation (14 available)
Faslpr mutation (39 available); any Fas mutation (82 available)
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased autoantibody level ( J:38492 )
• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg
• decrease in the anti-snRNP and anti-Ig titers relative to mutant mice compared to mutant mice wild-type for Cd40lg
increased anti-double stranded DNA antibody level ( J:38492 )
• relative to mutant mice wild-type for Tcra

integument
integument phenotype ( J:38492 )
N
• do not develop the skin lesions seen in mutant mice wild-type for Tcra and/or Cd40lg

renal/urinary system
abnormal kidney morphology ( J:38492 )
• renal disease is decreased compared to mutant mice wild-type Cd40lg but more diseased than mutant mice wild-type for Tcra




Genotype
MGI:4947944
cx10
Allelic
Composition		 Cd40lgtm1Flv/Cd40lgtm1Flv
Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lgtm1Flv mutation (1 available); any Cd40lg mutation (14 available)
Faslpr mutation (39 available); any Fas mutation (82 available)
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased autoantibody level ( J:38492 )
• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg
• decrease in the anti-snRNP and anti-Ig titers relative to mutant mice compared to mutant mice wild-type for Cd40lg
increased anti-double stranded DNA antibody level ( J:38492 )
• relative to mutant mice wild-type for Tcra

integument
integument phenotype ( J:38492 )
N
• do not develop the skin lesions seen in mutant mice wild-type for Tcra and/or Cd40lg

renal/urinary system
abnormal kidney morphology ( J:38492 )
• renal disease is decreased compared to mutant mice wild-type Cd40lg but more diseased than mutant mice wild-type for Tcra




Genotype
MGI:4947953
cx11
Allelic
Composition		 Mpztm1Msch/Mpz+
Tcratm1Mjo/Tcratm1Mjo
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mpztm1Msch mutation (0 available); any Mpz mutation (28 available)
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
increased Schwann cell number ( J:59319 )
• increase in the number of Schwann cells around the quadriceps femoral nerves at 13 months of age is less than that in age matched mutant mice heterozygous for the Tcra null allele
abnormal neuron morphology ( J:59319 )
• pathological lesions indicative of compromised myelin maintenance in the quadriceps femoral nerves at 13 months of age are less severe than those in age matched mutant mice heterozygous for the Tcra null allele
abnormal myelin sheath morphology ( J:59319 )
• myelin sheaths of quadriceps femoral nerves at 13 months of age are thicker than those in age matched mutant mice heterozygous for the Tcra null allele
abnormal nervous system physiology ( J:59319 )
• fewer macrophages are found in quadriceps nerves compared to mutant mice heterozygous for the Tcra null allele
abnormal nerve conduction ( J:59319 )
• impaired conduction with prolonged latencies of M-responses and of F waves after distal or proximal stimulations
• impairment tends to be less severe than in mutant mice heterozygous for the Tcra null allele
decreased nerve conduction velocity ( J:59319 )
• reduction is less severe than in mutant mice heterozygous for the Tcra null allele

immune system
decreased T cell number ( J:59319 )
• absence of mature alpha beta lymphocytes

hematopoietic system
decreased T cell number ( J:59319 )
• absence of mature alpha beta lymphocytes




Genotype
MGI:4944220
cx12
Allelic
Composition		 Faslpr/Faslpr
Tcratm1Mjo/Tcratm1Mjo
Genetic
Background		 involves: 129P2/OlaHsd * MRL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:26250 )
N
• unlike in mutant mice wild-type for Tcra, massive lymphadenopathy is not seen at 16 weeks of age
increased T cell number ( J:26250 )
• 6 fold increase in TCRB+ cells compared to mutant mice wild-type for Fas
• within the TCRB+ cell population the proportion of DN B220+ cells is increased compared mutant mice wild-type for Fas
increased gamma-delta T cell number ( J:26250 )
• 15 fold expansion at 16 weeks of age compared to mutant mice wild-type for Fas
• the majority of these cells express B220 and DN as a result of preferential expansion (300 fold) of this population of cells
increased gamma-delta intraepithelial T cell number ( J:26250 )
• increase in the proportion of T cells in the peripheral lymph nodes expressing the gamma delta variable regions typical of intestinal intraepithelial T cell compared to mutant mice wild-type for Fas
kidney inflammation ( J:45448 )
• periglomerular infiltration and perivasculitis

renal/urinary system
increased urine protein level ( J:45448 )
• compared to age-matched B10.A mice
kidney inflammation ( J:45448 )
• periglomerular infiltration and perivasculitis
abnormal kidney morphology ( J:45448 )
• develop glomerular, interstitial and sometimes perivascular lesions
• lesion development is reduced compared mutant mice wild-type for Tcra
abnormal renal glomerulus morphology ( J:45448 )
• focal glomerular hypercellularity

homeostasis/metabolism
increased blood urea nitrogen level ( J:45448 )
• significantly elevated
increased urine protein level ( J:45448 )
• compared to age-matched B10.A mice

hematopoietic system
increased T cell number ( J:26250 )
• 6 fold increase in TCRB+ cells compared to mutant mice wild-type for Fas
• within the TCRB+ cell population the proportion of DN B220+ cells is increased compared mutant mice wild-type for Fas
increased gamma-delta T cell number ( J:26250 )
• 15 fold expansion at 16 weeks of age compared to mutant mice wild-type for Fas
• the majority of these cells express B220 and DN as a result of preferential expansion (300 fold) of this population of cells
increased gamma-delta intraepithelial T cell number ( J:26250 )
• increase in the proportion of T cells in the peripheral lymph nodes expressing the gamma delta variable regions typical of intestinal intraepithelial T cell compared to mutant mice wild-type for Fas




Genotype
MGI:4944218
cx13
Allelic
Composition		 Faslpr/Faslpr
Tcratm1Mjo/Tcra+
Genetic
Background		 MRL.Cg-Tcratm1Mjo Faslpr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faslpr mutation (39 available); any Fas mutation (82 available)
Tcratm1Mjo mutation (7 available); any Tcra mutation (98 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:108590 )
N
• no difference in the susceptibility to systemic lupus erythematosus is detected compared to wild-type controls




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory